Kinetic modules

Kinetic models convert exposures or hazard characterisations from one or more external routes or compartments to an internal (target) compartment. The reverse conversion from internal to external can alos be made (reverse dosimetry).

In a simple tier, kinetic models are specified as absorption factors. In a higher tier, PBK models of a specified type (currently avauliable is the Cosmos model) are linked to MCRA. Kinetic model instances for specific substances and test systems (e.g. cypermethrin in the rat) are specified with parameter sets for the chosen kinetic model.

• Kinetic models