MCRA Documentation
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Contents

  • About the toolbox
    • Data and calculation model
      • Modular design
      • Nominal run and uncertainty analysis
      • Retain & Refine and tiered approaches
      • Uncertainty
        • Uncertainty due to limited sampled data
          • Empirical method, resampling
          • Parametric methods
        • Uncertainty due to missing data
        • Uncertainty due to modelling approach
    • Data repository
      • Repository access levels
      • Linking remote data repositories
    • Workspaces and actions
      • Workspace browser
      • Workspace overview page
      • Action page
        • Scoping: entity selection
          • Implicit versus explicit scoping
          • Comparing new data to set scopes
  • Modules
    • Primary entity modules
      • Effects
        • Effects data formats
          • Effects
        • Effects calculation
        • Effects settings
          • Selection settings
      • Foods
        • Foods data formats
          • Foods
        • Food coding systems
          • Food classification: FoodEx1
            • Food code definition
            • Food codes in consumption surveys
            • Food codes in concentration data
            • Food processing
            • Recipes and food translation
            • Market shares and brand loyalty
            • Supertypes
            • Maximum Residue Levels
            • MCRA food code conversion algorithm
          • Food classification: FoodEx2
            • Foods and food hierarchies
            • Facets and facet descriptors
            • Implicit facets
            • Foods as facets
            • The FoodEx 2 coding system
        • FoodEx2
          • Reading and dealing with FoodEx 2 codes
          • Reading and dealing with facets data
            • Reading facets data
            • Dealing with facets
            • Facets in food conversion
            • Using facets that reveal processing data
        • Food hierarchies
          • Reading and dealing with food hierarchy data
          • Reading food hierarchy data
          • Using food hierarchies for food conversion
          • Using hierarchy data in the output
        • Food unit weights
      • Populations
        • Populations data formats
          • Populations
        • Populations settings
          • Selection settings
      • Responses
        • Responses data formats
          • Responses
        • Responses settings
          • Selection settings
      • Substances
        • Substances data formats
          • Substances
        • Substances settings
          • Selection settings
      • Test systems
        • Test systems data formats
          • Test Systems
    • Consumption modules
      • Consumptions
        • Consumptions data formats
          • Consumptions
        • Consumptions settings
          • Selection settings
          • Uncertainty settings
        • Consumptions uncertainty
      • Food recipes
        • Food recipes data formats
          • Food recipes
      • Market shares
        • Market shares data formats
          • MarketShares
        • Market shares and brand loyalty
      • Single value consumptions
        • Single value consumptions data formats
          • Single value consumptions
        • Single value consumptions calculation
        • Single value consumptions settings
          • Calculation settings
    • Occurrence modules
      • Concentration distributions
        • Concentration distributions data formats
          • Concentration distributions
      • Concentration limits
        • Concentration limits data formats
          • Concentration limits
      • Concentration models
        • Concentration models calculation
          • Concentration model types
            • Empirical model
            • Non-detect spike lognormal model
            • Non-Detect-Spike Truncated lognormal model
            • Censored Lognormal model
            • Zero-spike censored lognormal model
            • Non-detect spike MRL model
            • Summary statistics model
          • Concentration models
            • Mixture zero spike and censored lognormal
            • Censored lognormal
            • Mixture non-detect spike and truncated lognormal
            • Mixture non-detect spike and lognormal
          • Imputation
            • No imputation
            • Impute all nondetects
            • Impute nondetects based on authorized uses
            • No imputation except for authorized uses
          • Deriving the variance of TDS samples from monitoring
        • Concentration models settings
          • Calculation settings
          • Uncertainty settings
        • Concentration models tiers
          • Overview
          • EFSA 2012 Optimistic
          • EFSA 2012 Pessimistic - Acute
          • EFSA 2012 Pessimistic - Chronic
          • EC 2018 Tier 1
          • EC 2018 Tier 2
          • EFSA 2012 Pessimistic
        • Concentration models uncertainty
      • Concentrations
        • Concentrations data formats
          • Concentration data
        • Concentrations calculation
          • Filter samples exceeding the concentration limits
          • Substance conversion
            • Use of substance authorisations in substance conversion
