Points of departure data formats

Points of departure, such as NOAELS and BMDs, describe the critical/reference levels of substance dose in relation to the presence or absence of an effect. If available, the uncertainty of externally specified points of departure can be specified with uncertainty sets (empirical distributions representing possible values) in the points of departure uncertainty table.

Download empty dataset template: Zipped CSV Excel

Points of departure

Nominal points of departure should be presented in this table. Each point of departure should be linked to an effect using the effect code (idEffect) and to substances using the substance code (idSubstance).

Accepted table names: PointsOfDeparture, PointOfDeparture, HazardDoses, HazardDose.

Table 304 Table definition for Points of departure.
Name Type Description Aliases Required

idModel

AlphaNumeric (50)

The dose response model code.

idDoseResponseModel, idModel, idPod, idPointOfDeparture

No

idEffect

AlphaNumeric (50)

The effect code.

idEffect, EffectId, Effect

Yes

idSubstance

AlphaNumeric (50)

The code of the substance.

idSubstance, SubstanceId, SubstanceCode, Substance

Yes

Species

AlphaNumeric (50)

The species used to obtain this point of departure.

Species, System

No

Value

Numeric

Point of departure, can be of various types, e.g. NOAEL, LOAEL, BMD, CED

PointOfDeparture, LimitDose, HazardDose, Value, CED

Yes

Type

PointOfDepartureType

The type of the point of departure, e.g. NOAEL, LOAEL, BMD.

Type, PODType, HazardDoseType, LimitDoseType

No

DoseUnit

DoseUnit

The dose unit (if not specified, then mg/kg is assumed).

DoseUnit, Unit, UnitDose

No

BenchmarkResponse

AlphaNumeric (100)

The benchmark response or effect size.

BenchmarkResponse, CriticalEffectSize, HazardEffectSize

No

ExposureRoute

ExposureRoute

The route of dose administration used in the study to obtain this point of departure. If not specified exposure route = Dietary is assumed.

ExposureRoute, RouteExposure

No

IsCriticalEffect

Boolean

Specifies whether this value is the value associated with the critical effect. If omitted, No is assumed.

IsCriticalEffect

No

TargetLevel

TargetLevelType

The target level, i.e., internal or external. If omitted, external is assumed.

TargetLevel

No

Matrix

BiologicalMatrix

The biological matrix or organ (should be specified when target level is internal).

Matrix, BiologicalMatrix

No

Expression type

ExpressionType

The expression type for (internal) hazard characterisations of which the concentrations are not directly specified at the level of the biological matrix. For instance, urinary expressions expressed in terms of the amount excreted per gram of creatinine or blood concentration expressed per gram of lipids.

ExpressionType

No

PublicationTitle

AlphaNumeric (250)

Title of the publication of the study in which this hazard characterisation was established.

PublicationTitle, Title

No

PublicationAuthors

AlphaNumeric

Author(s) of the publication of the study in which this hazard characterisation was established.

PublicationAuthors, PublicationAuthor, Author, Authors

No

PublicationYear

Integer

Year of the publication of the study in which this hazard characterisation was established.

PublicationYear, Year

No

PublicationUri

AlphaNumeric

Uniform resource identifier of the reference publication.

URI, URL, PublicationURI, PublicationURL

No

Points of departure uncertainty

Often, the PODs found for a substance/effect combination are uncertain. This table facilitates in specifying the POD uncertainty in the form of a set of uncertainty values that may additionally be specified for a substance/effect combination.

Accepted table names: PointsOfDepartureUncertain, PointOfDepartureUncertain, HazardDosesUncertain, HazardDoseUncertain.

Table 305 Table definition for Points of departure uncertainty.
Name Type Description Aliases Required

idDoseResponseModel

AlphaNumeric (50)

The dose response model code (must correspond to values in id column of DoseResponseModels table).

idDoseResponseModel

Yes

idUncertaintySet

AlphaNumeric (50)

The identification code of the uncertainty set. During an uncertainty iteration one set will be picked to be the POD value.

idUncertaintySet, UncertaintyId

Yes

idEffect

AlphaNumeric (50)

The effect code.

idEffect, EffectId, Effect

Yes

idSubstance

AlphaNumeric (50)

The code of the substance.

idSubstance, SubstanceId, SubstanceCode, Substance

Yes

Point of departure

Numeric

Point of departure, can be of various types, e.g. NOAEL, LOAEL, BMD, CED

PointOfDeparture, HazardDose, LimitDose, CED

Yes

DoseResponseModelParameterValues

AlphaNumeric (200)

A comma separated list of the values of the parameters of the model, format: a=1.2,b=3.4,c=5.6

DoseResponseModelParameterValues, ParameterValues

No