Exposure mixtures settings

Calculation settings

Table 120 Calculation settings for module Exposure mixtures.

Name	Type	Description
Sparseness parameter	Numeric	Sparseness parameter. Value between 0 (not sparse, many substances) and 1 (sparse, few substances).
Number of mixtures	Numeric	The number of mixtures.
Iterations	Numeric	Maximum number of iterations, e.g. 1000.
Seed for pseudo-random number generator.	Numeric	Random seed for initialising matrix W and H.
Substance weighting	ExposureApproachType	Risk based (exposures in equivalents of the reference substance) or standardised (standardised exposures per substance have variance 1).
Convergence criterion	Numeric	Convergence criterion for factorisation algorithm.
Cutoff MCR	Numeric	For selection of individual(day) exposures with maximum cumulative ratio (MCR = total exposure/maximum) above the cutoff.
Cutoff percentage in population ranked on total exposure	Numeric	For selection of individual(day) exposures above the cutoff percentage in the set of individual(day)s ranked on total exposure.
Target level	TargetLevelType	Select to express hazard characterisations at external or internal exposure level. For an aggregate assessement, that is dietary and nondietary exposure data are combined, the target dose level is always internal. When only dietary exposures are available, the target dose level is optional, i.c. external or internal.
Internal concentration	InternalConcentrationType	Internal concentrations are derived form dietary and/or non-dietary concentrations and aggregated using a kinetic or absorption factor model or are human monitoring concentrations.