          • Food extrapolation
            • 1. Substance-specific imputation of missing values by extrapolated measurements
            • 2. Extrapolation of complete samples for multiple substances
          • Water imputation
          • Focal commodity scenario analysis
            • Replace samples with focal commodity samples
            • Append focal commodity samples
            • Replace measurements of focal food/substance combinations
            • Remove measurements of focal food/substance combinations
          • Filter samples exceeding the concentration limits
          • Filter samples by specific sample properties
        • Concentrations settings
          • Selection settings
          • Uncertainty settings
        • Concentrations tiers
          • Overview
          • EC 2018 Tier 1
          • EC 2018 Tier 2
        • Concentrations uncertainty
      • Deterministic substance conversion factors
        • Deterministic substance conversion factors data formats
          • Deterministic substance conversion factors
      • Focal food concentrations
        • Focal food concentrations data formats
        • Focal food concentrations settings
          • Selection settings
          • Calculation settings
      • Food extrapolations
        • Food extrapolations data formats
          • Food extrapolation rules
      • Modelled foods
        • Modelled foods calculation
        • Modelled foods settings
          • Calculation settings
      • Occurrence frequencies
        • Occurrence frequencies data formats
          • Occurrence frequencies
        • Occurrence frequencies calculation
        • Occurrence frequencies Settings
          • Selection settings
      • Occurrence patterns
        • Occurrence patterns data formats
          • Agricultural uses
        • Occurrence patterns calculation
        • Occurrence patterns settings
          • Selection settings
          • Uncertainty settings
        • Occurrence patterns tiers
          • Overview
          • EC 2018 Tier 1
          • EC 2018 Tier 2
      • Processing factors
        • Processing factors data formats
          • Processing factors
        • Processing factors calculation
          • Processing factors fixed or distribution based
            • Nonnegative processing factors
            • Processing factors between 0 and 1
        • Processing factors settings
          • Uncertainty settings
        • Processing factors uncertainty
      • Single value concentrations
        • Single value concentrations data formats
          • Single value concentration data
        • Single value concentrations calculation
        • Single value concentrations settings
          • Selection settings
      • Substance authorisations
        • Substance authorisations data formats
          • Substance authorisations
      • Substance conversions
        • Substance conversions data formats
          • Substance conversion rules
      • Total diet study sample compositions
        • Total diet study sample compositions data formats
          • Total diet study data
      • Unit variability factors
        • Unit variability factors data formats
          • Unit variability factors
    • Exposure modules
      • Consumptions by modelled food
        • Consumptions by modelled food calculation
        • Consumptions by modelled food
          • Calculation settings
      • Dietary exposures
        • Dietary exposures calculation
          • Acute exposure assessment
            • Modelling unit-to-unit variation
              • Estimation of intake values using the concept of unit variability
              • Beta distribution
              • Lognormal distribution
              • Bernoulli distribution
          • Chronic exposure assessment
            • Chronic exposure models
              • Observed individual means (OIM)
              • Model based and model assisted
              • Betabinomial-Normal model (BBN)
              • Logisticnormal-Normal model (LNN with and without correlation)
              • Discrete/semi-parametric model (ISUF)
                • Model-Then-Add
                • Chronic exposure as a function of covariates
                • Total Diet Study
            • Model-Then-Add
              • The Model step
              • The Add step
            • Chronic exposure as a function of covariates
            • Total Diet Study
              • TDS reduction to limit scenario analysis
          • Substance concentrations generation
            • Sample-based concentrations generation
            • Substance-based concentrations generation
          • Processing correction
          • Chronic exposure assessment, daily consumed foods
            • Model based usual intake
            • Model based usual intake on the transformed scale
            • Model based using a logarithmic transformation
            • Model based using a power transformation
            • Model assisted usual intake on the transformed scale
            • Model assisted using a logarithmic transformation
            • Model assisted using a power transformation
          • Chronic exposure assessment, episodically consumed foods
            • Beta-Binomial model for frequencies (BBN)
            • Model based frequencies for usual intake
