Concentration models tiers
In addition to the possibility for users to work with their own choices for all settings, MCRA implements four tiers from two documents:
The optimistic and pessimistic basic assessments from the EFSA 2012 Guidance on the Use of Probabilistic Methodology for Modelling Dietary Exposure to Pesticide Residues (EFSA (2012)).
Tier 1 and 2 from the European Commission working document SANTE-2015-10216 rev. 7 (2018) on risk management aspects related to the assessment of cumulative exposure (EC (2018)).
Overview
| Name | EC 2018 Acute Tier I | EC 2018 Chronic - Tier I | EC 2018 Acute Tier II | EC 2018 Chronic Tier II | EFSA 2012 Optimistic | EFSA 2012 Acute Pessimistic | EFSA 2012 Chronic Pessimistic | EFSA 2022 Acute Tier I | EFSA 2022 Chronic Tier I | EFSA 2022 Acute Tier II | EFSA 2022 Chronic Tier II | EFSA 2023 Acute Prospective Tier II | EFSA 2023 Chronic Prospective Tier II |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Default concentration model |
Empirical |
Empirical |
Empirical |
Empirical |
Empirical |
NonDetectSpikeLogNormal |
NonDetectSpikeLogNormal |
Empirical |
Empirical |
Empirical |
Empirical |
Empirical |
Empirical |
Include MRL fallback model |
false |
false |
false |
false |
false |
true |
true |
false |
false |
false |
false |
false |
false |
Restrict LOR imputation to authorised uses |
false |
false |
false |
false |
false |
false |
false |
false |
false |
false |
false |
false |
|
Censored values replacement |
ReplaceByLOR |
ReplaceByLOR |
ReplaceByLOR |
ReplaceByLOR |
ReplaceByZero |
ReplaceByLOR |
ReplaceByLOR |
ReplaceByLOR |
ReplaceByLOR |
ReplaceByLOR |
ReplaceByLOR |
ReplaceByLOR |
ReplaceByLOR |
Factor f (f x LOR or f x LOD or LOD + f x (LOQ - LOD) |
0.5 |
0.5 |
0.5 |
0.5 |
1 |
1 |
0.5 |
0.5 |
0.5 |
0.5 |
0.5 |
0.5 |
|
Sample based |
true |
true |
true |
true |
true |
true |
true |
true |
true |
true |
true |
true |
true |
Impute missing values from available values (if unchecked, missing values are imputed with 0) |
true |
true |
true |
true |
false |
true |
true |
true |
true |
true |
true |
true |
true |
Correlate imputed values with sample potency |
true |
true |
false |
false |
false |
true |
true |
true |
true |
false |
false |
false |
false |
Use occurrence frequencies for imputation |
true |
true |
true |
true |
false |
true |
true |
true |
true |
true |
true |
||
Parametric uncertainty |
false |
false |
false |
false |
false |
true |
false |
false |
false |
false |
false |
false |
false |
Filter samples exceeding the concentration limits |
false |
false |
false |
false |
false |
false |
false |
false |
false |
false |
true |
true |
|
Use substance conversion rules |
true |
true |
true |
true |
true |
true |
true |
true |
true |
true |
|||
Substance conversion method |
UseMostToxic |
UseMostToxic |
DrawRandom |
DrawRandom |
UseMostToxic |
UseMostToxic |
DrawRandom |
DrawRandom |
DrawRandom |
DrawRandom |
|||
Retain all allocated substances after active substance allocation |
true |
true |
true |
true |
true |
true |
true |
true |
true |
true |
|||
Account for substance authorisations in substance conversions |
false |
false |
true |
true |
false |
false |
true |
true |
true |
true |
|||
Fix duplicate substance allocation inconsistencies |
false |
false |
false |
false |
false |
false |
false |
false |
false |
false |
|||
Use extrapolation rules |
true |
true |
true |
true |
false |
false |
false |
false |
false |
false |
|||
Threshold for extrapolation |
10 |
10 |
10 |
10 |
|||||||||
Restrict extrapolations to equal MRLs |
true |
true |
true |
true |
|||||||||
Restrict extrapolations to authorised uses |
true |
true |
true |
true |
|||||||||
Impute water concentrations |
true |
true |
true |
true |
true |
true |
true |
true |
true |
true |
|||
Water concentration value (µg/kg) |
0.1 |
0.1 |
0.05 |
0.05 |
0.1 |
0.1 |
0.05 |
0.05 |
0.05 |
0.05 |
|||
Restrict water imputation to the five most toxic substances |
true |
true |
true |
true |
true |
true |
true |
true |
true |
true |
|||
Restrict water imputation to authorised uses |
false |
false |
false |
false |
false |
false |
false |
false |
false |
false |
|||
Restrict water imputation to approved substances |
false |
false |
false |
false |
true |
true |
true |
true |
true |
true |
|||
Apply occurrence pattern percentages |
false |
false |
true |
true |
false |
false |
true |
true |
true |
true |
|||
Target level |
External |
External |
External |
External |
External |
External |
External |
External |
External |
External |
External |
External |
External |
Scale up use frequency to 100% |
true |
true |
true |
true |
true |
true |
|||||||
Restrict use percentage up-scaling to authorised uses |
true |
true |
true |
true |
true |
true |
|||||||
MRL Factor (f x MRL) |
1 |
1 |
|||||||||||
Concentration limit filter exceedance factor |
2 |
2 |
|||||||||||
Include focal commodity concentrations |
true |
true |
|||||||||||
Focal commodity substance occurrence percentage |
20 |
20 |
|||||||||||
Adjustment factor for the focal food/substance concentration |
1 |
1 |
|||||||||||
Use deterministic substance conversions for focal commodity |
true |
true |
The sections below describe the settings specified by each tier in detail.
