MCRA Documentation
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User guide

  • Introduction to MCRA
    • User interface
      • Welcome page
      • Registering
      • Logging in
        • Setting up two-factor authentication
        • Authenticator apps
          • Google Authenticator
          • Microsoft Authenticator
          • Windows app: 2Fast Authenticator
        • Request an authenticator QR code
      • Main user interface
    • Data and calculation model
      • Modular design
      • Nominal run and uncertainty analysis
      • Variability diagnostics
      • Retain & Refine and tiered approaches
      • Uncertainty
        • Uncertainty due to limited sampled data
          • Empirical method, resampling
          • Parametric methods
        • Uncertainty due to missing data
        • Uncertainty due to modelling approach
    • Data repository
      • Creating and uploading data files
      • Moving repositories and data sources
      • Repository access levels
      • Linking remote data repositories
    • Workspaces and actions
      • Workspace browser
      • Workspace overview page
      • Action area
        • Scoping: entity selection
          • Implicit versus explicit scoping
          • Comparing new data to set scopes
      • Standard action area
        • Creating a standard action
        • Standard action reports
        • Converting a standard action to a full action
      • Action zip files
    • MCRA web and core
      • MCRA core
      • MCRA web
      • Running MCRA core using the command line interface
    • Results panel
  • Examples
    • Cumulative dietary exposure assessment
      • Introduction
      • Preparation
      • Example 1
      • Example 2
      • Example 3
    • TDS-based exposure and risk assessment
      • Standard actions
    • Aggregate exposure assessment
      • Introduction
      • Preparation
      • Example 1
      • Example 2
    • Hazard characterisations from PoDs
      • Introduction
      • Preparation
      • Example 1
    • Health impact estimates
      • Introduction
      • Preparation
      • Example 1
    • Assessment group membership probabilities
      • Introduction
      • Preparation
      • Example 1
      • Example 2

Reference Manual

  • Modules
    • Primary entity modules
      • Effects
        • Effects from data
        • Effects calculation
        • Effects data formats
        • Effects settings
          • Selection settings
      • Foods
        • Foods from data
        • Foods data formats
        • Food coding systems
          • Food classification: FoodEx1
            • Food code definition
            • Food codes in consumption surveys
            • Food codes in concentration data
            • Food processing
            • Recipes and food translation
            • Market shares and brand loyalty
            • Supertypes
            • Maximum Residue Levels
            • MCRA food code conversion algorithm
          • Food classification: FoodEx2
            • Foods and food hierarchies
            • Facets and facet descriptors
            • Implicit facets
            • Foods as facets
            • The FoodEx 2 coding system
        • FoodEx2
          • Reading and dealing with FoodEx 2 codes
          • Reading and dealing with facets data
            • Reading facets data
            • Dealing with facets
            • Facets in food conversion
            • Using facets that reveal processing data
        • Food hierarchies
          • Reading and dealing with food hierarchy data
          • Reading food hierarchy data
          • Using food hierarchies for food conversion
          • Using hierarchy data in the output
        • Food unit weights
      • Non-dietary exposure sources
        • Non-dietary exposure sources from data
        • Non-dietary exposure sources data formats
      • Populations
        • Populations from data
        • Populations calculation
          • Population definition from dietary surveys
          • Populations data selection
        • Populations data formats
        • Populations settings
          • Selection settings
      • Responses
        • Responses from data
        • Responses data formats
      • Substances
        • Substances from data
        • Substances data formats
        • Substances settings
          • Selection settings
      • Test systems
        • Test systems from data
        • Test systems data formats
    • Consumption modules
      • Consumptions
        • Consumptions from data
        • Consumptions calculation
          • Consumption population definition
          • Multiple surveys
        • Consumptions data formats
        • Consumptions settings
          • Selection settings
          • Calculation settings
          • Output settings
          • Uncertainty settings
        • Consumptions tiers
          • Overview
          • Retrospective dietary CRA (EC 2018) - Acute / Tier I
          • Retrospective dietary CRA (EC 2018) - Chronic / Tier I
          • Retrospective dietary CRA (EC 2018) - Acute / Tier II
          • Retrospective dietary CRA (EC 2018) - Chronic / Tier II
          • Retrospective dietary CRA (EFSA 2022) - Acute / Tier I
          • Retrospective dietary CRA (EFSA 2022) - Chronic / Tier I
