Hazard characterisations

Hazard characterisations are benchmark doses for active substances and for the chosen effect at the chosen target level (external or internal) of the hazard assessment. Hazard characterisations are based on points of departure, such as BMDs from dose-response models or externally specified points of departure (MDSs, NOAELs or LOAELs). The computation may involve inter-species conversion, intra-species factors and the use of kinetic models or absorption factors to convert external doses to internal doses.

This module has as primary entities: Substances Effects

Output of this module is used by: Active substances Relative potency factors Risks Single value risks

Hazard characterisations as data

Hazard characterisations are provided as data e.g., in the form of ADIs or ARfDs that should be used for risk assessments.

• Hazard characterisations data formats

Inputs used: AOP networks Active substances Points of departure

Calculation of hazard characterisations

Hazard characterisations are computed from points of departure.

• Hazard characterisations calculation

Inputs used: Dose response models Effect representations Inter-species conversions Intra species factors Kinetic models

Settings used

• Calculation Settings

Settings and Tiers

• Hazard characterisations settings
  • Selection settings
  • Uncertainty settings