Retrospective dietary CRA (EC 2018) - Acute / Tier I
| Name | Setting | From input tier | In module |
|---|---|---|---|
| Default concentration model | Empirical | ||
| Include MRL fallback model | false | ||
| Restrict LOR imputation to authorised uses | false | ||
| Censored values replacement | ReplaceByLOR | ||
| Factor f (f x LOR or f x LOD or LOD + f x (LOQ - LOD) | 0.5 | ||
| Sample based | true | ||
| Impute missing values from available values (if unchecked, missing values are imputed with 0) | true | ||
| Correlate imputed values with sample potency | true | ||
| Use occurrence frequencies for imputation | true | ||
| Parametric uncertainty | false | ||
| Filter samples exceeding the concentration limits | false | Retrospective dietary CRA (EC 2018) - Acute / Tier I | Concentrations |
| Use substance conversion rules | true | Retrospective dietary CRA (EC 2018) - Acute / Tier I | Concentrations |
| Substance conversion method | UseMostToxic | Retrospective dietary CRA (EC 2018) - Acute / Tier I | Concentrations |
| Retain all allocated substances after active substance allocation | true | Retrospective dietary CRA (EC 2018) - Acute / Tier I | Concentrations |
| Account for substance authorisations in substance conversions | false | Retrospective dietary CRA (EC 2018) - Acute / Tier I | Concentrations |
| Fix duplicate substance allocation inconsistencies | false | Retrospective dietary CRA (EC 2018) - Acute / Tier I | Concentrations |
| Use extrapolation rules | true | Retrospective dietary CRA (EC 2018) - Acute / Tier I | Concentrations |
| Threshold for extrapolation | 10 | Retrospective dietary CRA (EC 2018) - Acute / Tier I | Concentrations |
| Restrict extrapolations to equal MRLs | true | Retrospective dietary CRA (EC 2018) - Acute / Tier I | Concentrations |
| Restrict extrapolations to authorised uses | true | Retrospective dietary CRA (EC 2018) - Acute / Tier I | Concentrations |
| Impute water concentrations | true | Retrospective dietary CRA (EC 2018) - Acute / Tier I | Concentrations |
| Water concentration value (µg/kg) | 0.1 | Retrospective dietary CRA (EC 2018) - Acute / Tier I | Concentrations |
| Restrict water imputation to the five most toxic substances | true | Retrospective dietary CRA (EC 2018) - Acute / Tier I | Concentrations |
| Restrict water imputation to authorised uses | false | Retrospective dietary CRA (EC 2018) - Acute / Tier I | Concentrations |
| Restrict water imputation to approved substances | false | Retrospective dietary CRA (EC 2018) - Acute / Tier I | Concentrations |
| Apply occurrence pattern percentages | false | Retrospective dietary CRA (EC 2018) - Acute / Tier I | Occurrence patterns |
| Target level | External | Retrospective dietary CRA (EC 2018) - Acute / Tier I | Hazard characterisations |
Retrospective dietary CRA (EC 2018) - Chronic / Tier I
| Name | Setting | From input tier | In module |
|---|---|---|---|
| Default concentration model | Empirical | ||
| Include MRL fallback model | false | ||
| Restrict LOR imputation to authorised uses | false | ||
| Censored values replacement | ReplaceByLOR | ||
| Factor f (f x LOR or f x LOD or LOD + f x (LOQ - LOD) | 0.5 | ||
| Sample based | true | ||
| Impute missing values from available values (if unchecked, missing values are imputed with 0) | true | ||
| Correlate imputed values with sample potency | true | ||
| Use occurrence frequencies for imputation | true | ||
| Parametric uncertainty | false | ||
| Filter samples exceeding the concentration limits | false | Retrospective dietary CRA (EC 2018) - Chronic / Tier I | Concentrations |
| Use substance conversion rules | true | Retrospective dietary CRA (EC 2018) - Chronic / Tier I | Concentrations |
| Substance conversion method | UseMostToxic | Retrospective dietary CRA (EC 2018) - Chronic / Tier I | Concentrations |
| Retain all allocated substances after active substance allocation | true | Retrospective dietary CRA (EC 2018) - Chronic / Tier I | Concentrations |
| Account for substance authorisations in substance conversions | false | Retrospective dietary CRA (EC 2018) - Chronic / Tier I | Concentrations |
| Fix duplicate substance allocation inconsistencies | false | Retrospective dietary CRA (EC 2018) - Chronic / Tier I | Concentrations |
