Dose response models settings

Calculation settings

Table 270 Calculation settings for module Dose response models.

Name	Type	Description
Index substance	AlphaNumeric	The substance of interest or index substance.
Multiple substances analysis	Boolean	Specifies whether the assessment involves multiple substances.
Calculate a parametric benchmark dose confidence interval	Boolean	A parametric benchmark dose confidence interval (90%) is calculated by the profile likelihood method. If unchecked, the confidence interval is based on a bootstrap sample with uncertainty bounds p5 and p95.

Uncertainty settings

Table 271 Uncertainty settings for module Dose response models.

Name	Type	Description
Perform uncertainty analysis	Boolean	In probabilistic risk assessment of dietary exposure, distributions describe the variability in consumption within a given population of individuals and the variability of the occurrence and level of substances in the consumed foods. However, these calculations do not consider the amount of uncertainty that is due to the limited size of the underlying datasets.
Resample hazard characterisations or RPFs	Boolean	Specifies whether to resample the hazard characterisations or relative potency factors. Requires hazard characterisation or RPF uncertainty to be quantified in DoseResponseModelsUncertain or RelativePotencyFactorsUncertain tables.
Iterations uncertainty analysis	Numeric	Specifies the number of uncertainty cycles (default 100).