Internal exposures
Exposures are amounts of substances, typically expressed per mass unit and per day, to which individuals in a population are exposed at a chosen target level. This target level is an internal exposure (expressed per unit organ weight). Internal exposures may be aggregated from dietary and non-dietary exposures using either absorption factors, kinetic conversion factors or PBK models to translate the external exposures to internal exposures. Exposures can be short-term/acute exposures and then contain exposures for individual-days, or they can be long-term/chronic exposures, in which case they represent the average exposure per day over an unspecified longer time period.
This module has as primary entities: Populations Foods Substances
Output of this module is used by: Exposure mixtures Biological matrix concentration comparisons Risks
Calculation of internal exposures
Exposures are computed by linking dietary and (if available) non-dietary individual/individual-day exposures and computing the (aggregated) internal exposures at the specified target compartment.
Inputs used: Dietary exposures Non-dietary exposures Active substances Relative potency factors Absorption factors Kinetic conversion factors PBK models
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