| Use extrapolation rules | true | Retrospective dietary CRA (EC 2018) - Chronic / Tier I | Concentrations |
| Threshold for extrapolation | 10 | Retrospective dietary CRA (EC 2018) - Chronic / Tier I | Concentrations |
| Restrict extrapolations to equal MRLs | true | Retrospective dietary CRA (EC 2018) - Chronic / Tier I | Concentrations |
| Restrict extrapolations to authorised uses | true | Retrospective dietary CRA (EC 2018) - Chronic / Tier I | Concentrations |
| Impute water concentrations | true | Retrospective dietary CRA (EC 2018) - Chronic / Tier I | Concentrations |
| Water concentration value (µg/kg) | 0.1 | Retrospective dietary CRA (EC 2018) - Chronic / Tier I | Concentrations |
| Restrict water imputation to the five most toxic substances | true | Retrospective dietary CRA (EC 2018) - Chronic / Tier I | Concentrations |
| Restrict water imputation to authorised uses | false | Retrospective dietary CRA (EC 2018) - Chronic / Tier I | Concentrations |
| Restrict water imputation to approved substances | false | Retrospective dietary CRA (EC 2018) - Chronic / Tier I | Concentrations |
| Apply occurrence pattern percentages | false | Retrospective dietary CRA (EC 2018) - Chronic / Tier I | Occurrence patterns |
| Target level | External | Retrospective dietary CRA (EC 2018) - Chronic / Tier I | Hazard characterisations |
Retrospective dietary CRA (EC 2018) - Acute / Tier II
| Name | Setting | From input tier | In module |
|---|---|---|---|
| Default concentration model | Empirical | ||
| Include MRL fallback model | false | ||
| Restrict LOR imputation to authorised uses | false | ||
| Censored values replacement | ReplaceByLOR | ||
| Factor f (f x LOR or f x LOD or LOD + f x (LOQ - LOD) | 0.5 | ||
| Sample based | true | ||
| Impute missing values from available values (if unchecked, missing values are imputed with 0) | true | ||
| Correlate imputed values with sample potency | false | ||
| Use occurrence frequencies for imputation | true | ||
| Parametric uncertainty | false | ||
| Filter samples exceeding the concentration limits | false | Retrospective dietary CRA (EC 2018) - Acute / Tier II | Concentrations |
| Use substance conversion rules | true | Retrospective dietary CRA (EC 2018) - Acute / Tier II | Concentrations |
| Substance conversion method | DrawRandom | Retrospective dietary CRA (EC 2018) - Acute / Tier II | Concentrations |
| Retain all allocated substances after active substance allocation | true | Retrospective dietary CRA (EC 2018) - Acute / Tier II | Concentrations |
| Account for substance authorisations in substance conversions | true | Retrospective dietary CRA (EC 2018) - Acute / Tier II | Concentrations |
| Fix duplicate substance allocation inconsistencies | false | Retrospective dietary CRA (EC 2018) - Acute / Tier II | Concentrations |
| Use extrapolation rules | true | Retrospective dietary CRA (EC 2018) - Acute / Tier II | Concentrations |
| Threshold for extrapolation | 10 | Retrospective dietary CRA (EC 2018) - Acute / Tier II | Concentrations |
| Restrict extrapolations to equal MRLs | true | Retrospective dietary CRA (EC 2018) - Acute / Tier II | Concentrations |
| Restrict extrapolations to authorised uses | true | Retrospective dietary CRA (EC 2018) - Acute / Tier II | Concentrations |
| Impute water concentrations | true | Retrospective dietary CRA (EC 2018) - Acute / Tier II | Concentrations |
| Water concentration value (µg/kg) | 0.05 | Retrospective dietary CRA (EC 2018) - Acute / Tier II | Concentrations |
| Restrict water imputation to the five most toxic substances | true | Retrospective dietary CRA (EC 2018) - Acute / Tier II | Concentrations |
| Restrict water imputation to authorised uses | false | Retrospective dietary CRA (EC 2018) - Acute / Tier II | Concentrations |
| Restrict water imputation to approved substances | false | Retrospective dietary CRA (EC 2018) - Acute / Tier II | Concentrations |
| Apply occurrence pattern percentages | true | Retrospective dietary CRA (EC 2018) - Acute / Tier II | Occurrence patterns |
| Scale up use frequency to 100% | true | Retrospective dietary CRA (EC 2018) - Acute / Tier II | Occurrence patterns |
| Restrict use percentage up-scaling to authorised uses | true | Retrospective dietary CRA (EC 2018) - Acute / Tier II | Occurrence patterns |
| Target level | External | Retrospective dietary CRA (EC 2018) - Acute / Tier II | Hazard characterisations |
