Human monitoring analysis
Human monitoring concentrations are substance concentration estimates for a biological matrix (e.g., urine or blood) derived from data obtained from human monitoring studies.
This module has as primary entities: Populations Substances
Output of this module is used by: Exposure mixtures Biological matrix concentration comparisons Risks
Calculation of human monitoring analysis
Human monitoring concentration estimates are computed from data collected in human monitoring studies. These concentration estimates are computed per substance for a selected (human) biological matrix. Modelling includes imputation of missing values and non-detects, as well as correction of concentrations for, e.g., specific gravity. Occasionally, the number of substances measured in the biological matrix of interest is limited or too low to perform a risk assessment or mixture analysis. In such cases, matrix conversion can be applied: substance concentrations measured in other biological matrices are translated to the matrix of interest using a kinetic conversion factor. Cumulative risks of multiple substances are calculated either by using RPFs weighted exposure or by using the sum of risk ratios method using hazard characterisations.
Inputs used: Human monitoring data Active substances Relative potency factors Kinetic models Exposure biomarker conversions
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