          • Retrospective dietary CRA (EFSA 2022) - Acute / Tier II
          • Retrospective dietary CRA (EFSA 2022) - Chronic / Tier II
          • Prospective dietary CRA (EFSA 2023) - Acute / Tier II
          • Prospective dietary CRA (EFSA 2023) - Chronic / Tier II
        • Consumptions uncertainty
      • Food recipes
        • Food recipes from data
        • Food recipes data formats
      • Market shares
        • Market shares from data
        • Market shares data formats
        • Market shares and brand loyalty
      • Single value consumptions
        • Single value consumptions from data
        • Single value consumptions calculation
        • Single value consumptions data formats
        • Single value consumptions settings
          • Calculation settings
    • Occurrence modules
      • Concentration distributions
        • Concentration distributions from data
        • Concentration distributions data formats
      • Concentration limits
        • Concentration limits from data
        • Concentration limits data formats
      • Concentration models
        • Concentration models calculation
          • Concentration model types
            • Empirical model
            • Censored spike lognormal model
            • Censored-Spike Truncated lognormal model
            • Censored Lognormal model
            • Zero-spike censored lognormal model
            • Censored spike MRL model
            • Summary statistics model
          • Concentration models
            • Mixture zero spike and censored lognormal
            • Censored lognormal
            • Mixture censored spike and truncated lognormal
            • Mixture censored spike and lognormal
          • Imputation of non-detect measurements
            • No imputation
            • Impute all censored values by factor times LOQ
            • Impute censored values based on authorized uses
            • No imputation except for authorized uses
          • Deriving the variance of TDS samples from monitoring
        • Concentration models settings
          • Calculation settings
          • Uncertainty settings
        • Concentration models tiers
          • Overview
          • Retrospective dietary CRA (EC 2018) - Acute / Tier I
          • Retrospective dietary CRA (EC 2018) - Chronic / Tier I
          • Retrospective dietary CRA (EC 2018) - Acute / Tier II
          • Retrospective dietary CRA (EC 2018) - Chronic / Tier II
          • Retrospective dietary CRA (EFSA 2012) - Optimistic
          • Retrospective dietary CRA (EFSA 2012) - Acute / Pessimistic
          • Retrospective dietary CRA (EFSA 2012) - Chronic / Pessimistic
          • Retrospective dietary CRA (EFSA 2022) - Acute / Tier I
          • Retrospective dietary CRA (EFSA 2022) - Chronic / Tier I
          • Retrospective dietary CRA (EFSA 2022) - Acute / Tier II
          • Retrospective dietary CRA (EFSA 2022) - Chronic / Tier II
          • Prospective dietary CRA (EFSA 2023) - Acute / Tier II
          • Prospective dietary CRA (EFSA 2023) - Chronic / Tier II
        • Concentration models uncertainty
      • Concentrations
        • Concentrations from data
        • Concentrations calculation
          • Filter samples exceeding the concentration limits
          • Substance conversion
            • Use of substance authorisations in substance conversion
            • Multiple allocations of the same active substance in one sample
          • Food extrapolation
            • 1. Substance-specific imputation of missing values by extrapolated measurements
            • 1. Extrapolation of complete samples for multiple substances
          • Imputation of water concentrations
          • Focal commodity scenario analysis
            • Replace samples with focal commodity samples
            • Append focal commodity samples
            • Replace measurements of focal food/substance combinations
            • Remove measurements of focal food/substance combinations
          • Filter samples by specific sample properties
        • Concentrations data formats
        • Concentrations settings
          • Selection settings
          • Output settings
          • Uncertainty settings
        • Concentrations tiers
          • Overview
          • Retrospective dietary CRA (EC 2018) - Acute / Tier I
          • Retrospective dietary CRA (EC 2018) - Chronic / Tier I
          • Retrospective dietary CRA (EC 2018) - Acute / Tier II
          • Retrospective dietary CRA (EC 2018) - Chronic / Tier II
          • Retrospective dietary CRA (EFSA 2012) - Acute / Pessimistic
          • Retrospective dietary CRA (EFSA 2012) - Chronic / Pessimistic
          • Retrospective dietary CRA (EFSA 2022) - Acute / Tier I
          • Retrospective dietary CRA (EFSA 2022) - Chronic / Tier I
          • Retrospective dietary CRA (EFSA 2022) - Acute / Tier II
          • Retrospective dietary CRA (EFSA 2022) - Chronic / Tier II
          • Prospective dietary CRA (EFSA 2023) - Acute / Tier II
          • Prospective dietary CRA (EFSA 2023) - Chronic / Tier II
        • Concentrations uncertainty
      • Deterministic substance conversion factors
        • Deterministic substance conversion factors from data
        • Deterministic substance conversion factors data formats
      • Focal food concentrations
        • Focal food concentrations from data