Retrospective dietary CRA (EC 2018) - Chronic / Tier II
| Name | Setting | From input tier | In module |
|---|---|---|---|
| Default concentration model | Empirical | ||
| Include MRL fallback model | false | ||
| Restrict LOR imputation to authorised uses | false | ||
| Censored values replacement | ReplaceByLOR | ||
| Factor f (f x LOR or f x LOD or LOD + f x (LOQ - LOD) | 0.5 | ||
| Sample based | true | ||
| Impute missing values from available values (if unchecked, missing values are imputed with 0) | true | ||
| Correlate imputed values with sample potency | false | ||
| Use occurrence frequencies for imputation | true | ||
| Parametric uncertainty | false | ||
| Filter samples exceeding the concentration limits | false | Retrospective dietary CRA (EC 2018) - Chronic / Tier II | Concentrations |
| Use substance conversion rules | true | Retrospective dietary CRA (EC 2018) - Chronic / Tier II | Concentrations |
| Substance conversion method | DrawRandom | Retrospective dietary CRA (EC 2018) - Chronic / Tier II | Concentrations |
| Retain all allocated substances after active substance allocation | true | Retrospective dietary CRA (EC 2018) - Chronic / Tier II | Concentrations |
| Account for substance authorisations in substance conversions | true | Retrospective dietary CRA (EC 2018) - Chronic / Tier II | Concentrations |
| Fix duplicate substance allocation inconsistencies | false | Retrospective dietary CRA (EC 2018) - Chronic / Tier II | Concentrations |
| Use extrapolation rules | true | Retrospective dietary CRA (EC 2018) - Chronic / Tier II | Concentrations |
| Threshold for extrapolation | 10 | Retrospective dietary CRA (EC 2018) - Chronic / Tier II | Concentrations |
| Restrict extrapolations to equal MRLs | true | Retrospective dietary CRA (EC 2018) - Chronic / Tier II | Concentrations |
| Restrict extrapolations to authorised uses | true | Retrospective dietary CRA (EC 2018) - Chronic / Tier II | Concentrations |
| Impute water concentrations | true | Retrospective dietary CRA (EC 2018) - Chronic / Tier II | Concentrations |
| Water concentration value (µg/kg) | 0.05 | Retrospective dietary CRA (EC 2018) - Chronic / Tier II | Concentrations |
| Restrict water imputation to the five most toxic substances | true | Retrospective dietary CRA (EC 2018) - Chronic / Tier II | Concentrations |
| Restrict water imputation to authorised uses | false | Retrospective dietary CRA (EC 2018) - Chronic / Tier II | Concentrations |
| Restrict water imputation to approved substances | false | Retrospective dietary CRA (EC 2018) - Chronic / Tier II | Concentrations |
| Apply occurrence pattern percentages | true | Retrospective dietary CRA (EC 2018) - Chronic / Tier II | Occurrence patterns |
| Scale up use frequency to 100% | true | Retrospective dietary CRA (EC 2018) - Chronic / Tier II | Occurrence patterns |
| Restrict use percentage up-scaling to authorised uses | true | Retrospective dietary CRA (EC 2018) - Chronic / Tier II | Occurrence patterns |
| Target level | External | Retrospective dietary CRA (EC 2018) - Chronic / Tier II | Hazard characterisations |
Retrospective dietary CRA (EFSA 2012) - Optimistic
Use the optimistic model settings according to the EFSA Guidance 2012. Concentration values are sampled using a sample-based empirical distribution. Available processing factors are applied. No unit variability model should be applied.
| Name | Setting | From input tier | In module |
|---|---|---|---|
| Default concentration model | Empirical | ||
| Include MRL fallback model | false | ||
| Censored values replacement | ReplaceByZero | ||
| Sample based | true | ||
| Impute missing values from available values (if unchecked, missing values are imputed with 0) | false | ||
| Correlate imputed values with sample potency | false | ||
| Use occurrence frequencies for imputation | false | ||
| Parametric uncertainty | false | ||
| Target level | External | Retrospective dietary CRA (EFSA 2012) - Optimistic | Hazard characterisations |
Retrospective dietary CRA (EFSA 2012) - Acute / Pessimistic
Acute probabilistic exposure assessment using the pessimistic model settings according to the EFSA Guidance 2012. Only processing factors > 1 are applied. For unit variability, the Beta distribution is applied.
