Risk steatosis from imazalil¶
This standard action is of type: Risks
In-vitro tests may help to reduce the use of test animals. What is the impact of this for risk assessment? Traditional risk assessment often uses animal data to evaluate toxicological limit values, such as the acceptable daily intake (ADI). In this standard action such a traditional risk calculation for the example of steatosis as health effect and imazalil as chemical substance can be compared to a similar calculation, but with the toxicological hazard characterisation based on in-vitro data from AdipoRed measurements in human liver cells. In-vitro concentrations are assumed to represent internal liver concentrations and a human physiologically based kinetic model for imazalil is used to extrapolate from in-vitro to in-vivo doses.
In this standard action, risk for steatosis from exposure to imazalil is estimated from in-vivo or in-vitro based hazard characterisations.
- Two parameter sets are available:
estimates based on QSAR models only, and
estimates based on QSAR models and in-vitro experiments.
The latter parameter set shows that in the long term concentration levels of imazalil in the liver are stationary.
| Table Group | Name | Repository | Type |
|---|---|---|---|
AdverseOutcomePathwayNetworks |
AOPN-Effects-EffectRelations-181017.xlsx |
Standard Actions/Risk steatosis from imazalil |
Fixed |
Effects |
AOPN-Effects-EffectRelations-181017.xlsx |
Standard Actions/Risk steatosis from imazalil |
Fixed |
DoseResponseData |
BfR-HepaRG-AdipoRed-Single.xlsx |
Standard Actions/Risk steatosis from imazalil |
Fixed |
Concentrations |
ConcentrationsSSD_20190129.zip |
Standard Actions/Risk steatosis from imazalil |
Fixed |
Compounds |
EuroMix Substances Inventory (v8) (PPPs).zip |
Standard Actions/Risk steatosis from imazalil |
Fixed |
KineticModels |
EuroMix-KineticModels-CosmosV6 9 substances ParA QSAR.xlsx |
Standard Actions/Risk steatosis from imazalil |
Variable |
KineticModels |
EuroMix-KineticModels-CosmosV6 9 substances ParB QSAR-Invitro.xlsx |
Standard Actions/Risk steatosis from imazalil |
Variable |
UnitVariability |
Foods coded in FoodEx1.mdb |
Standard Actions/Risk steatosis from imazalil |
Fixed |
HazardCharacterisations |
HazardCharacterisation Imazalil.xlsx |
Standard Actions/Risk steatosis from imazalil |
Fixed |
Survey |
NL-VCP-RPC 2007-2010 7-69yr.mdb |
Standard Actions/Risk steatosis from imazalil |
Fixed |
FoodTranslations |
NL-VCP-RPC Foods.mdb |
Standard Actions/Risk steatosis from imazalil |
Fixed |
Foods |
NL-VCP-RPC Foods.mdb |
Standard Actions/Risk steatosis from imazalil |
Fixed |
EffectRepresentations |
TestSystems-Responses-EffectRepresentations-181026.xlsx |
Standard Actions/Risk steatosis from imazalil |
Fixed |
Responses |
TestSystems-Responses-EffectRepresentations-181026.xlsx |
Standard Actions/Risk steatosis from imazalil |
Fixed |
TestSystems |
TestSystems-Responses-EffectRepresentations-181026.xlsx |
Standard Actions/Risk steatosis from imazalil |
Fixed |