        • Focal food concentrations data formats
        • Focal food concentrations settings
          • Selection settings
          • Calculation settings
          • Output settings
      • Food extrapolations
        • Food extrapolations from data
        • Food extrapolations data formats
      • Modelled foods
        • Modelled foods calculation
        • Modelled foods settings
          • Calculation settings
      • Occurrence frequencies
        • Occurrence frequencies from data
        • Occurrence frequencies calculation
        • Occurrence frequencies data formats
        • Occurrence frequencies Settings
          • Selection settings
          • Calculation settings
          • Uncertainty settings
      • Occurrence patterns
        • Occurrence patterns from data
        • Occurrence patterns calculation
        • Occurrence patterns data formats
        • Occurrence patterns settings
          • Selection settings
          • Calculation settings
          • Uncertainty settings
        • Occurrence patterns tiers
          • Overview
          • Retrospective dietary CRA (EC 2018) - Acute / Tier I
          • Retrospective dietary CRA (EC 2018) - Chronic / Tier I
          • Retrospective dietary CRA (EC 2018) - Acute / Tier II
          • Retrospective dietary CRA (EC 2018) - Chronic / Tier II
          • Retrospective dietary CRA (EFSA 2022) - Acute / Tier I
          • Retrospective dietary CRA (EFSA 2022) - Chronic / Tier I
          • Retrospective dietary CRA (EFSA 2022) - Acute / Tier II
          • Retrospective dietary CRA (EFSA 2022) - Chronic / Tier II
          • Prospective dietary CRA (EFSA 2023) - Acute / Tier II
          • Prospective dietary CRA (EFSA 2023) - Chronic / Tier II
      • Processing factors
        • Processing factors from data
        • Processing factors calculation
          • Processing factors fixed or distribution based
            • Nonnegative processing factors
            • Processing factors between 0 and 1
        • Processing factors data formats
        • Processing factors settings
          • Calculation settings
          • Uncertainty settings
        • Processing factors tiers
          • Overview
          • Retrospective dietary CRA (EC 2018) - Acute / Tier I
          • Retrospective dietary CRA (EC 2018) - Chronic / Tier I
          • Retrospective dietary CRA (EC 2018) - Acute / Tier II
          • Retrospective dietary CRA (EC 2018) - Chronic / Tier II
          • Retrospective dietary CRA (EFSA 2012) - Optimistic
          • Retrospective dietary CRA (EFSA 2012) - Acute / Pessimistic
          • Retrospective dietary CRA (EFSA 2012) - Chronic / Pessimistic
          • Retrospective dietary CRA (EFSA 2022) - Acute / Tier I
          • Retrospective dietary CRA (EFSA 2022) - Chronic / Tier I
          • Retrospective dietary CRA (EFSA 2022) - Acute / Tier II
          • Retrospective dietary CRA (EFSA 2022) - Chronic / Tier II
          • Prospective dietary CRA (EFSA 2023) - Acute / Tier II
          • Prospective dietary CRA (EFSA 2023) - Chronic / Tier II
        • Processing factors uncertainty
      • Single value concentrations
        • Single value concentrations from data
        • Single value concentrations calculation
        • Single value concentrations data formats
        • Single value concentrations settings
          • Selection settings
      • Substance authorisations
        • Substance authorisations from data
        • Substance authorisations data formats
      • Substance approvals
        • Substance approvals from data
        • Substance approvals data formats
      • Substance conversions
        • Substance conversions from data
        • Substance conversions data formats
      • Total diet study sample compositions
        • Total diet study sample compositions from data
        • Total diet study sample compositions data formats
      • Unit variability factors
        • Unit variability factors from data
        • Unit variability factors data formats
        • Unit variability factors
          • Calculation settings
        • Unit variability factors tiers
          • Overview
          • Retrospective dietary CRA (EC 2018) - Acute / Tier I
          • Retrospective dietary CRA (EC 2018) - Acute / Tier II
          • Retrospective dietary CRA (EFSA 2012) - Acute / Pessimistic
          • Retrospective dietary CRA (EFSA 2022) - Acute / Tier I
          • Retrospective dietary CRA (EFSA 2022) - Acute / Tier II
          • Prospective dietary CRA (EFSA 2023) - Acute / Tier II
    • Exposure modules
      • Consumptions by modelled food
        • Consumptions by modelled food calculation
        • Consumptions by modelled food settings
          • Calculation settings
          • Output settings
      • Dietary exposures
        • Dietary exposures calculation
          • Acute exposure assessment
            • Modelling unit-to-unit variation
              • Estimation of intake values using the concept of unit variability
              • Beta distribution
              • Lognormal distribution
              • Bernoulli distribution
          • Chronic exposure assessment
            • Chronic exposure models
              • Observed individual means (OIM)
              • Model based and model assisted