| Name | Setting | From input tier | In module |
|---|---|---|---|
| Default concentration model | NonDetectSpikeLogNormal | ||
| Include MRL fallback model | true | ||
| Restrict LOR imputation to authorised uses | false | ||
| Censored values replacement | ReplaceByLOR | ||
| Factor f (f x LOR or f x LOD or LOD + f x (LOQ - LOD) | 1 | ||
| MRL Factor (f x MRL) | 1 | ||
| Sample based | true | ||
| Impute missing values from available values (if unchecked, missing values are imputed with 0) | true | ||
| Correlate imputed values with sample potency | true | ||
| Parametric uncertainty | true | ||
| Filter samples exceeding the concentration limits | false | Retrospective dietary CRA (EFSA 2012) - Acute / Pessimistic | Concentrations |
| Target level | External | Retrospective dietary CRA (EFSA 2012) - Acute / Pessimistic | Hazard characterisations |
Retrospective dietary CRA (EFSA 2012) - Chronic / Pessimistic
Chronic probabilistic exposure assessment using the pessimistic model settings according to the EFSA Guidance 2012. Only processing factors > 1 are applied.
| Name | Setting | From input tier | In module |
|---|---|---|---|
| Default concentration model | NonDetectSpikeLogNormal | ||
| Include MRL fallback model | true | ||
| Restrict LOR imputation to authorised uses | false | ||
| Censored values replacement | ReplaceByLOR | ||
| Factor f (f x LOR or f x LOD or LOD + f x (LOQ - LOD) | 1 | ||
| MRL Factor (f x MRL) | 1 | ||
| Sample based | true | ||
| Impute missing values from available values (if unchecked, missing values are imputed with 0) | true | ||
| Correlate imputed values with sample potency | true | ||
| Parametric uncertainty | false | ||
| Filter samples exceeding the concentration limits | false | Retrospective dietary CRA (EFSA 2012) - Chronic / Pessimistic | Concentrations |
| Target level | External | Retrospective dietary CRA (EFSA 2012) - Chronic / Pessimistic | Hazard characterisations |
Retrospective dietary CRA (EFSA 2022) - Acute / Tier I
| Name | Setting | From input tier | In module |
|---|---|---|---|
| Default concentration model | Empirical | ||
| Include MRL fallback model | false | ||
| Restrict LOR imputation to authorised uses | false | ||
| Censored values replacement | ReplaceByLOR | ||
| Factor f (f x LOR or f x LOD or LOD + f x (LOQ - LOD) | 0.5 | ||
| Sample based | true | ||
| Impute missing values from available values (if unchecked, missing values are imputed with 0) | true | ||
| Correlate imputed values with sample potency | true | ||
| Use occurrence frequencies for imputation | true | ||
| Parametric uncertainty | false | ||
| Filter samples exceeding the concentration limits | false | Retrospective dietary CRA (EFSA 2022) - Acute / Tier I | Concentrations |
| Use substance conversion rules | true | Retrospective dietary CRA (EFSA 2022) - Acute / Tier I | Concentrations |
| Substance conversion method | UseMostToxic | Retrospective dietary CRA (EFSA 2022) - Acute / Tier I | Concentrations |
| Retain all allocated substances after active substance allocation | true | Retrospective dietary CRA (EFSA 2022) - Acute / Tier I | Concentrations |
| Account for substance authorisations in substance conversions | false | Retrospective dietary CRA (EFSA 2022) - Acute / Tier I | Concentrations |
| Fix duplicate substance allocation inconsistencies | false | Retrospective dietary CRA (EFSA 2022) - Acute / Tier I | Concentrations |
| Use extrapolation rules | false | Retrospective dietary CRA (EFSA 2022) - Acute / Tier I | Concentrations |
| Impute water concentrations | true | Retrospective dietary CRA (EFSA 2022) - Acute / Tier I | Concentrations |
| Water concentration value (µg/kg) | 0.1 | Retrospective dietary CRA (EFSA 2022) - Acute / Tier I | Concentrations |
| Restrict water imputation to the five most toxic substances | true | Retrospective dietary CRA (EFSA 2022) - Acute / Tier I | Concentrations |
| Restrict water imputation to authorised uses | false | Retrospective dietary CRA (EFSA 2022) - Acute / Tier I | Concentrations |
| Restrict water imputation to approved substances | true | Retrospective dietary CRA (EFSA 2022) - Acute / Tier I | Concentrations |
| Apply occurrence pattern percentages | false | Retrospective dietary CRA (EFSA 2022) - Acute / Tier I | Occurrence patterns |
| Target level | External | Retrospective dietary CRA (EFSA 2022) - Acute / Tier I | Hazard characterisations |
Retrospective dietary CRA (EFSA 2022) - Chronic / Tier I
| Name | Setting | From input tier | In module |
|---|---|---|---|
| Default concentration model | Empirical | ||
| Include MRL fallback model | false | ||
| Restrict LOR imputation to authorised uses | false | ||
| Censored values replacement | ReplaceByLOR | ||
| Factor f (f x LOR or f x LOD or LOD + f x (LOQ - LOD) | 0.5 | ||
