Kinetic models settings

Calculation settings

Table 323 Calculation settings for module Kinetic models.
Name Type Description
Multiple substances analysis

Boolean

Specifies whether the assessment involves multiple substances.
Include dietary and non-dietary routes of exposure

Boolean

Specifies whether the assessment involves both dietary and non-dietary (oral, inhalatory or dermal) routes of exposure.
Restrict active substances to substances with available hazard characterisations

Boolean

Restrict assessment group membership based on presence/absence of hazard characterisations.
Default oral absorption factor for non-dietary exposure

Numeric

When there is no kinetic model and absorption factors are not specified in file, non-dietary oral exposures (external doses) are multiplied by this factor to determine the absorbed (internal) dose.
Default oral absorption factor for dietary exposure

Numeric

When there is no kinetic model and absorption factors are not specified in file, dietary exposures (external doses) are multiplied by this factor to determine the absorbed (internal) dose .
Default dermal absorption factor for non-dietary exposure

Numeric

When there is no kinetic model and absorption factors are not specified in file, dermal exposures (external doses) are multiplied by this factor to determine the absorbed (internal) dose.
Default inhalation absorption factor for non-dietary exposure

Numeric

When there is no kinetic model and absorption factors are not specified in file, inhalation exposures (external doses) are multiplied by this factor to determine the absorbed (internal) dose.
Number of days

Numeric

The number of days.
Number of events per day for the ORAL dietary dose

Numeric

The daily dose is administered in equal portions (dose / number of events) per event.
Number of initial days skipped

Numeric

This period is skipped in the calculation of the mean internal exposure.
Kinetic model

AlphaNumeric

Code Kinetic Model.
Use parameter variability

Boolean

When specified, use parameter variability.
Specify the type of kinetic model
InternalModelType Specify the type of model to convert external exposure to the internal level.
Number of events per day for the DERMAL nondietary dose

Numeric

The daily dose is administered in equal portions (dose / number of events) per event.
Number of events per day for the INHALATION nondietary dose

Numeric

The daily dose is administered in equal portions (dose / number of events) per event.
Number of events per day for the ORAL nondietary dose

Numeric

The daily dose is administered in equal portions (dose / number of events) per event.
Specify the hours (events).

Numeric

Specify the hours (events) on which a dose is applied. Allowed numbers are 1, 2, 3, 4,…, 24 separated by spaces.
Specify events

Boolean

if checked, a sequence of hours can be specified, otherswise the events are derived based on the number of doses per day.
Use kinetic conversion factors subgroup

Boolean

Kinetic conversion factors are dependent on subgroups (e.g. based on age or gender, see dataformats KineticConversionfactorsSgs).

Uncertainty settings

Table 324 Uncertainty settings for module Kinetic models.
Name Type Description
Resample kinetic model parameter values

Boolean

Specifies whether kinetic model parameter values are resampled.