Additional assessment factors

An additional assessment factor is used for extrapolation from the POD to the hazard characterisation in humans for sources where appropriate data or information is scarce or missing. This factor can be used as a worst case value (preferably AF = 100) for inter- and intra-species extrapolation, but it may equally well serve as an additional extrapolation factor next to inter- and/or intra-species extrapolation. Then, the additional assessment factor serves merely as factor that accounts for difference in e.g. route to route, metabolic rates in interspecies, completeness and consistency of available data, reliability of alternative data (e.g. read-across) or quality of data in general.