Hazard characterisations settings

Selection settings

Table 279 Selection settings for module Hazard characterisations.

Name	Type	Description
Exposure type	ExposureType	The type of exposure considered in the assessment; acute (short term) or chronic (long-term).
Multiple effects analysis	Boolean	Specifies whether the analysis should consider multiple effects. Otherwise, a single focal effect should be selected.
Target level	TargetLevelType	Select to express hazard characterisations at external or internal exposure level. For an aggregate assessment, that is dietary and nondietary exposure data are combined, the target dose level is always internal. When only dietary exposures are available, the target dose level is optional, i.c. external or internal.
Consider critical effect	Boolean	Specifies whether the analysis should look at critical effects such as specified in the Hazard characterisation data source.
Restrict active substances to substances with available hazard characterisations	Boolean	Restrict assessment group membership based on presence/absence of hazard characterisations.
Include related effects of AOP network	Boolean	Include all related key events of the AOP network.

Calculation settings

Table 280 Calculation settings for module Hazard characterisations.

Name	Type	Description
Selected tier	SettingsTemplateType	Specifies all module settings should be set according to a pre-defined tier or using custom settings.
Seed for pseudo-random number generator	Numeric	A value of 0 will use a pseudo-random seed in each run, a value > 0 will provide the same results in a repeated run.
Index substance	AlphaNumeric	The substance of interest or index substance.
Multiple substances analysis	Boolean	Specifies whether the assessment involves multiple substances.
Method	TargetDosesCalculationMethod	Choose method for computing the hazard characterisations: from in-vivo or in-vitro points of departure or both.
Expression type	PointOfDeparture	Specifies how hazard characterisations are expressed: as BMD, as NOAEL, or the expression type is ignored.
Selection method in case of multiple candidate hazard characterisations	TargetDoseSelectionMethod	Choose either the most toxic (default) or an aggregated hazard characterisation when in nominal runs there are multiple available candidates. In uncertainty runs, multiple candidates are resampled.
Impute missing hazard characterisations	Boolean	If checked, missing hazard characterisations are imputed based on Munro NOELs or on other available points of departure.
Imputation method	HazardDoseImputationMethodType	Imputation of Hazard characterisations: use low percentile (P5) or unbiased central estimate from either the Munro set or the available POD collection.
Use BMDs from dose response models	Boolean	If checked, preferably BMDs from dose response models will be used. If these data are not available, other POD data are used.
Use lower limit of BMD	Boolean	If checked, the lower limit of the benchmark dose is used. For an uncertainty run, the lower limit is the p5 of the bootstrap sample, otherwise it is a parametric estimate based on the parameters of the dose response curve.
Use inter-species conversions	Boolean	Use inter-species conversion factors (default value, e.g. 10, or data).
Use intra-species factors	Boolean	Use intra-species conversion factors (default value, e.g. 10, or data).
Additional assessment factor	Numeric	Additional assessment factor for extrapolation of PODs to (human) hazard characterisations.
Use additional assessment factor	Boolean	Use additional assessment factor for extrapolation of PODs to (human) hazard characterisations.
Include dietary and non-dietary routes of exposure	Boolean	Specifies whether the assessment involves both dietary and non-dietary (oral, inhalatory or dermal) routes of exposure.
Convert to single target	Boolean	Convert all substance hazard characterisations from other biological matrices to the same target biological matrix. This conversion is applied when the number of substances measured on the target biological matrix is limited. Substances measured on other matrices can be converted using kinetic conversion models.
Biological matrix	BiologicalMatrix	The target biological matrix (internal compartment) for which exposures are computed.
Use hazard characterisations subgroup	Boolean	Hazard characterisations are dependent on subgroups (e.g. based on age or gender, see dataformats HCSubgroups).

Uncertainty settings

Table 281 Uncertainty settings for module Hazard characterisations.

Name	Type	Description
Resample intra-species factor	Boolean	Specifies whether intra-species factors are resampled from a parametric uncertainty distribution.
Resample hazard characterisations or RPFs	Boolean	Specifies whether to resample the hazard characterisations or relative potency factors. Requires hazard characterisation or RPF uncertainty to be quantified in DoseResponseModelsUncertain or RelativePotencyFactorsUncertain tables.
Lower uncertainty limit (%)	Numeric	Percentage lower bound, e.g. 2.5%.
Upper uncertainty limit (%)	Numeric	Percentage upper bound, e.g. 97.5%.