              • Betabinomial-Normal model (BBN)
              • Logisticnormal-Normal model (LNN with and without correlation)
              • Discrete/semi-parametric model (ISUF)
                • Model-Then-Add
                • Chronic exposure as a function of covariates
                • Total Diet Study
            • Model-Then-Add
              • The Model step
              • The Add step
            • Chronic exposure as a function of covariates
            • Total Diet Study
              • TDS reduction to limit scenario analysis
          • Substance concentrations generation
            • Sample-based concentrations generation
            • Substance-based concentrations generation
          • Processing correction
          • Chronic exposure assessment, daily consumed foods
            • Model based usual intake
            • Model based usual intake on the transformed scale
            • Model based using a logarithmic transformation
            • Model based using a power transformation
            • Model assisted usual intake on the transformed scale
            • Model assisted using a logarithmic transformation
            • Model assisted using a power transformation
          • Chronic exposure assessment, episodically consumed foods
            • Beta-Binomial model for frequencies (BBN)
            • Model based frequencies for usual intake
            • Model assisted frequencies for usual intake
            • Logistic-Normal model for frequencies (LNN0)
            • Model based frequencies for usual intake
            • Model assisted frequencies for usual intake
            • Logistic-Normal model for frequencies correlated with amounts (LNN)
            • Model based usual intake
            • Model assisted usual intake
        • Dietary exposures settings
          • Selection settings
          • Calculation settings
          • Output settings
          • Uncertainty settings
        • Dietary exposures tiers
          • Overview
          • Retrospective dietary CRA (EC 2018) - Acute / Tier I
          • Retrospective dietary CRA (EC 2018) - Chronic / Tier I
          • Retrospective dietary CRA (EC 2018) - Acute / Tier II
          • Retrospective dietary CRA (EC 2018) - Chronic / Tier II
          • Retrospective dietary CRA (EFSA 2012) - Optimistic
          • Retrospective dietary CRA (EFSA 2012) - Acute / Pessimistic
          • Retrospective dietary CRA (EFSA 2012) - Chronic / Pessimistic
          • Retrospective dietary CRA (EFSA 2022) - Acute / Tier I
          • Retrospective dietary CRA (EFSA 2022) - Chronic / Tier I
          • Retrospective dietary CRA (EFSA 2022) - Acute / Tier II
          • Retrospective dietary CRA (EFSA 2022) - Chronic / Tier II
          • Prospective dietary CRA (EFSA 2023) - Acute / Tier II
          • Prospective dietary CRA (EFSA 2023) - Chronic / Tier II
      • High exposure food substance combinations
        • High exposure food substance combinations calculation
          • Screening calculation for large Cumulative Assessment Groups
            • Statistical model for the screening step (acute exposure)
            • Statistical model for the screening step (chronic exposure)
        • High exposure food substance combinations settings
          • Calculation settings
      • Exposures
        • Exposures calculation
          • Combining dietary and non-dietary exposures
            • Example 1
            • Example 2
            • Example 3
          • Internal exposures calculation
            • Calculation of internal concentrations using absorption factors
            • Calculation of internal concentrations using kinetic models
              • Dosing patterns
              • Non-stationary period
          • Counting of co-exposure
          • Maximum Cumulative Ratio
            • Risk based, standardised or unweighted exposures
        • Exposures settings
          • Calculation settings
          • Output settings
          • Uncertainty settings
      • Exposure mixtures
        • Exposure mixtures calculation
          • Risk based, standardised or unweighted exposures
            • Sparse nonnegative matrix underapproximation
              • Exposure matrix
              • Mechanisms to influence sparsity
            • Substance contributions to components
            • Component exposures in population and subgroups
            • Network analysis
        • Exposure mixtures settings
          • Calculation settings
      • Food conversions
        • Food conversions calculation
          • Substance independent conversion
          • Substance dependent conversion
        • Food conversion settings
          • Calculation settings
        • Food conversions tiers
          • Overview
          • Retrospective dietary CRA (EC 2018) - Acute / Tier I
          • Retrospective dietary CRA (EC 2018) - Chronic / Tier I
          • Retrospective dietary CRA (EC 2018) - Acute / Tier II
          • Retrospective dietary CRA (EC 2018) - Chronic / Tier II
          • Retrospective dietary CRA (EFSA 2012) - Optimistic
          • Retrospective dietary CRA (EFSA 2012) - Chronic / Pessimistic
          • Retrospective dietary CRA (EFSA 2022) - Acute / Tier I
          • Retrospective dietary CRA (EFSA 2022) - Chronic / Tier I
