Benchmark response types

Accepted benchmark response types.

Table 165 Unit definition for Benchmark response types.
Name Short name Aliases Description

Fraction change

Fraction change

FractionChange, FactorChange

The benchmark response is defined as a fraction change of the background response (i.e., defined for both increase and decrease). E.g., for a factor of 0.1, the benchmark response is at +/- 10% of background response.

Percentage change

Percentage change

PercentageChange

The benchmark response is defined as a percentage change of the background response (i.e., defined for both increase and decrease). E.g., for a percentage of 10, the benchmark response is at +/- 10% of background response.

Fraction of background response

Fraction of background

Factor, FactorOfBackground

The benchmark response is defined as a fraction of the background response. E.g., for a factor of 0.9, the benchmark response is at 0.9 times the background response (i.e., a decrease).

Percentage of background response

Percentage of background

Percentage, PercentageOfBackground

The benchmark response is defined as a percentage of the background response. E.g., for a percentage of 90, the benchmark response is at 90% of the background response (i.e., a decrease).

Extra risk

ER

ExtraRisk

For quantal response types. The benchmark dose is defined as the dose that corresponding with an extra risk of a factor times the background risk. A factor of 0.05 corresponds with 5% extra risk.

Additional risk

AR

AdditionalRisk

For quantal response types. The benchmark dose is defined as the dose that corresponding with an additional risk of a factor times the background risk. A factor of 0.05 corresponds with 5% additional risk.

ED50

ED50

ED50

For quantal response types. The benchmark dose is defined as the dose that corresponds with an estimated risk of 50% (ED50).

Absolute threshold value

Threshold value

Absolute

The benchmark dose is defined as an absolute threshold value.

Absolute difference

Absolute difference

Difference

The benchmark dose is defined an absolute difference with the background risk.