| Sample based | true | ||
| Impute missing values from available values (if unchecked, missing values are imputed with 0) | true | ||
| Correlate imputed values with sample potency | true | ||
| Use occurrence frequencies for imputation | true | ||
| Parametric uncertainty | false | ||
| Filter samples exceeding the concentration limits | false | Retrospective dietary CRA (EFSA 2022) - Chronic / Tier I | Concentrations |
| Use substance conversion rules | true | Retrospective dietary CRA (EFSA 2022) - Chronic / Tier I | Concentrations |
| Substance conversion method | UseMostToxic | Retrospective dietary CRA (EFSA 2022) - Chronic / Tier I | Concentrations |
| Retain all allocated substances after active substance allocation | true | Retrospective dietary CRA (EFSA 2022) - Chronic / Tier I | Concentrations |
| Account for substance authorisations in substance conversions | false | Retrospective dietary CRA (EFSA 2022) - Chronic / Tier I | Concentrations |
| Fix duplicate substance allocation inconsistencies | false | Retrospective dietary CRA (EFSA 2022) - Chronic / Tier I | Concentrations |
| Use extrapolation rules | false | Retrospective dietary CRA (EFSA 2022) - Chronic / Tier I | Concentrations |
| Impute water concentrations | true | Retrospective dietary CRA (EFSA 2022) - Chronic / Tier I | Concentrations |
| Water concentration value (µg/kg) | 0.1 | Retrospective dietary CRA (EFSA 2022) - Chronic / Tier I | Concentrations |
| Restrict water imputation to the five most toxic substances | true | Retrospective dietary CRA (EFSA 2022) - Chronic / Tier I | Concentrations |
| Restrict water imputation to authorised uses | false | Retrospective dietary CRA (EFSA 2022) - Chronic / Tier I | Concentrations |
| Restrict water imputation to approved substances | true | Retrospective dietary CRA (EFSA 2022) - Chronic / Tier I | Concentrations |
| Apply occurrence pattern percentages | false | Retrospective dietary CRA (EFSA 2022) - Chronic / Tier I | Occurrence patterns |
| Target level | External | Retrospective dietary CRA (EFSA 2022) - Chronic / Tier I | Hazard characterisations |
Retrospective dietary CRA (EFSA 2022) - Acute / Tier II
| Name | Setting | From input tier | In module |
|---|---|---|---|
| Default concentration model | Empirical | ||
| Include MRL fallback model | false | ||
| Restrict LOR imputation to authorised uses | false | ||
| Censored values replacement | ReplaceByLOR | ||
| Factor f (f x LOR or f x LOD or LOD + f x (LOQ - LOD) | 0.5 | ||
| Sample based | true | ||
| Impute missing values from available values (if unchecked, missing values are imputed with 0) | true | ||
| Correlate imputed values with sample potency | false | ||
| Use occurrence frequencies for imputation | true | ||
| Parametric uncertainty | false | ||
| Filter samples exceeding the concentration limits | false | Retrospective dietary CRA (EFSA 2022) - Acute / Tier II | Concentrations |
| Use substance conversion rules | true | Retrospective dietary CRA (EFSA 2022) - Acute / Tier II | Concentrations |
| Substance conversion method | DrawRandom | Retrospective dietary CRA (EFSA 2022) - Acute / Tier II | Concentrations |
| Retain all allocated substances after active substance allocation | true | Retrospective dietary CRA (EFSA 2022) - Acute / Tier II | Concentrations |
| Account for substance authorisations in substance conversions | true | Retrospective dietary CRA (EFSA 2022) - Acute / Tier II | Concentrations |
| Fix duplicate substance allocation inconsistencies | false | Retrospective dietary CRA (EFSA 2022) - Acute / Tier II | Concentrations |
| Use extrapolation rules | false | Retrospective dietary CRA (EFSA 2022) - Acute / Tier II | Concentrations |
| Impute water concentrations | true | Retrospective dietary CRA (EFSA 2022) - Acute / Tier II | Concentrations |
| Water concentration value (µg/kg) | 0.05 | Retrospective dietary CRA (EFSA 2022) - Acute / Tier II | Concentrations |
| Restrict water imputation to the five most toxic substances | true | Retrospective dietary CRA (EFSA 2022) - Acute / Tier II | Concentrations |
| Restrict water imputation to authorised uses | false | Retrospective dietary CRA (EFSA 2022) - Acute / Tier II | Concentrations |
| Restrict water imputation to approved substances | true | Retrospective dietary CRA (EFSA 2022) - Acute / Tier II | Concentrations |
| Apply occurrence pattern percentages | true | Retrospective dietary CRA (EFSA 2022) - Acute / Tier II | Occurrence patterns |
| Scale up use frequency to 100% | true | Retrospective dietary CRA (EFSA 2022) - Acute / Tier II | Occurrence patterns |
| Restrict use percentage up-scaling to authorised uses | true | Retrospective dietary CRA (EFSA 2022) - Acute / Tier II | Occurrence patterns |
| Target level | External | Retrospective dietary CRA (EFSA 2022) - Acute / Tier II | Hazard characterisations |
