Unit definitions

Benchmark response types

Accepted benchmark response types.

Table 183 Unit definition for Benchmark response types.

Name	Short name	Aliases	Description
Fraction change	Fraction change	FractionChange, FactorChange	The benchmark response is defined as a fraction change of the background response (i.e., defined for both increase and decrease). E.g., for a factor of 0.1, the benchmark response is at +/- 10% of background response.
Percentage change	Percentage change	PercentageChange	The benchmark response is defined as a percentage change of the background response (i.e., defined for both increase and decrease). E.g., for a percentage of 10, the benchmark response is at +/- 10% of background response.
Fraction of background response	Fraction of background	Factor, FactorOfBackground	The benchmark response is defined as a fraction of the background response. E.g., for a factor of 0.9, the benchmark response is at 0.9 times the background response (i.e., a decrease).
Percentage of background response	Percentage of background	Percentage, PercentageOfBackground	The benchmark response is defined as a percentage of the background response. E.g., for a percentage of 90, the benchmark response is at 90% of the background response (i.e., a decrease).
Extra risk	ER	ExtraRisk	For quantal response types. The benchmark dose is defined as the dose that corresponding with an extra risk of a factor times the background risk. A factor of 0.05 corresponds with 5% extra risk.
Additional risk	AR	AdditionalRisk	For quantal response types. The benchmark dose is defined as the dose that corresponding with an additional risk of a factor times the background risk. A factor of 0.05 corresponds with 5% additional risk.
ED50	ED50	ED50	For quantal response types. The benchmark dose is defined as the dose that corresponds with an estimated risk of 50% (ED50).
Absolute threshold value	Threshold value	Absolute	The benchmark dose is defined as an absolute threshold value.
Absolute difference	Absolute difference	Difference	The benchmark dose is defined an absolute difference with the background risk.

Body weight units

Units for describing person body weights.

Table 184 Unit definition for Body weight units.

Name	Short name	Aliases
Kilogram	kg	kg, kilograms, kilogr, 3, G167A
Gram	g	g, grams, gr, 0, G148A

Concentration units

Units for describing substance concentrations.

Table 185 Unit definition for Concentration units.

Name	Short name	Aliases
kilogram/kilogram	kg/kg	kg/kg, kilogram/kilogram, kilogram/kg, 0, G063A
gram/kilogram	g/kg	g/kg, gram/kilogram, gram/kg, gr/kg, -3, G015A, G060A, G191A
milligram/kilogram	mg/kg	mg/kg, milligram/kilogram, milligram/kg, milligr/kg, -6, G049A, G061A
microgram/kilogram	µg/kg	µg/kg, ug/kg, microgram/kilogram, microgram/kg, microgr/kg, -9, G050A, G076A
nanogram/kilogram	ng/kg	ng/kg, nanogram/kilogram, nanogram/kg, nanogr/kg, -12, G077A, G080A
picogram/kilogram	pg/kg	pg/kg, picogram/kilogram, picogram/kg, picogr/kg, -15, G081A
kilogram/liter	kg/L	kg/l, kg/L, kilogram/liter, kilogram/litre, G017A
gram/liter	g/L	g/l, g/L, gram/liter, gram/litre, gr/l, gr/L, G016A
milligram/liter	mg/L	mg/l, mg/L, milligram/liter, milligram/litre, milligr/l, milligr/L, G052A, G062A
microgram/liter	µg/L	µg/l, ug/L, microgram/liter, microgram/litre, microgr/l, microgr/L, G051A, G079A
nanogram/liter	ng/L	ng/l, ng/L, nanogram/liter, nanogram/litre, nanogr/l, nanogr/L, G078A
picogram/liter	pg/L	pg/l, pg/L, picogram/liter, picogram/litre, picogr/l, picogr/L
microgram/milliliter	µg/mL	µg/ml, ug/mL, microgram/milliliter, microgram/millilitre, microgr/ml, microgr/mL
nanogram/milliliter	ng/mL	ng/ml, ng/mL, nanogram/milliliter, nanogram/millilitre, nanogr/ml, nanogr/mL

Consumption units

Units for consumption amounts.