          • Retrospective dietary CRA (EFSA 2022) - Acute / Tier II
          • Retrospective dietary CRA (EFSA 2022) - Chronic / Tier II
          • Prospective dietary CRA (EFSA 2023) - Acute / Tier II
          • Prospective dietary CRA (EFSA 2023) - Chronic / Tier II
      • Biological matrix concentration comparisons
        • Biological matrix concentration comparisons calculation
        • Biological matrix concentration comparisons settings
          • Calculation settings
          • Output settings
      • Exposure biomarker conversions
        • Exposure biomarker conversions from data
          • Uniform distribution
          • Lognormal distribution
          • Beta distribution
        • Exposure biomarker conversions data formats
        • Exposure biomarker conversions
          • Calculation settings
      • Human monitoring analysis
        • Human monitoring analysis calculation
          • Imputation of censored values
          • Imputation of missing values
          • Standardise blood for lipid content
          • Standardise/normalise urine for creatinine or specific gravity
          • Combine urine from different sampling methods
          • Filter for complete cases
          • Apply exposure biomarker conversion of substance concentrations
          • Apply kinetic conversion of substance concentrations from other biological matrices
          • Calculation of acute human monitoring concentrations
          • Calculation of chronic human monitoring concentrations
        • Human monitoring analysis settings
          • Calculation settings
          • Output settings
          • Uncertainty settings
      • Human monitoring data
        • Human monitoring data from data
          • Selection on sampling method
          • Filter on repeated measurements
          • Excluded substances from sampling method
          • Use complete analysed samples
          • Use sampling weights
        • Human monitoring data data formats
          • PARC harmonised HBM data format
        • Human monitoring data settings
          • Selection settings
          • Output settings
          • Uncertainty settings
      • Non-dietary exposures
        • Non-dietary exposures from data
        • Non-dietary exposures data formats
        • Non-dietary exposures settings
          • Calculation settings
          • Uncertainty settings
        • Non-dietary exposures uncertainty
      • Single value dietary exposures
        • Single value dietary exposures calculation
          • Acute single value dietary exposure assessment
            • IESTI (International Estimated Short-Term Intake)
            • Alternative IESTI-styled assessments
            • IESTI special cases
          • Chronic single value dietary exposure assessment
            • TMDI (Theoretical Maximum Dietary Intake)
            • IEDI (International Estimated Dietary Intake)
            • NEDI (National Estimated Dietary Intake): Rees-Day model (I)
            • NEDI (National Estimated Dietary Intake): Rees-Day model (II)
            • Alternative TMDI-, IEDI- or NEDI-styled assessments
        • Single value dietary exposures data formats
        • Single value dietary exposures settings
          • Selection settings
          • Calculation settings
          • Output settings
          • Uncertainty settings
      • Single value non-dietary exposures
        • Single value non-dietary exposures from data
        • Single value non-dietary exposures calculation
          • Acute single value non-dietary exposure assessment
          • Chronic single value non-dietary exposure assessment
        • Single value non-dietary exposures data formats
        • Single value non-dietary exposures settings
          • Selection settings
          • Calculation settings
    • Hazard modules
      • Active substances
        • Active substances from data
        • Active substances calculation
        • Active substances data formats
        • Active substances settings
          • Selection settings
          • Calculation settings
          • Uncertainty settings
      • AOP networks
        • AOP networks from data
        • AOP Networks calculation
        • AOP networks data formats
        • AOP networks settings
          • Selection settings
      • Dose response data
        • Dose response data from data
        • Dose response data data formats
        • Dose response data settings
          • Selection settings
      • Dose response models
        • Dose response models from data
        • Dose response models calculation
          • Proast models
        • Dose response models data formats
        • Dose response models settings
          • Calculation settings
          • Uncertainty settings
      • Effect representations
        • Effect representations from data
        • Effect representations data formats
        • Effect representations
          • Calculation settings
        • Effect representations data formats
      • Hazard characterisations
        • Hazard characterisations from data
        • Hazard characterisations calculation
          • Hazard characterisation type extrapolation
          • Inter-species extrapolation
          • Intra-species extrapolation of hazard characterisations
          • Additional assessment factors
          • In-vitro in-vivo extrapolation (IVIVE)