Retrospective dietary CRA (EFSA 2022) - Chronic / Tier II
| Name | Setting | From input tier | In module |
|---|---|---|---|
| Default concentration model | Empirical | ||
| Include MRL fallback model | false | ||
| Restrict LOR imputation to authorised uses | false | ||
| Censored values replacement | ReplaceByLOR | ||
| Factor f (f x LOR or f x LOD or LOD + f x (LOQ - LOD) | 0.5 | ||
| Sample based | true | ||
| Impute missing values from available values (if unchecked, missing values are imputed with 0) | true | ||
| Correlate imputed values with sample potency | false | ||
| Use occurrence frequencies for imputation | true | ||
| Parametric uncertainty | false | ||
| Filter samples exceeding the concentration limits | false | Retrospective dietary CRA (EFSA 2022) - Chronic / Tier II | Concentrations |
| Use substance conversion rules | true | Retrospective dietary CRA (EFSA 2022) - Chronic / Tier II | Concentrations |
| Substance conversion method | DrawRandom | Retrospective dietary CRA (EFSA 2022) - Chronic / Tier II | Concentrations |
| Retain all allocated substances after active substance allocation | true | Retrospective dietary CRA (EFSA 2022) - Chronic / Tier II | Concentrations |
| Account for substance authorisations in substance conversions | true | Retrospective dietary CRA (EFSA 2022) - Chronic / Tier II | Concentrations |
| Fix duplicate substance allocation inconsistencies | false | Retrospective dietary CRA (EFSA 2022) - Chronic / Tier II | Concentrations |
| Use extrapolation rules | false | Retrospective dietary CRA (EFSA 2022) - Chronic / Tier II | Concentrations |
| Impute water concentrations | true | Retrospective dietary CRA (EFSA 2022) - Chronic / Tier II | Concentrations |
| Water concentration value (µg/kg) | 0.05 | Retrospective dietary CRA (EFSA 2022) - Chronic / Tier II | Concentrations |
| Restrict water imputation to the five most toxic substances | true | Retrospective dietary CRA (EFSA 2022) - Chronic / Tier II | Concentrations |
| Restrict water imputation to authorised uses | false | Retrospective dietary CRA (EFSA 2022) - Chronic / Tier II | Concentrations |
| Restrict water imputation to approved substances | true | Retrospective dietary CRA (EFSA 2022) - Chronic / Tier II | Concentrations |
| Apply occurrence pattern percentages | true | Retrospective dietary CRA (EFSA 2022) - Chronic / Tier II | Occurrence patterns |
| Scale up use frequency to 100% | true | Retrospective dietary CRA (EFSA 2022) - Chronic / Tier II | Occurrence patterns |
| Restrict use percentage up-scaling to authorised uses | true | Retrospective dietary CRA (EFSA 2022) - Chronic / Tier II | Occurrence patterns |
| Target level | External | Retrospective dietary CRA (EFSA 2022) - Chronic / Tier II | Hazard characterisations |
Prospective dietary CRA (EFSA 2023) - Acute / Tier II
| Name | Setting | From input tier | In module |
|---|---|---|---|
| Default concentration model | Empirical | ||
| Include MRL fallback model | false | ||
| Restrict LOR imputation to authorised uses | false | ||
| Censored values replacement | ReplaceByLOR | ||
| Factor f (f x LOR or f x LOD or LOD + f x (LOQ - LOD) | 0.5 | ||
| Sample based | true | ||
| Impute missing values from available values (if unchecked, missing values are imputed with 0) | true | ||
| Correlate imputed values with sample potency | false | ||
| Use occurrence frequencies for imputation | true | ||
| Parametric uncertainty | false | ||
| Filter samples exceeding the concentration limits | true | Prospective dietary CRA (EFSA 2023) - Acute / Tier II | Concentrations |
| Concentration limit filter exceedance factor | 2 | Prospective dietary CRA (EFSA 2023) - Acute / Tier II | Concentrations |
| Use substance conversion rules | true | Prospective dietary CRA (EFSA 2023) - Acute / Tier II | Concentrations |
| Substance conversion method | DrawRandom | Prospective dietary CRA (EFSA 2023) - Acute / Tier II | Concentrations |
| Retain all allocated substances after active substance allocation | true | Prospective dietary CRA (EFSA 2023) - Acute / Tier II | Concentrations |
| Account for substance authorisations in substance conversions | true | Prospective dietary CRA (EFSA 2023) - Acute / Tier II | Concentrations |
| Fix duplicate substance allocation inconsistencies | false | Prospective dietary CRA (EFSA 2023) - Acute / Tier II | Concentrations |
| Use extrapolation rules | false | Prospective dietary CRA (EFSA 2023) - Acute / Tier II | Concentrations |
| Impute water concentrations | true | Prospective dietary CRA (EFSA 2023) - Acute / Tier II | Concentrations |
| Water concentration value (µg/kg) | 0.05 | Prospective dietary CRA (EFSA 2023) - Acute / Tier II | Concentrations |