Table 186 Unit definition for Consumption units.

Name	Short name	Aliases
kilogram	kg	kg, kilograms, kilogr, 3, G167A
Gram	g	g, grams, gr, 0, G148A

Dose response model types

Known dose response model types.

Table 187 Unit definition for Dose response model types.

Name	Short name	Aliases	Description
Exp-m1	Exp-m1	Expm1
Exp-m2	Exp-m2	Expm2
Exp-m3	Exp-m3	Expm3
Exp-m4	Exp-m4	Expm4
Exp-m5	Exp-m5	Expm5
Hill-m1	Hill-m1	Hillm1
Hill-m2	Hill-m2	Hillm2
Hill-m3	Hill-m3	Hillm3
Hill-m4	Hill-m4	Hillm4
Hill-m5	Hill-m5	Hillm5
TwoStage	TwoStage	TwoStage
LogLogist	LogLogist	LogLogist
Weibull	Weibull	Weibull
LogProb	LogProb	LogProb
Gamma	Gamma	Gamma
Logistic	Logistic	Logistic
Probit	Probit	Probit
LVM Exp m2	LVM Exp m2	LVM Exp m2
LVM Exp m3	LVM Exp m3	LVM_Exp_M3
LVM Exp m4	LVM Exp m4	LVM_Exp_M4
LVM Exp m5	LVM Exp m5	LVM_Exp_M5
LVM Hill m2	LVM Hill m2	LVM Hill m2
LVM Hill m3	LVM Hill m3	LVM_Hill_M3
LVM Hill m4	LVM Hill m4	LVM_Hill_M4
LVM Hill m5	LVM Hill m5	LVM Hill m5

Dose units

Units for describing substance doses.

Table 188 Unit definition for Dose units.

Name	Short name	Aliases
gram/kilogram bodyweight/day	g/kg bw/day	g/kg bw/day, gram/kg bw/day, gr/kg bw/day
milligram/kilogram bodyweight/day	mg/kg bw/day	mg/kg bw/day, milligram/kg bw/day, milligr/kg bw/day, G211A
microgram/kilogram bodyweight/day	µg/kg bw/day	µg/kg bw/day, microgram/kg bw/day, microgr/kg bw/day
nanogram/kilogram bodyweight/day	ng/kg bw/day	ng/kg bw/day, nanogram/kg bw/day, nanogr/kg bw/day
picogram/kilogram bodyweight/day	pg/kg bw/day	pg/kg bw/day, picogram/kg bw/day, picogr/kg bw/day
femtogram/kilogram bodyweight/day	fg/kg bw/day	fg/kg bw/day, femtogram/kg bw/day, femtogr/kg bw/day
gram/gram bodyweight/day	g/g bw/day	g/g bw/day, gram/g bw/day, gr/g bw/day
milligram/gram bodyweight/day	mg/g bw/day	mg/g bw/day, milligram/g bw/day, milligr/g bw/day
microgram/gram bodyweight/day	µg/g bw/day	µg/g bw/day, microgram/g bw/day, microgr/g bw/day
nanogram/gram bodyweight/day	ng/g bw/day	ng/g bw/day, nanogram/g bw/day, nanogr/g bw/day
picogram/gram bodyweight/day	pg/g bw/day	pg/g bw/day, picogram/g bw/day, picogr/g bw/day
femtogram/gram bodyweight/day	fg/g bw/day	fg/g bw/day, femtogram/g bw/day, femtogr/g bw/day
kilogram/day	kg/day	kg/day, kilogram/day, kilogr/day
gram/day	g/day	g/day, gram/day, gr/day
milligram/day	mg/day	mg/day, milligram/day, milligr/day
microgram/day	µg/day	µg/day, microgram/day, microgr/day
nanogram/day	ng/day	ng/day, nanogram/day, nanogr/day
picogram/day	pg/day	pg/day, picogram/day, picogr/day
femtogram/day	fg/day	fg/day, femtogram/day, femtogr/day
kilogram/kilogram	kg/kg	kg/kg, kilogram/kilogram, kilogram/kg, kg/kg bw
gram/kilogram	g/kg	g/kg, gram/kilogram, gram/kg, gr/kg, g/kg bw
milligram/kilogram	mg/kg	mg/kg, milligram/kilogram, milligram/kg, milligr/kg, mg/kg bw, G225A
microgram/kilogram	µg/kg	µg/kg, microgram/kilogram, microgram/kg, microgr/kg, µg/kg bw
nanogram/kilogram	ng/kg	ng/kg, nanogram/kilogram, nanogram/kg, nanogr/kg, ng/kg bw
picogram/kilogram	pg/kg	pg/kg, picogram/kilogram, picogram/kg, picogr/kg, pg/kg bw
Molar	M	M, mol/L
millimolar	mM	mM, mmol/L
micromolar	µM	uM, µM, umol/L
nanomolar	nM	nM, nmol/L
moles	moles	moles, Moles
millimoles	mmoles	mmoles, mMoles
micromoles	µmoles	umoles, uMoles
nanomoles	nmoles	nmoles, nMoles