            • IVIVE for calculating internal hazard characterisations
            • IVIVE for calculating external hazard characterisations
          • Kinetic conversion of hazard characterisations
            • Extrapolation from external to internal hazard characterisations
              • Calculation of internal doses using absorption factors
              • Calculation of internal doses using human PBPK models
              • Calculation of internal doses using animal PBPK models
            • Extrapolation from internal to external hazard characterisations
          • Hazard characterisation imputation
            • Munro P5 (TTC approach)
            • Munro central value
            • Available hazard characterisations distribution P5
            • Available hazard characterisations distribution central value
          • Aggregation over multiple available hazard characterisations
        • Hazard characterisations data formats
        • Hazard characterisations settings
          • Selection settings
          • Calculation settings
          • Uncertainty settings
        • Hazard characterisations tiers
          • Overview
          • Retrospective dietary CRA (EC 2018) - Acute / Tier I
          • Retrospective dietary CRA (EC 2018) - Chronic / Tier I
          • Retrospective dietary CRA (EC 2018) - Acute / Tier II
          • Retrospective dietary CRA (EC 2018) - Chronic / Tier II
          • Retrospective dietary CRA (EFSA 2012) - Optimistic
          • Retrospective dietary CRA (EFSA 2012) - Acute / Pessimistic
          • Retrospective dietary CRA (EFSA 2012) - Chronic / Pessimistic
          • Retrospective dietary CRA (EFSA 2022) - Acute / Tier I
          • Retrospective dietary CRA (EFSA 2022) - Chronic / Tier I
          • Retrospective dietary CRA (EFSA 2022) - Acute / Tier II
          • Retrospective dietary CRA (EFSA 2022) - Chronic / Tier II
          • Prospective dietary CRA (EFSA 2023) - Acute / Tier II
          • Prospective dietary CRA (EFSA 2023) - Chronic / Tier II
      • Inter-species conversions
        • Inter-species conversions from data
        • Inter-species conversions data formats
        • Inter-species conversions settings
          • Selection settings
          • Calculation settings
          • Uncertainty settings
      • Intra species factors
        • Intra species factors from data
        • Intra species factors calculation
        • Intra-species factors data formats
        • Intra species factors settings
          • Selection settings
          • Calculation settings
          • Uncertainty settings
      • Points of departure
        • Points of departure from data
        • Points of departure data formats
        • Points of departure settings
          • Selection settings
          • Uncertainty settings
      • Relative potency factors
        • Relative potency factors from data
        • Relative potency factors calculation
        • Relative potency factors data formats
        • Relative potency factors settings
          • Calculation settings
          • Uncertainty settings
    • In-silico modules
      • Molecular docking models
        • Molecular docking models from data
        • Molecular docking models data formats
        • Molecular docking models
          • Calculation settings
      • QSAR membership models
        • QSAR membership models from data
        • QSAR membership models data formats
        • QSAR membership models
          • Calculation settings
    • Kinetic modules
      • Kinetic models
        • Kinetic models from data
        • Kinetic models data formats
        • Kinetic models settings
          • Calculation settings
          • Uncertainty settings
        • Available kinetic models
          • EuroMix Bisphenols PBPK model (v1)
          • EuroMix Bisphenols PBPK model (v2)
          • EuroMix Generic PBTK model (v5)
          • EuroMix Generic PBTK model (v6)
          • PBK model chlorpyrifos (v1)
          • EuroMix generic PBK model
          • Bisphenol model
    • Risk modules
      • Risks
        • Risks calculation
          • Risk metric calculation type
          • Inverse distribution
          • Risk by food
        • Risks settings
          • Calculation settings
          • Output settings
          • Uncertainty settings
        • Risks tiers
          • Overview
          • Retrospective dietary CRA (EC 2018) - Acute / Tier I
          • Retrospective dietary CRA (EC 2018) - Chronic / Tier I
          • Retrospective dietary CRA (EC 2018) - Acute / Tier II
          • Retrospective dietary CRA (EC 2018) - Chronic / Tier II
          • Retrospective dietary CRA (EFSA 2012) - Optimistic
          • Retrospective dietary CRA (EFSA 2012) - Acute / Pessimistic
          • Retrospective dietary CRA (EFSA 2012) - Chronic / Pessimistic
          • Retrospective dietary CRA (EFSA 2022) - Acute / Tier I
          • Retrospective dietary CRA (EFSA 2022) - Chronic / Tier I
          • Retrospective dietary CRA (EFSA 2022) - Acute / Tier II
          • Retrospective dietary CRA (EFSA 2022) - Chronic / Tier II
          • Prospective dietary CRA (EFSA 2023) - Acute / Tier II
          • Prospective dietary CRA (EFSA 2023) - Chronic / Tier II
      • Single value risks
        • Single value risks calculation
