Hazard characterisations

Introduction

The goal of this exercise is to try and find target hazard doses.

Preparation

If you haven’t done so, in the workspace browser (use the icon), create a new workspace named Examples, using the .

The data files used in the example(s) in this section, are located in the data folder Documentation-Examples / Exercise Hazard characterisations.

Example 1

In this example, Imazalil target dose from NOAEL will be calculated.

  • In the Examples workspace, create a new action (using )

    • Then select Show all action types, and select Hazard characterisations

    • Name it TargetDoseImazalil

    • Use as Hazard characterization settings

      • Risk type: Chronic

      • Target level: External

    • Press Create

  • Then go to the Actions settings of this action.

    • At Scope, click Substances (path: Hazard characterisations / Substances)

      • At Substances data source with browse to the file UserGroupDemo-TargetDosescalculation-Substances.xlsx and Select

      • At Substances selection with

        • Deselect everything, by clicking the on the first line, next to the word Code

        • Select only Imazalil, and Save

        • In the green navigation bar, click Hazard characterisations to go up one level.

    • At Scope, click Effects (path: Hazard characterisations / Effects)

      • At Effects data source with browse to the file EuroMix Effects and AOP Network Steatosis.xlsx and Select

      • At Effects selection with

        • Deselect everything by clicking on the first line, next to the word Code

        • On the second page, select only Steatosis-liver, and Save

      • At Effect Settings for focal effect select Steatosis-liver and press Save Changes.

      • In the green navigation bar, click Hazard characterisations to go up one level.

    • At Inputs, click Active substances (path: Hazard characterisations / Active substances)

      • At Inputs, click Points of departure (path: Hazard characterisations / Active substances / Points of departure)

        • At Points of departure data source with browse to the file UserGroupDemo-TargetDosesCalculation-HazardDoses.xlsx and Select

        • In the green navigation bar, click Active substances to go up one level

      • At Active substances click Compute

      • In the green navigation bar, click Hazard characterisations to go up one level.

    • At Hazard characterisations settings, for Expression type select NOAEL (convert all hazard characterisations as NOAELs), and press Save Changes

    • At Hazard characterisations settings, Select Use inter-species conversions

    • At Hazard characterisations settings, Select Use intra-species factors

  • Now run the model, by pressing the run icon in the green bar.

Try to find the following results:

  1. The NOAEL for Imazalil used as point of departure.

  2. The target hazard dose based on the default assessment factors 1/10 and 1/10 for inter-species and within-species conversion.

    • This is 40 µg/kg bw/day.