Exposure route types

The different routes in which an individual is exposed to substance concentrations.

Table 189 Unit definition for Exposure route types.

Name	Short name	Aliases	Description
Dietary exposure	Dietary	Dietary	Dietary exposure.
Non-dietary oral exposure	Oral	Oral	Non-dietary oral exposure.
Non-dietary dermal exposure	Dermal	Dermal	Non-dietary dermal exposure.
Non-dietary inhalation exposure	Inhalation	Inhalation	Non-dietary inhalation exposure.
At target	At target	AtTarget	Exposures directly at the target (organ).

Exposure types

The different types of exposure. I.e., acute or chronic.

Table 190 Unit definition for Exposure types.

Name	Short name	Aliases	Description
Acute	Acute	Acute	Acute exposure.
Chronic	Chronic	Chronic	Chronic exposure.

Exposure units

Units for describing substance exposures.

Table 191 Unit definition for Exposure units.

Name	Short name	Aliases
gram/kilogram bodyweight/day	g/kg bw/day	g/kg bw/day, gram/kg bw/day, gr/kg bw/day, G212A
milligram/kilogram bodyweight/day	mg/kg bw/day	mg/kg bw/day, milligram/kg bw/day, milligr/kg bw/day, G211A
microgram/kilogram bodyweight/day	µg/kg bw/day	µg/kg bw/day, microgram/kg bw/day, microgr/kg bw/day, G210A
nanogram/kilogram bodyweight/day	ng/kg bw/day	ng/kg bw/day, nanogram/kg bw/day, nanogr/kg bw/day, G214A
picogram/kilogram bodyweight/day	pg/kg bw/day	pg/kg bw/day, picogram/kg bw/day, picogr/kg bw/day
femtogram/kilogram bodyweight/day	fg/kg bw/day	fg/kg bw/day, femtogram/kg bw/day, femtogr/kg bw/day
gram/gram bodyweight/day	g/g bw/day	g/g bw/day, gram/g bw/day, gr/g bw/day
milligram/gram bodyweight/day	mg/g bw/day	mg/g bw/day, milligram/g bw/day, milligr/g bw/day
microgram/gram bodyweight/day	µg/g bw/day	µg/g bw/day, microgram/g bw/day, microgr/g bw/day
nanogram/gram bodyweight/day	ng/g bw/day	ng/g bw/day, nanogram/g bw/day, nanogr/g bw/day
picogram/gram bodyweight/day	pg/g bw/day	pg/g bw/day, picogram/g bw/day, picogr/g bw/day
femtogram/gram bodyweight/day	fg/g bw/day	fg/g bw/day, femtogram/g bw/day, femtogr/g bw/day
kilogram/day	kg/day	kg/day, kilogram/day, kilogr/day
gram/day	g/day	g/day, gram/day, gr/day
milligram/day	mg/day	mg/day, milligram/day, milligr/day
microgram/day	µg/day	µg/day, microgram/day, microgr/day
nanogram/day	ng/day	ng/day, nanogram/day, nanogr/day
picogram/day	pg/day	pg/day, picogram/day, picogr/day
femtogram/day	fg/day	fg/day, femtogram/day, femtogr/day
gram/kilogram	g/kg	g/kg, gram/kg, gr/kg, G015A
milligram/kilogram	mg/kg	mg/kg, milligram/kg, milligr/kg, G061A
microgram/kilogram	µg/kg	µg/kg, microgram/kg, microgr/kg, G050A