          • Combining single value exposures and hazard characterisations
          • Single value risks from individual risks
            • Adjustment factors and uncertainty specification
            • Background-only adjustment factor
        • Single value risks settings
          • Calculation settings
          • Uncertainty settings
        • Single value risks tiers
          • Overview
          • Retrospective dietary CRA (EC 2018) - Acute / Tier I
          • Retrospective dietary CRA (EC 2018) - Chronic / Tier I
          • Retrospective dietary CRA (EC 2018) - Acute / Tier II
          • Retrospective dietary CRA (EC 2018) - Chronic / Tier II
          • Retrospective dietary CRA (EFSA 2022) - Acute / Tier I
          • Retrospective dietary CRA (EFSA 2022) - Chronic / Tier I
          • Retrospective dietary CRA (EFSA 2022) - Acute / Tier II
          • Retrospective dietary CRA (EFSA 2022) - Chronic / Tier II
          • Prospective dietary CRA (EFSA 2023) - Acute / Tier II
          • Prospective dietary CRA (EFSA 2023) - Chronic / Tier II
  • Standard actions
    • Chronic mixture risk assessment of metals
    • Chronic cumulative exposure assessment PA
    • Chronic cumulative exposure assessment PFAS
    • Demo acute cumulative risk assessment
    • Acute single substance dietary exposure assessment of carbofuran or chlorpyrifos
    • Chronic single substance dietary exposure assessment of lead or atropine
    • Demo Human Monitoring Analysis bisphenols
    • TDS-based long term dietary exposure and risk assessment
    • Long-term dietary exposure and risk of nickel for the Belgian population
    • TDS-based long-term exposure and risk assessment of methylmercury for German children
      • Introduction
      • Standard action options
      • Standard action data
    • Acute Cumulative Risk Assessment Craniofacial Alterations (EFSA 2022)
    • EU acute cumulative exposure assessment (2018) Tier I and Tier II
    • EU chronic cumulative exposure assessment (2018) Tier I and Tier II
    • EU Prospective Dietary Cumulative Risk Assessment (2023)
    • EU Retrospective Dietary Cumulative Risk Assessment (2023)
    • Risk steatosis from imazalil
    • Training prospective risk assessment acute Tier II
    • Training prospective risk assessment chronic Tier II
    • Training substance prioritisation acute neuro
  • Type and Unit definitions
    • Adjustment factor distribution method types
    • Assessment group membership calculation methods
    • Benchmark response type
    • Biological matrix
    • Biological organisation type
    • Biomarker conversion distribution type
    • Body weight unit
    • Boolean type
    • Cluster method type
    • Combination method membership info and PoD presence types
    • Concentration limit value type
    • Concentration model types
    • Concentration unit
    • Concentration value type
    • Consumption intake unit
    • Consumption unit
    • Consumption value type
    • Covariate model types
    • Dietary exposures details level types
    • Dose response model type
    • Dose unit
    • Estimates nature types
    • Exposure approach types
    • Exposure calculation method
    • Exposure method types
    • Exposure path type
    • Exposure route
    • Exposure type
    • Expression type
    • External exposure unit
    • Focal commodity replacement method types
    • Function types
    • Gender type
    • Harvest application type
    • Hazard characterisation type
    • Hazard dose imputation method types
    • Health effect types
    • Individual property type
    • Individual subset types
    • Intake model types
    • Internal model type
    • Isced type
    • Job task type
    • Left-censored data handling methods
    • Mean value correction types
    • Measurement result type
    • Missing value imputation method types
    • Modelled foods calculation source types
    • Month type
    • Multiple substance handling method types
    • Network analysis type
    • Nondetect imputation method types
    • PBK model compartment type
    • PBK model parameter type
    • PBK model species type
    • Point of departure type
    • Point of departure types
    • Probability distribution type
    • Processing distribution type
    • Property level type
    • Response type
    • Risk characterisation ratio
    • Riskmetric calculation types
    • Single value dietary exposures calculation method types
    • Single value risk calculation method types
    • Standardise blood methods
    • Standardise/normalise urine concentration method
    • Substance group selection method types
    • Substance translation allocation method types
    • Target dose selection method types
    • Target doses calculation method types
    • Target level type
    • Test system type
    • Testing method types
    • Time unit
    • Transform types
    • Uncertainty types
    • Unit variability correlation types
    • Unit variability model types
    • Unit variability types
    • Unit weight value type
    • Value qualifier
  • Application Programming Interface (API)
  • Command Line Interface (CLI)
    • Introduction
    • Action template structure
    • Create a new action template
    • Run an action
    • Output files and folder structure
  • Appendices
    • NOAEL collection of Munro et al.