| Restrict water imputation to the five most toxic substances | true | Prospective dietary CRA (EFSA 2023) - Acute / Tier II | Concentrations |
| Restrict water imputation to authorised uses | false | Prospective dietary CRA (EFSA 2023) - Acute / Tier II | Concentrations |
| Restrict water imputation to approved substances | true | Prospective dietary CRA (EFSA 2023) - Acute / Tier II | Concentrations |
| Include focal commodity concentrations | true | Prospective dietary CRA (EFSA 2023) - Acute / Tier II | Concentrations |
| Focal commodity substance occurrence percentage | 20 | Prospective dietary CRA (EFSA 2023) - Acute / Tier II | Concentrations |
| Adjustment factor for the focal food/substance concentration | 1 | Prospective dietary CRA (EFSA 2023) - Acute / Tier II | Concentrations |
| Use deterministic substance conversions for focal commodity | true | Prospective dietary CRA (EFSA 2023) - Acute / Tier II | Concentrations |
| Apply occurrence pattern percentages | true | Prospective dietary CRA (EFSA 2023) - Acute / Tier II | Occurrence patterns |
| Scale up use frequency to 100% | true | Prospective dietary CRA (EFSA 2023) - Acute / Tier II | Occurrence patterns |
| Restrict use percentage up-scaling to authorised uses | true | Prospective dietary CRA (EFSA 2023) - Acute / Tier II | Occurrence patterns |
| Target level | External | Prospective dietary CRA (EFSA 2023) - Acute / Tier II | Hazard characterisations |
Prospective dietary CRA (EFSA 2023) - Chronic / Tier II
| Name | Setting | From input tier | In module |
|---|---|---|---|
| Default concentration model | Empirical | ||
| Include MRL fallback model | false | ||
| Restrict LOR imputation to authorised uses | false | ||
| Censored values replacement | ReplaceByLOR | ||
| Factor f (f x LOR or f x LOD or LOD + f x (LOQ - LOD) | 0.5 | ||
| Sample based | true | ||
| Impute missing values from available values (if unchecked, missing values are imputed with 0) | true | ||
| Correlate imputed values with sample potency | false | ||
| Use occurrence frequencies for imputation | true | ||
| Parametric uncertainty | false | ||
| Filter samples exceeding the concentration limits | true | Prospective dietary CRA (EFSA 2023) - Chronic / Tier II | Concentrations |
| Concentration limit filter exceedance factor | 2 | Prospective dietary CRA (EFSA 2023) - Chronic / Tier II | Concentrations |
| Use substance conversion rules | true | Prospective dietary CRA (EFSA 2023) - Chronic / Tier II | Concentrations |
| Substance conversion method | DrawRandom | Prospective dietary CRA (EFSA 2023) - Chronic / Tier II | Concentrations |
| Retain all allocated substances after active substance allocation | true | Prospective dietary CRA (EFSA 2023) - Chronic / Tier II | Concentrations |
| Account for substance authorisations in substance conversions | true | Prospective dietary CRA (EFSA 2023) - Chronic / Tier II | Concentrations |
| Fix duplicate substance allocation inconsistencies | false | Prospective dietary CRA (EFSA 2023) - Chronic / Tier II | Concentrations |
| Use extrapolation rules | false | Prospective dietary CRA (EFSA 2023) - Chronic / Tier II | Concentrations |
| Impute water concentrations | true | Prospective dietary CRA (EFSA 2023) - Chronic / Tier II | Concentrations |
| Water concentration value (µg/kg) | 0.05 | Prospective dietary CRA (EFSA 2023) - Chronic / Tier II | Concentrations |
| Restrict water imputation to the five most toxic substances | true | Prospective dietary CRA (EFSA 2023) - Chronic / Tier II | Concentrations |
| Restrict water imputation to authorised uses | false | Prospective dietary CRA (EFSA 2023) - Chronic / Tier II | Concentrations |
| Restrict water imputation to approved substances | true | Prospective dietary CRA (EFSA 2023) - Chronic / Tier II | Concentrations |
| Include focal commodity concentrations | true | Prospective dietary CRA (EFSA 2023) - Chronic / Tier II | Concentrations |
| Focal commodity substance occurrence percentage | 20 | Prospective dietary CRA (EFSA 2023) - Chronic / Tier II | Concentrations |
| Adjustment factor for the focal food/substance concentration | 1 | Prospective dietary CRA (EFSA 2023) - Chronic / Tier II | Concentrations |
| Use deterministic substance conversions for focal commodity | true | Prospective dietary CRA (EFSA 2023) - Chronic / Tier II | Concentrations |
| Apply occurrence pattern percentages | true | Prospective dietary CRA (EFSA 2023) - Chronic / Tier II | Occurrence patterns |
| Scale up use frequency to 100% | true | Prospective dietary CRA (EFSA 2023) - Chronic / Tier II | Occurrence patterns |
| Restrict use percentage up-scaling to authorised uses | true | Prospective dietary CRA (EFSA 2023) - Chronic / Tier II | Occurrence patterns |
| Target level | External | Prospective dietary CRA (EFSA 2023) - Chronic / Tier II | Hazard characterisations |