EU acute cumulative exposure assessment (2018) Tier I and Tier II

This standard action is of type: Dietary exposures

This standard action is based on done in 2018 [van Klaveren et al., 2019a]. In the context of the second framework partnership agreement between the National Institute for Public Health and the Environment of the Netherlands (RIVM) and the European Food Safety Authority (EFSA) acute cumulative dietary exposure assessments were performed for two cumulative assessment groups (CAGs) of pesticides that affect the nervous system: pesticides causing brain and/or erythrocyte AChE inhibition (CAG-NAN, 47 pesticides) and pesticides causing functional alterations of the motor division (CAG-NAM, 100 pesticides). The exposure assessments used monitoring data collected by the Netherlands under their official monitoring programmes in 2014, 2015 and 2016 and individual Dutch food consumption data. Exposure estimates were obtained for each group of pesticides using the MCRA software. The Standing Committee on Plants, Animals, Food and Feed (SC PAFF) discussed the scope of the assessment in 2018 and agreed on the parameters to be used for the cumulative exposure assessment. Based on that discussion, a very conservative tier I modelling approach and a refined, but still conservative tier II modelling approach were used. In these assessments, common risk assessment practice was followed and the cumulative exposure was expressed as the total margin of exposure (MOET) at the 50th, 90th, 95th, 99th and 99.9th percentile of the exposure distribution.

Table 200 Datasources for EU acute cumulative exposure assessment (2018) Tier I and Tier II.

Table Group	Name	Repository	Type
AssessmentGroupMemberships	SecondaryInputData.mdb	Standard Actions/Cumulative Exposure Assessment/EU Acute Cumulative Exposure Assessment	Fixed
AuthorisedUses	SecondaryInputData.mdb	Standard Actions/Cumulative Exposure Assessment/EU Acute Cumulative Exposure Assessment	Fixed
Compounds	SecondaryInputData.mdb	Standard Actions/Cumulative Exposure Assessment/EU Acute Cumulative Exposure Assessment	Fixed
Concentrations	a_ConcentrationsSSD_NAN.mdb	Standard Actions/Cumulative Exposure Assessment/EU Acute Cumulative Exposure Assessment	Variable
Concentrations	a_ConcentrationsSSD_NAM.mdb	Standard Actions/Cumulative Exposure Assessment/EU Acute Cumulative Exposure Assessment	Variable
Effects	SecondaryInputData.mdb	Standard Actions/Cumulative Exposure Assessment/EU Acute Cumulative Exposure Assessment	Fixed
FoodExtrapolations	SecondaryInputData.mdb	Standard Actions/Cumulative Exposure Assessment/EU Acute Cumulative Exposure Assessment	Fixed
FoodTranslations	SecondaryInputData.mdb	Standard Actions/Cumulative Exposure Assessment/EU Acute Cumulative Exposure Assessment	Fixed
Foods	SecondaryInputData.mdb	Standard Actions/Cumulative Exposure Assessment/EU Acute Cumulative Exposure Assessment	Fixed
HazardDoses	SecondaryInputData.mdb	Standard Actions/Cumulative Exposure Assessment/EU Acute Cumulative Exposure Assessment	Fixed
MaximumResidueLimits	SecondaryInputData.mdb	Standard Actions/Cumulative Exposure Assessment/EU Acute Cumulative Exposure Assessment	Fixed
Processing	SecondaryInputData.mdb	Standard Actions/Cumulative Exposure Assessment/EU Acute Cumulative Exposure Assessment	Fixed
ResidueDefinitions	SecondaryInputData.mdb	Standard Actions/Cumulative Exposure Assessment/EU Acute Cumulative Exposure Assessment	Fixed
Survey	a_ConsumptionsNL2.mdb	Standard Actions/Cumulative Exposure Assessment/EU Acute Cumulative Exposure Assessment	Fixed
Survey	a_ConsumptionsNL3_6.mdb	Standard Actions/Cumulative Exposure Assessment/EU Acute Cumulative Exposure Assessment	Fixed
UnitVariability	UnitVarPrimo.mdb	Standard Actions/Cumulative Exposure Assessment/EU Acute Cumulative Exposure Assessment	Variable
UnitVariability	UnitVar36.mdb	Standard Actions/Cumulative Exposure Assessment/EU Acute Cumulative Exposure Assessment	Variable