    • Box-Cox power transformation
    • Gauss-Hermite Integration
      • One-dimensional Gauss-Hermite integration
      • Two-dimensional Gauss-Hermite integration
      • Maximum likelihood for the LNN model with two-dimensional Gauss-Hermite integration
  • Glossary

Bibliography

  • Publications using MCRA
  • References
  • Colophon
    • Contributors to MCRA
  • Change Log
    • Version 10.1.0 (2024-08-15)
      • Added
      • Changed
      • Fixed
    • Version 10.0.15 (2024-06-21)
      • Changed
    • Version 10.0.14 (2024-06-18)
      • Fixed
    • Version 10.0.13 (2024-05-28)
      • Added
      • Fixed
    • Version 10.0.12 (2024-05-21)
      • Added
      • Changed
      • Fixed
    • Version 10.0.11 (2024-04-12)
      • Added
      • Changed
      • Fixed
    • Version 10.0.10 (2024-03-07)
      • Changed
      • Added
    • Version 10.0.9 (2024-02-27)
      • Added
      • Changed
      • Fixed
    • Version 10.0.8 (2024-02-12)
      • Changed
    • Version 10.0.7 (2024-02-02)
      • Added
      • Changed
      • Fixed
    • Version 10.0.6 (2024-01-26)
      • Fixed
    • Version 10.0.5 (2023-12-21)
      • Changed
    • Version 10.0.4 (2023-12-18)
      • Added
      • Changed
      • Fixed
    • Version 10.0.3 (2023-12-01)
      • Added
      • Changed
      • Fixed
    • Version 10.0.2 (2023-10-26)
    • Version 10.0.1 (2023-10-23)
      • Added
      • Changed
      • Fixed
    • Version 10.0.0 (2023-06-23)
      • Changed
      • Fixed
    • Version 9.2.10 (2023-06-01)
      • Changed
      • Fixed
    • Version 9.2.9 (2023-05-24)
      • Added
      • Changed
      • Fixed
    • Version 9.2.8 (2023-04-25)
      • Added
      • Fixed
    • Version 9.2.7 (2023-04-03)
      • Added
      • Changed
      • Fixed
    • Version 9.2.6 (2023-03-10)
      • Added
      • Changed
      • Fixed
    • Version 9.2.5 (2023-02-10)
      • Added
      • Changed
      • Fixed
    • Version 9.2.4 (2023-02-03)
      • Added
      • Changed
      • Fixed
    • Version 9.2.3 (2023-01-16)
      • Added
      • Changed
      • Fixed
    • Version 9.2.2 (2022-12-20)
      • Added
      • Changed
      • Fixed
MCRA Documentation
  • MCRA documentation

MCRA documentation

Reference and user manual for MCRA 10 (version 10.1.0).

User guide

  • Introduction to MCRA
  • Examples

Reference Manual

  • Modules
  • Standard actions
  • Type and Unit definitions
  • Application Programming Interface (API)
  • Command Line Interface (CLI)
  • Appendices
  • Glossary

Bibliography

  • Publications using MCRA
  • References
  • Colophon
  • Change Log

MCRA 10.1.0 Documentation history