            • Model assisted frequencies for usual intake
            • Logistic-Normal model for frequencies (LNN0)
            • Model based frequencies for usual intake
            • Model assisted frequencies for usual intake
            • Logistic-Normal model for frequencies correlated with amounts (LNN)
            • Model based usual intake
            • Model assisted usual intake
        • Dietary exposures settings
          • Calculation settings
          • Output settings
          • Uncertainty settings
        • Dietary exposures tiers
          • Overview
          • EFSA 2012 Optimistic
          • EFSA 2012 Pessimistic - Acute
          • EFSA 2012 Pessimistic - Chronic
          • EC 2018 Tier 1
          • EC 2018 Tier 2
          • EFSA 2012 Pessimistic
      • High exposure food substance combinations
        • High exposure food substance combinations calculation
          • Screening calculation for large Cumulative Assessment Groups
            • Statistical model for the screening step (acute exposure)
            • Statistical model for the screening step (chronic exposure)
        • High exposure food substance combinations settings
          • Calculation settings
      • Exposures
        • Exposures calculation
          • Combining dietary and non-dietary exposures
            • Example 1
            • Example 2
            • Example 3
          • Internal exposures calculation
            • Calculation of internal concentrations using absorption factors
            • Calculation of internal concentrations using kinetic models
              • Dosing patterns
              • Non-stationary period
          • Counting of co-exposure
          • Maximum Cumulative Ratio
        • Exposures settings
          • Calculation settings
          • Output settings
          • Uncertainty settings
      • Exposure mixtures
        • Exposure mixtures calculation
          • Sparse nonnegative matrix underapproximation
            • Exposure matrix
            • Mechanisms to influence sparsity
        • Exposure mixtures settings
          • Calculation settings
      • Food conversions
        • Food conversions calculation
        • Food conversion settings
          • Calculation settings
      • Human monitoring analysis
        • Human monitoring analysis calculation
          • Imputation of non-detects
          • Imputation of missing values
          • Calculation of acute human monitoring concentrations
          • Calculation of chronic human monitoring concentrations
          • Compare measured and modelled exposures
        • Human monitoring analysis settings
          • Calculation settings
      • Human monitoring data
        • Human monitoring data data formats
          • Human monitoring samples
        • Human monitoring data settings
          • Selection settings
      • Non-dietary exposures
        • Non-dietary exposures data formats
          • Non-dietary exposures
        • Non-dietary exposures settings
          • Uncertainty settings
        • Non-dietary exposures uncertainty
      • Single value dietary exposures
        • Single value dietary exposures data formats
          • Dietary exposures
        • Single value dietary exposures calculation
          • Acute single value dietary exposure assessment
            • IESTI (International Estimated Short-Term Intake)
            • Alternative IESTI-styled assessments
            • IESTI special cases
          • Chronic single value dietary exposure assessment
            • TMDI (Theoretical Maximum Dietary Intake)
            • IEDI (International Estimated Dietary Intake)
            • NEDI (National Estimated Dietary Intake): Rees-Day model (I)
            • NEDI (National Estimated Dietary Intake): Rees-Day model (II)
            • Alternative TMDI-, IEDI- or NEDI-styled assessments
        • Single value dietary exposures settings
          • Selection settings
          • Calculation settings
    • Hazard modules
      • Active substances
        • Active substances data formats
          • Assessment group membership models
        • Active substances calculation
        • Active substances settings
          • Calculation settings
          • Uncertainty settings
      • AOP networks
        • AOP networks data formats
          • AOP networks
        • AOP networks settings
          • Selection settings
      • Dose response data
        • Dose response data data formats
          • Dose response data
        • Dose response data settings
          • Selection settings
      • Dose response models
        • Dose response models data formats
          • Dose response models
        • Dose response models calculation
      • Effect representations
        • Effect representations data formats
          • Effect representations
        • Effect representations data formats
          • Effect representations
      • Hazard characterisations
        • Hazard characterisations data formats
          • Hazard characterisations
        • Hazard characterisations calculation
          • Hazard characterisation type extrapolation
          • Inter-species extrapolation
          • Intra-species extrapolation of hazard characterisations
          • Additional assessment factors
