EU acute cumulative exposure assessment (2018) Tier I and Tier II

This standard action is of type: Single value risks

This standard action is based on work done in 2018 (van Klaveren et al. (2019a)). In the context of the second framework partnership agreement between the National Institute for Public Health and the Environment of the Netherlands (RIVM) and the European Food Safety Authority (EFSA) acute cumulative dietary exposure assessments were performed for two cumulative assessment groups (CAGs) of pesticides that affect the nervous system: pesticides causing brain and/or erythrocyte AChE inhibition (CAG-NAN, 47 pesticides) and pesticides causing functional alterations of the motor division (CAG-NAM, 100 pesticides). The exposure assessments used monitoring data collected by the Netherlands under their official monitoring programmes in 2014, 2015 and 2016 and individual Dutch food consumption data. Exposure estimates were obtained for each group of pesticides using the MCRA software. The Standing Committee on Plants, Animals, Food and Feed (SC PAFF) discussed the scope of the assessment in 2018 and agreed on the parameters to be used for the cumulative exposure assessment. Based on that discussion, a very conservative tier I modelling approach and a refined, but still conservative tier II modelling approach were used. In these assessments, common risk assessment practice was followed and the cumulative exposure was expressed as the total riskcharacterisation ratio hazard/exposure \(H/E\) at the 50th, 90th, 95th, 99th and 99.9th percentile of the exposure distribution.

Table 380 Datasources for EU acute cumulative exposure assessment (2018) Tier I and Tier II.
Table Group Name Repository Type

AssessmentGroupMemberships

LeanCAGsAssessmentGroupMembership10%p999.xlsx

Standard Actions/EU 2018 Acute Cumulative Exposure Assessment

Fixed

AuthorisedUses

SecondaryInputData.mdb

Standard Actions/EU 2018 Acute Cumulative Exposure Assessment

Fixed

Compounds

SecondaryInputData.mdb

Standard Actions/EU 2018 Acute Cumulative Exposure Assessment

Fixed

Effects

SecondaryInputData.mdb

Standard Actions/EU 2018 Acute Cumulative Exposure Assessment

Fixed

FoodExtrapolations

SecondaryInputData.mdb

Standard Actions/EU 2018 Acute Cumulative Exposure Assessment

Fixed

FoodTranslations

SecondaryInputData.mdb

Standard Actions/EU 2018 Acute Cumulative Exposure Assessment

Fixed

Foods

SecondaryInputData.mdb

Standard Actions/EU 2018 Acute Cumulative Exposure Assessment

Fixed

HazardDoses

SecondaryInputData.mdb

Standard Actions/EU 2018 Acute Cumulative Exposure Assessment

Fixed

MaximumResidueLimits

SecondaryInputData.mdb

Standard Actions/EU 2018 Acute Cumulative Exposure Assessment

Fixed

Processing

SecondaryInputData.mdb

Standard Actions/EU 2018 Acute Cumulative Exposure Assessment

Fixed

ResidueDefinitions

SecondaryInputData.mdb

Standard Actions/EU 2018 Acute Cumulative Exposure Assessment

Fixed

UnitVariability

UnitVar36.mdb

Standard Actions/EU 2018 Acute Cumulative Exposure Assessment

Variable

UnitVariability

UnitVarPrimo.mdb

Standard Actions/EU 2018 Acute Cumulative Exposure Assessment

Variable

Concentrations

a_ConcentrationsSSD_NAM.mdb

Standard Actions/EU 2018 Acute Cumulative Exposure Assessment

Variable

Concentrations

a_ConcentrationsSSD_NAN.mdb

Standard Actions/EU 2018 Acute Cumulative Exposure Assessment

Variable

Survey

a_ConsumptionsNL2.mdb

Standard Actions/EU 2018 Acute Cumulative Exposure Assessment

Fixed

Survey

a_ConsumptionsNL3_6.mdb

Standard Actions/EU 2018 Acute Cumulative Exposure Assessment

Fixed