Hazard characterisations data formats
Hazard characterisations provide reference threshold values associated with the hazard of interest. Examples are health-based guidance values such as ADI or ARfD, and points of departure such as BMD or NOAEL. Hazard characterisations may be dependent on e.g. age (or gender not implemented yet)
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Hazard characterisations
Hazard characterisations are specified for combinations of hazard characterisation type, effect, substance, population type, target level, and exposure route (for external) or target organ (for internal). Effects can be specific, but can also be labelled as being the critical effect and used as such if this has been specified in the hazard characterisation settings.
Accepted table names: HazardCharacterisations.
| Name | Type | Description | Aliases | Required |
|---|---|---|---|---|
idHazardCharacterisation |
AlphaNumeric (50) |
Id of the hazard characterisation. |
id, idHazardCharacterisation |
Yes |
idEffect |
AlphaNumeric (50) |
Code of the (critical) effect linked to this hazard characterisation. |
idEffect, EffectId, Effect, EffectCode |
No |
idSubstance |
AlphaNumeric (50) |
The code of the substance. |
idSubstance, SubstanceCode, SubstanceId, Substance |
Yes |
idPopulationType |
AlphaNumeric (50) |
The code of the population type for which this reference value is defined. If not specified, PS06A, Consumers is assumed. |
idPopulationType, PopulationType, PopulationGroup, PopulationSubgroup |
No |
TargetLevel |
TargetLevelType | The target level. I.e., internal or external. If omitted, external is assumed |
TargetLevel |
No |
ExposureRoute |
ExposureRouteType | The exposure route (only applicable if target level is external). If not specified, Dietary is assumed. |
ExposureRoute |
No |
Matrix |
BiologicalMatrix | The biological matrix or organ (should be specified when target level is internal). |
Matrix, BiologicalMatrix |
No |
Expression type |
ExpressionType | The expression type for (internal) hazard characterisations of which the concentrations are not directly specified at the level of the biological matrix. For instance, urinary expressions expressed in terms of the amount excreted per gram of creatinine or blood concentration expressed per gram of lipids. |
ExpressionType |
No |
IsCriticalEffect |
Boolean |
Specifies whether this value is the value associated with the critical effect. If omitted, No is assumed |
IsCriticalEffect |
No |
ExposureType |
ExposureType | The exposure type associated with the hazard characterisation (i.e., chronic or acute). |
ExposureType |
Yes |
HazardCharacterisationType |
HazardCharacterisationType | The type of the hazard characterisation (e.g., ARfD, ADI, NOAEL, BMD). |
HazardCharacterisationType |
Yes |
Qualifier |
ValueQualifier | Qualifier of the hazard characterisation value, e.g. equal-to (=) or smaller-than (<). If omitted, = is assumed. |
QualifierType |
No |
Value |
Numeric |
Reference value that characterises the hazard. |
Value, HazardCharacterisationValue |
Yes |
DoseUnit |
DoseUnit | Unit of the hazard characterisation value. |
DoseUnit, Unit |
Yes |
idPointOfDeparture |
AlphaNumeric (50) |
The code of the point of departure from which this hazard characterisation was derived. |
idHazardDose, idPod |
No |
CombinedAssessmentFactor |
Numeric |
Combined assessment factor (includes, e.g., safety factor, but also other extrapolation factors that may be used to derive the hazard characterisation from the underlying PoD). |
CombinedAssessmentFactor, AssessmentFactor, UncertaintyFactor |
No |
PublicationTitle |
AlphaNumeric (250) |
Title of the publication of the study in which this hazard characterisation was established. |
PublicationTitle, Title |
No |
PublicationAuthors |
AlphaNumeric |
Author(s) of the publication of the study in which this hazard characterisation was established. |
PublicationAuthors, PublicationAuthor, Author, Authors |
No |
PublicationYear |
Integer |
Year of the publication of the study in which this hazard characterisation was established. |
PublicationYear, Year |
No |
PublicationUri |
AlphaNumeric |
Uniform resource identifier of the reference publication. |
URI, URL, PublicationURI, PublicationURL |
No |
Name |
AlphaNumeric (100) |
Name of the hazard characterisation. |
Name |
No |
Description |
AlphaNumeric (200) |
Additional description of the hazard characterisation. |
Description |
No |
Hazard characterisations uncertainty
Often, the hazard characterisations found for a substance are uncertain. This table facilitates in specifying the hazard characterisation uncertainty in the form of a set of uncertainty values that may additionally be specified for a hazard characterisation model - substance combination.
Accepted table names: HazardCharacterisationsUncertain, HazardCharacterisationsUncertai, HazardDoseUncertain, HCUncertain.
| Name | Type | Description | Aliases | Required |
|---|---|---|---|---|
idHazardCharacterisation |
AlphaNumeric (50) |
The hazard characterisation model code (must correspond to values in id column of Hazard characterisations table). |
idHazardCharacterisation |
Yes |
idSubstance |
AlphaNumeric (50) |
The code of the substance. |
idSubstance, SubstanceId, SubstanceCode, Substance |
Yes |
HazardCharacterisationValue |
Numeric |
Reference value that characterises the hazard. |
HazardCharacterisation, HazardCharacterisationValue |
Yes |
Hazard characterisations subgroups
Hazard characterisations are dependent on e.g. age.
Accepted table names: HCSubgroups, HCSubgroup.
| Name | Type | Description | Aliases | Required |
|---|---|---|---|---|
idSubgroup |
AlphaNumeric (50) |
The id of the subgroup. |
idSubgroup |
Yes |
idHazardCharacterisation |
AlphaNumeric (50) |
Id of the hazard characterisation. |
idHazardCharacterisation |
Yes |
idSubstance |
AlphaNumeric (50) |
The code of the substance. |
idSubstance, SubstanceId, SubstanceCode |
Yes |
AgeLower |
Numeric (50) |
Specifies the lower bound of the age interval (in years) of the hazard characterisation subgroup. Individuals belong to a subgroup when the age of the individual is equal or greater than the specified lower bound and smaller than the specified lower age of the next subgroup. |
AgeLower, LowerAge |
No |
Gender |
GenderType | The gender of the subgroup. |
Gender |
No |
Value |
AlphaNumeric (50) |
The hazard characterisation of the subgroup. |
Value |
Yes |
Hazard characterisations subgroups uncertainty sets
Hazard characterisations are dependent on e.g. age and may be uncertain.
Accepted table names: HCSubgroupsUncertain, HCSubgroupUncertain.
| Name | Type | Description | Aliases | Required |
|---|---|---|---|---|
idSubgroup |
AlphaNumeric (50) |
The id of the subgroup. |
idSubgroup |
Yes |
idHazardCharacterisation |
AlphaNumeric (50) |
Id of the hazard characterisation. |
idHazardCharacterisation |
Yes |
idUncertaintySet |
AlphaNumeric (50) |
The id of the ucertainty set. |
idUncertaintySet, idUncertaintySet, idUncertainty |
Yes |
Value |
AlphaNumeric (50) |
The uncertain hazard characterisation of the subgroup. |
Value |
Yes |