Hazard characterisations settings
Selection settings
| Name | Type | Description |
|---|---|---|
Exposure type
|
ExposureType | The type of exposure considered in the assessment; acute (short term) or chronic (long-term). |
Multiple effects analysis
|
Boolean |
Specifies whether the analysis should consider multiple effects. Otherwise, a single focal effect should be selected. |
Target level
|
TargetLevelType | Select to express hazard characterisations at external or internal exposure level. For an aggregate assessment, that is dietary and nondietary exposure data are combined, the target dose level is always internal. When only dietary exposures are available, the target dose level is optional, i.c. external or internal. |
Consider critical effect
|
Boolean |
Specifies whether the analysis should look at critical effects such as specified in the Hazard characterisation data source. |
Restrict active substances to substances with available hazard characterisations
|
Boolean |
Restrict assessment group membership based on presence/absence of hazard characterisations. |
Include related effects of AOP network
|
Boolean |
Include all related key events of the AOP network. |
Calculation settings
| Name | Type | Description |
|---|---|---|
Selected tier
|
SettingsTemplateType |
Specifies all module settings should be set according to a pre-defined tier or using custom settings. |
Seed for pseudo-random number generator
|
Numeric |
A value of 0 will use a pseudo-random seed in each run, a value > 0 will provide the same results in a repeated run. |
Index substance
|
AlphaNumeric |
The substance of interest or index substance. |
Multiple substances analysis
|
Boolean |
Specifies whether the assessment involves multiple substances. |
Point of departure source
|
TargetDosesCalculationMethod | Point of departure source for computing the hazard characterisations: from points of departure (data), dose response models or both. |
Include dietary and non-dietary routes of exposure
|
Boolean |
Specifies whether the assessment involves both dietary and non-dietary (oral, inhalatory or dermal) routes of exposure. |
Apply kinetic conversions
|
Boolean |
Convert substance concentrations from other biological matrices using kinetic conversion models. The substances for conversion are designated within the kinetic models module. Substance conversion proves valuable when a biomarker was not directly measured for a matrix of interest. |
Restrict to single target
|
Boolean |
Restrict to one biological matrix when computing substance hazard characterisations at the internal level. |
Target biological matrix
|
BiologicalMatrix | The target biological matrix (internal compartment) for which exposures are computed. |
Specify the type of kinetic model
|
InternalModelType | Specify the type of model to convert external exposure to the internal level. |
Expression type
|
PointOfDeparture | Specifies how hazard characterisations are expressed: as BMD, as NOAEL, or the expression type is ignored. |
Selection method in case of multiple candidate hazard characterisations
|
TargetDoseSelectionMethod | Choose either the most toxic (default) or an aggregated hazard characterisation when in nominal runs there are multiple available candidates. In uncertainty runs, multiple candidates are resampled. |
Impute missing hazard characterisations
|
Boolean |
If checked, missing hazard characterisations are imputed based on Munro NOELs or on other available points of departure. |
Imputation method
|
HazardDoseImputationMethodType | Imputation of Hazard characterisations: use low percentile (P5) or unbiased central estimate from either the Munro set or the available POD collection. |
Use lower limit of BMD
|
Boolean |
Use the lower uncertainty limit of the benchmark dose. For an uncertainty run, the lower limit is the p5 of the bootstrap sample, otherwise it is a parametric estimate based on the parameters of the dose response curve. |
Use inter-species conversions
|
Boolean |
Use inter-species conversion factors (default value, e.g. 10, or data). |
Use intra-species factors
|
Boolean |
Use intra-species conversion factors (default value, e.g. 10, or data). |
Additional assessment factor
|
Numeric |
Additional assessment factor for extrapolation of PODs to (human) hazard characterisations. |
Use additional assessment factor
|
Boolean |
Use additional assessment factor for extrapolation of PODs to (human) hazard characterisations. |
Use hazard characterisations subgroup
|
Boolean |
Hazard characterisations are dependent on subgroups (e.g. based on age or gender, see dataformats HCSubgroups). |
Uncertainty settings
| Name | Type | Description |
|---|---|---|
Resample intra-species factor
|
Boolean |
Specifies whether intra-species factors are resampled from a parametric uncertainty distribution. |
Resample hazard characterisations or RPFs
|
Boolean |
Specifies whether to resample the hazard characterisations or relative potency factors. Requires hazard characterisation or RPF uncertainty to be quantified in DoseResponseModelsUncertain or RelativePotencyFactorsUncertain tables. |
Lower uncertainty limit (%)
|
Numeric |
Percentage lower bound, e.g. 2.5%. |
Upper uncertainty limit (%)
|
Numeric |
Percentage upper bound, e.g. 97.5%. |