Hazard characterisations settings¶

Calculation settings¶

Table 140 Calculation settings for module Hazard characterisations.¶
Name	Description
Risk type	The type of exposure considered in the assessment; acute (short term) or chronic (long-term).
Target level	Select to express hazard characterisations at external or internal exposure level.
Method	Choose method for computing the hazard characterisations: from in-vivo or in-vitro points of departure or both.
Expression type	Specifies how hazard characterisations are expressed: as BMD, as NOAEL, or the expression type is ignored.
Selection method in case of multiple candidate hazard characterisations	Choose either the most toxic (default) or an aggregated hazard characterisation when in nominal runs there are multiple available candidates. In uncertainty runs, multiple candidates are always resampled.
Impute missing hazard characterisations	If selected, missing hazard characterisations are imputed based on Munro NOELs or on other available points of departure.
Imputation method	Imputation of Hazard characterisations: use low percentile (P5) or unbiased central estimate from either the Munro set or the available POD collection.
Use BMDs from dose response models	If selected, preferably BMDs from dose response models will be used. Only if these are not available, other POD data are used.
Use inter-species conversions	If selected, inter-species conversion factors ill be used (default value, e.g. 10, or data).
Use intra-species factors	If selected, intra-species conversion factors will be used (default value, e.g. 10, or data).

Table 141 Output settings for module Hazard characterisations.¶
Name	Description
Lower percentage for variability (%)	The default value of 25% may be overruled.
Upper percentage for variability (%)	The default value of 75% may be overruled.

Table 142 Uncertainty settings for module Hazard characterisations.¶
Name	Description
Resample intra-species factor	Specifies whether intra-species factors are resampled from a parametric uncertainty distribution.
Resample hazard characterisations or RPFs	Specifies whether to resample the hazard characterisations or relative potency factors. Requires hazard characterisation or RPF uncertainty to be quantified in DoseResponseModelsUncertain or RelativePotencyFactorsUncertain tables.