Effects data formats

Effects

Effects are primary entities of the data model. Health effects are defined as (critical) changes relative to a treatment or exposure.

Effects

Effects are uniquely identified by a code (idEffect). Optionally, a name and description can be added. Health effects are commonly distinguished in two types, acute and chronic. Further properties may be specified, e.g. in relation to decision schemes such as the use of thresholds of toxicological concern (TTCs).

Table aliases: Effects, Effect, KeyEvents, KeyEvent.

Table 1 Table definition for Effects.
Name Type Description Aliases Required

idEffect

AlphaNumeric(50)

Unique identification code of the effect.

idEffect, EffectId, CodeEffect, Id, Code, KeyEvent, idKeyEvent

Yes

CodeSystem

AlphaNumeric(100)

Identifier of the coding system of the effect code.

CodeSystem

No

Name

AlphaNumeric(100)

Name of the effect.

Name

No

Description

AlphaNumeric(200)

Additional description or label of the effect.

Description

No

BiologicalOrganisation

AlphaNumeric(100)

Biological organisation of the effect: Molecular, Cellular, Tissue, Organ, Individual. This is in line with AOP wiki terminology and can be used for grouping.

BiologicalOrganisation

No

KeyEventProcess

AlphaNumeric(100)

Description of AOP Key event component process. E.g., receptor signalling.

Process

No

KeyEventObject

AlphaNumeric(100)

Description of AOP Key event component object. E.g., PPAR-alpha.

Object

No

KeyEventAction

AlphaNumeric(100)

Description of AOP Key event component action. E.g., decreased.

Action

No

KeyEventOrgan

AlphaNumeric(100)

Description of AOP Key event organ. E.g., liver.

Organ

No

KeyEventCell

AlphaNumeric(100)

Description of AOP Key event organ. E.g., hepatocyte.

Cell

No

AOPwikiKE

AlphaNumeric(200)

Key event ID number in AOP wiki https://aopwiki.org/events Several ID possible Some effects might not be in the wiki, and this field will be empty.

AOPWikiIds, AOPwikiKE

No

Reference

AlphaNumeric(200)

External reference(s) to sources containing more information about the AOP key event. E.g., the AOP wiki, and the associated AOP wiki Ids.

References

No