Hazard characterisations from PoDs

Introduction

The goal of this exercise is to try to establish hazard characterisations from PoDs (NOAELs).

Preparation

If you haven’t done so, in the workspace browser (use the icon), create a new workspace named Examples, using the .

The data files used in the example(s) in this section, are located in the data folder Documentation-Examples / Exercise Hazard characterisations.

Example 1

In this example, Imazalil target dose from NOAEL will be calculated.

  • In the Examples workspace, create a new action (using )

    • Then select Show all action types, and select Hazard characterisations

    • Name it TargetDoseImazalil

    • Use as Hazard characterization settings

      • Risk type: Chronic

      • Target level: External

    • Press Create

  • Then go to the Actions settings of this action.

    • At Scope, click Effects (path: Hazard characterisations / Effects)

      • At Effects data source with browse to the file Effects and AOP Network Steatosis.xlsx and Select

      • At Effects selection with

        • Deselect everything by clicking on the first line, next to the word Code

        • On the second page, select only Steatosis-liver, and Save

      • At Effect Settings for focal effect select Steatosis-liver and press Save Changes.

      • In the green navigation bar, click Hazard characterisations to go up one level

    • At Scope, click Substances (path: Hazard characterisations / Substances)

      • At Substances data source with browse to the file TargetDosescalculation-Substances.xlsx and Select

      • At Substances selection with

        • Deselect everything, by clicking the on the first line, next to the word Code

        • Select only Imazalil, and Save

        • In the green navigation bar, click Hazard characterisations to go up one level

    • At Inputs, click Points of departure (path: Hazard characterisations / Points of departure)

      • At Points of departure data source with browse to the file TargetDosesCalculation-HazardDoses.xlsx and Select

      • In the green navigation bar, click Hazard characterisations to go up one level

    • At Hazard characterisations settings, for Expression type select NOAEL (convert all hazard characterisations as NOAELs)

    • At Hazard characterisations settings, Select Use inter-species conversions

    • At Hazard characterisations settings, Select Use intra-species factors, and press Save Changes

  • Now run the model, by pressing the run icon in the grey bar.

Try to find the following results:

  1. The NOAEL for Imazalil used as point of departure.

  2. The target hazard dose based on the default assessment factors 1/10 and 1/10 for inter-species and within-species conversion.

Answers:

  • In the grey bar, browse to the results panel by clicking the icon and click on the latest output (path: Results / TargetDoseImazalil)

    • In the Hazard characterisations tab, browse in the tree (unfold by clicking where necessary) to Available hazard characterisations

      • The NOAEL for Imazalil is 40 µg/kg bw/day.