          • In-vitro in-vivo extrapolation (IVIVE)
            • IVIVE for calculating internal hazard characterisations
            • IVIVE for calculating external hazard characterisations
          • Kinetic conversion of hazard characterisations
            • Extrapolation from external to internal hazard characterisations
              • Calculation of internal doses using absorption factors
              • Calculation of internal doses using human PBPK models
              • Calculation of internal doses using animal PBPK models
            • Extrapolation from internal to external hazard characterisations
          • Hazard characterisation imputation
            • Munro P5 (TTC approach)
            • Munro central value
            • Available hazard characterisations distribution P5
            • Available hazard characterisations distribution central value
          • Aggregation over multiple available hazard characterisations
        • Hazard characterisations settings
          • Selection settings
          • Calculation settings
          • Uncertainty settings
      • Inter-species conversions
        • Inter-species conversions data formats
          • Inter-species conversions
        • Inter-species conversions settings
          • Selection settings
          • Uncertainty settings
      • Intra species factors
        • Intra-species factors data formats
          • Intra-species factors
        • Intra species factors settings
          • Selection settings
      • Points of departure
        • Points of departure data formats
          • Points of departure
        • Points of departure settings
          • Uncertainty settings
      • Relative potency factors
        • Relative potency factors data formats
          • Relative potency factors
        • Relative potency factors calculation
        • Relative potency factors settings
          • Calculation settings
          • Uncertainty settings
    • In-silico modules
      • Molecular docking models
        • Molecular docking models data formats
          • Molecular docking models
      • QSAR membership models
        • QSAR membership models data formats
          • QSAR membership models
    • Kinetic modules
      • Kinetic models
        • Kinetic models data formats
          • Kinetic models
        • Kinetic models settings
          • Calculation settings
          • Uncertainty settings
        • Available kinetic models
          • EuroMix Generic PBTK model v6
          • EuroMix Generic PBTK model v5
          • Generic Model BPA
          • EuroMix generic PBTK model
          • Bisphenol model
    • Risk modules
      • Risks
        • Risks calculation
          • Individual risks
        • Risks settings
          • Calculation settings
          • Output settings
      • Single value risks
        • Single value risks calculation
          • Combining single value exposures and hazard characterisations
          • Single value risks from individual risks
            • Adjustment factors and uncertainty specification
            • Background-only adjustment factor
        • Single value risks settings
          • Calculation settings
  • Standard actions
    • Chronic cumulative exposure assessment PFAS
    • Chronic cumulative exposure assessment PA
    • Demo acute cumulative risk assessment
    • EU acute cumulative exposure assessment (2018) Tier I and Tier II
    • EU chronic cumulative exposure assessment (2018) Tier I and Tier II
    • Training prospective risk assessment acute Tier II
    • Training prospective risk assessment chronic Tier II
    • Training substance prioritisation acute neuro
    • IPGF Acute Cumulative Risk Assessment No Background
  • Examples
    • Cumulative dietary exposure assessment
      • Introduction
      • Preparation
      • Example 1
      • Example 2
      • Example 3
    • Aggregate exposure assessment
      • Introduction
      • Preparation
      • Example 1
      • Example 2
    • Hazard characterisations from PoDs
      • Introduction
      • Preparation
      • Example 1
    • Health impact estimates
      • Introduction
      • Preparation
      • Example 1
    • Assessment group membership probabilities
      • Introduction
      • Preparation
      • Example 1
      • Example 2
  • Publications using MCRA
  • References
  • List of Symbols
  • Appendices
    • Api Documentation
    • Munro collection
    • Unit definitions
      • Benchmark response types
      • Body weight units
      • Concentration units
      • Concentration value types
      • Consumption intake units
      • Consumption units
      • Consumption value types
      • Dose response model types
      • Dose units
      • Exposure route types
      • Exposure types
      • Exposure units
      • Harvest application types
      • Hazard characterisation types
      • Point of departure types
      • Response types
      • Target dose level types
      • Test system types
    • Transformations
      • Box Cox power transformation
    • Gauss-Hermite
      • Gauss-Hermite integration
      • One-dimensional Gauss-Hermite integration
      • Two-dimensional Gauss-Hermite integration
      • Maximum likelihood for the LNN model with two-dimensional Gauss-Hermite integration
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