nanogram/kilogram	ng/kg	ng/kg, nanogram/kg, nanogr/kg, G077A
picogram/kilogram	pg/kg	pg/kg, picogram/kg, picogr/kg, G081A
femtogram/kilogram	fg/kg	fg/kg, femtogram/kg, femtogr/kg
gram	g	g, gram, gr, G148A
milligram	mg	mg, milligram, milligr, G155A
microgram	µg	µg, microgram, microgr
nanogram	ng	ng, nanogram, nanogr, G120A
picogram	pg	pg, picogram, picogr, G125A
femtogram	fg	fg, femtogram, femtogr

Hazard characterisation types

Known hazard characterisation types.

Table 192 Unit definition for Hazard characterisation types.

Name	Short name	Aliases
Benchmark dose	BMD	BMD
No observed adverse effect level	NOAEL	NOAEL
Lowest observed adverse effect level	LOAEL	LOAEL
Acceptable daily intake	ADI	ADI
Acute reference dose	ARfD	ARfD
No observed effect level	NOEL	NOEL

Point of departure types

Known point of departure types.

Table 193 Unit definition for Point of departure types.

Name	Short name	Aliases	Description
Benchmark dose	BMD	BMD
No observed adverse effect level	NOAEL	NOAEL
Lowest observed adverse effect level	LOAEL	LOAEL
No observed effect level	NOEL	NOEL
LD50	LD50	LD50	Median lethal dose.

Response types

Available response types.

Table 194 Unit definition for Response types.

Name	Short name	Aliases	Description
Continuous multiplicative	CM	ContinuousMultiplicative	Response values are positive real numbers, e.g., weight, size.
Continuous additive	CA	ContinuousAdditive	Response values are real numbers, e.g., weight change, temperature.
Binary	B	Binary	Response values have binary outcomes (yes/no, true/false, success/failure, 0/1, etc.).
Quantal	Q	Quantal, Binomial	Response is measured in terms of number of successes out of N possible.
Quantal group	QG	QuantalGroup	Individual responses are measured as binary values, which may be grouped to form a quantal response.
Count	C	Count	Number of items (cells, molecules, deaths, etc.) in given interval/area/volume.
Ordinal	O	Ordinal	Relative scores (or graded scores) useable only for ranking.

Target dose level types

This unit specifies whether a dose is assumed to be an internal or external dose.

Table 195 Unit definition for Target dose level types.

Name	Short name	Aliases	Description
External	Ext	External, Ext	External exposure.
Internal	Int	Internal, Int	Internal exposure.

Test system types

Available test system types.

Table 196 Unit definition for Test system types.

Name	Short name	Aliases	Description
In vivo	In vivo	InVivo	In vivo
Cell line	Cell line	CellLine	CellLine
Primary cells	Primary cells	PrimaryCells	PrimaryCells
Tissue	Tissue	Tissue	Tissue
Organ	Organ	Organ	Organ