Assessment group membership probabilities

Introduction

The goal of this exercise is to assess group membership probabilities.

Preparation

If you haven’t done so, in the workspace browser (use the icon), create a new workspace named Examples, using the .

The data files used in the example(s) in this section, are located in the data folder Documentation-Examples / Exercise Dietary Exposure Assessment.

Example 1

  • In the Examples workspace, create a new action (using )

    • Then select Dietary exposures

    • Name it Dietary exposures

    • Use as Dietary exposures settings

      • Tier: EFSA Guidance Optimistic

      • Risk type Chronic

      • Select Cumulative

    • Press Create

  • Then go to the actions settings of this action (path: Dietary exposures)

    • At Scope, click Foods (path: Dietary exposures / Foods)

      • At Foods data source with browse to the file UserGroupDemo-Foods.xlsx and Select

      • In the green navigation bar, click Dietary exposures to go up one level

    • At Scope, click Substances (path: Dietary exposures / Substances)

      • At Substances data source with browse to the file UserGroupDemo-Substances.xlsx and Select

      • At Substance settings for Index substance select Cyproconazole and press Save Changes

      • In the green navigation bar, click Dietary exposures to go up one level

    • At Scope, click Effects (path: Dietary exposures / Effects)

      • At Effects data source with browse to the file Effect - Steatosis.xlsx and Select

      • At Effect Settings for focal effect select Steatosis-liver and press Save Changes

      • In the green navigation bar, click Dietary exposures to go up one level.

    • At Inputs, click Consumptions by modelled food (path: Dietary exposures / Consumptions by modelled food)

      • At Inputs, click Consumptions (path: Dietary exposures / Consumptions by modelled food / Consumptions)

        • At Consumptions data source with browse to the file UserGroupDemo-Consumptions.xlsx and Select

        • At Consumption settings for Food survey select DNFCS_2003 and press Save Changes

        • In the green navigation bar, click Consumptions by modelled food to go up one level

      • At Inputs, click Food conversions (path: Dietary exposures / Consumptions by modelled food / Food conversions)

        • At Inputs, click Foods as measured (path: Dietary exposures / Consumptions by modelled food / Food conversions / Foods as measured)

          • At Inputs, click Concentrations (path: Dietary exposures / Consumptions by modelled food / Food conversions / Foods as measured / Concentrations)

            • At Concentrations data source with browse to the file UserGroupDemo-ConcentrationData.xlsx and Select

            • In the green navigation bar, click Food conversions to go up two levels

        • At Inputs, click Food recipes (path: Dietary exposures / Consumptions by modelled food / Food Food recipes)

          • At Food recipes data source, with browse to the file UserGroupDemo-FoodRecipes.xlsx

          • In the green navigation bar, click Dietary exposures to go up three levels

    • At Inputs, click Concentration models (path: Dietary exposures / Concentration models)

      • At Inputs, click Relative potency factors (path: Dietary exposures / Concentration models / Relative potency factors)

        • At Relative potency data source with browse to the file UserGroupDemo-RelativePotencyFactors.xlsx and Select

        • In the green navigation bar, click Dietary exposures to go up two levels

    • At Inputs, click Processing factors (path: Dietary exposures / Processing factors)

      • At Processing factors data source with browse to the file UserGroupDemo-ProcessingFactors.xlsx and Select

      • In the green navigation bar, click Dietary exposures to go up one level

    • At Inputs, click Active substances (optional) (path: Dietary exposures / Active substances)

      • At Inputs, click Points of departure (path: Dietary exposures / Active substances / Points of departure)

        • At Points of departure data source, with browse to the file HazardDoses - Triazoles.xlsx

        • In the green navigation bar, click Dietary exposures to go up two levels

  • Now run the model, by pressing the run icon in the grey bar.

Try to find the following results:

  1. Exposure percentiles daily intakes

  2. Substance with highest contribution to the total exposure distribution

  3. The food-as-measured with the highest contribution to the upper tail of the exposure distribution

Example 2

Repeat the run of the previous task, but instead of the nominal run, now do an uncertainty analysis loop.

  • Click on the icon (in the grey bar) to open the uncertainty settings panel, and check Perform uncertainty analysis

    • For Monte Carlo iterations per uncertainty run choose 100, and press Save Changes

  • Now run the model, by pressing the run icon in the grey bar.

Compare with the previous results, to find:

  1. Exposure percentiles daily intakes with uncertainty bounds

  2. Substance with highest contribution to the total exposure distribution

  3. The food-as-measured with the highest contribution to the upper tail of the exposure distribution