Unit definitions

Benchmark response types

Accepted benchmark response types.

Table 183 Unit definition for Benchmark response types.
Name Short name Aliases Description

Fraction change

Fraction change

FractionChange, FactorChange

The benchmark response is defined as a fraction change of the background response (i.e., defined for both increase and decrease). E.g., for a factor of 0.1, the benchmark response is at +/- 10% of background response.

Percentage change

Percentage change

PercentageChange

The benchmark response is defined as a percentage change of the background response (i.e., defined for both increase and decrease). E.g., for a percentage of 10, the benchmark response is at +/- 10% of background response.

Fraction of background response

Fraction of background

Factor, FactorOfBackground

The benchmark response is defined as a fraction of the background response. E.g., for a factor of 0.9, the benchmark response is at 0.9 times the background response (i.e., a decrease).

Percentage of background response

Percentage of background

Percentage, PercentageOfBackground

The benchmark response is defined as a percentage of the background response. E.g., for a percentage of 90, the benchmark response is at 90% of the background response (i.e., a decrease).

Extra risk

ER

ExtraRisk

For quantal response types. The benchmark dose is defined as the dose that corresponding with an extra risk of a factor times the background risk. A factor of 0.05 corresponds with 5% extra risk.

Additional risk

AR

AdditionalRisk

For quantal response types. The benchmark dose is defined as the dose that corresponding with an additional risk of a factor times the background risk. A factor of 0.05 corresponds with 5% additional risk.

ED50

ED50

ED50

For quantal response types. The benchmark dose is defined as the dose that corresponds with an estimated risk of 50% (ED50).

Absolute threshold value

Threshold value

Absolute

The benchmark dose is defined as an absolute threshold value.

Absolute difference

Absolute difference

Difference

The benchmark dose is defined an absolute difference with the background risk.

Body weight units

Units for describing person body weights.

Table 184 Unit definition for Body weight units.
Name Short name Aliases

Kilogram

kg

kg, kilograms, kilogr, 3, G167A

Gram

g

g, grams, gr, 0, G148A

Concentration units

Units for describing substance concentrations.

Table 185 Unit definition for Concentration units.
Name Short name Aliases

kilogram/kilogram

kg/kg

kg/kg, kilogram/kilogram, kilogram/kg, 0, G063A

gram/kilogram

g/kg

g/kg, gram/kilogram, gram/kg, gr/kg, -3, G015A, G060A, G191A

milligram/kilogram

mg/kg

mg/kg, milligram/kilogram, milligram/kg, milligr/kg, -6, G049A, G061A

microgram/kilogram

µg/kg

µg/kg, ug/kg, microgram/kilogram, microgram/kg, microgr/kg, -9, G050A, G076A

nanogram/kilogram

ng/kg

ng/kg, nanogram/kilogram, nanogram/kg, nanogr/kg, -12, G077A, G080A

picogram/kilogram

pg/kg

pg/kg, picogram/kilogram, picogram/kg, picogr/kg, -15, G081A

kilogram/liter

kg/L

kg/l, kg/L, kilogram/liter, kilogram/litre, G017A

gram/liter

g/L

g/l, g/L, gram/liter, gram/litre, gr/l, gr/L, G016A

milligram/liter

mg/L

mg/l, mg/L, milligram/liter, milligram/litre, milligr/l, milligr/L, G052A, G062A

microgram/liter

µg/L

µg/l, ug/L, microgram/liter, microgram/litre, microgr/l, microgr/L, G051A, G079A

nanogram/liter

ng/L

ng/l, ng/L, nanogram/liter, nanogram/litre, nanogr/l, nanogr/L, G078A

picogram/liter

pg/L

pg/l, pg/L, picogram/liter, picogram/litre, picogr/l, picogr/L

microgram/milliliter

µg/mL

µg/ml, ug/mL, microgram/milliliter, microgram/millilitre, microgr/ml, microgr/mL

nanogram/milliliter

ng/mL

ng/ml, ng/mL, nanogram/milliliter, nanogram/millilitre, nanogr/ml, nanogr/mL

Consumption units

Units for consumption amounts.

Table 186 Unit definition for Consumption units.
Name Short name Aliases

kilogram

kg

kg, kilograms, kilogr, 3, G167A

Gram

g

g, grams, gr, 0, G148A

Dose response model types

Known dose response model types.

Table 187 Unit definition for Dose response model types.
Name Short name Aliases Description

Exp-m1

Exp-m1

Expm1

Exp-m2

Exp-m2

Expm2

Exp-m3

Exp-m3

Expm3

Exp-m4

Exp-m4

Expm4

Exp-m5

Exp-m5

Expm5

Hill-m1

Hill-m1

Hillm1

Hill-m2

Hill-m2

Hillm2

Hill-m3

Hill-m3

Hillm3

Hill-m4

Hill-m4

Hillm4

Hill-m5

Hill-m5

Hillm5

TwoStage

TwoStage

TwoStage

LogLogist

LogLogist

LogLogist

Weibull

Weibull

Weibull

LogProb

LogProb

LogProb

Gamma

Gamma

Gamma

Logistic

Logistic

Logistic

Probit

Probit

Probit

LVM Exp m2

LVM Exp m2

LVM Exp m2

LVM Exp m3

LVM Exp m3

LVM_Exp_M3

LVM Exp m4

LVM Exp m4

LVM_Exp_M4

LVM Exp m5

LVM Exp m5

LVM_Exp_M5

LVM Hill m2

LVM Hill m2

LVM Hill m2

LVM Hill m3

LVM Hill m3

LVM_Hill_M3

LVM Hill m4

LVM Hill m4

LVM_Hill_M4

LVM Hill m5

LVM Hill m5

LVM Hill m5

Dose units

Units for describing substance doses.

Table 188 Unit definition for Dose units.
Name Short name Aliases

gram/kilogram bodyweight/day

g/kg bw/day

g/kg bw/day, gram/kg bw/day, gr/kg bw/day

milligram/kilogram bodyweight/day

mg/kg bw/day

mg/kg bw/day, milligram/kg bw/day, milligr/kg bw/day, G211A

microgram/kilogram bodyweight/day

µg/kg bw/day

µg/kg bw/day, microgram/kg bw/day, microgr/kg bw/day

nanogram/kilogram bodyweight/day

ng/kg bw/day

ng/kg bw/day, nanogram/kg bw/day, nanogr/kg bw/day

picogram/kilogram bodyweight/day

pg/kg bw/day

pg/kg bw/day, picogram/kg bw/day, picogr/kg bw/day

femtogram/kilogram bodyweight/day

fg/kg bw/day

fg/kg bw/day, femtogram/kg bw/day, femtogr/kg bw/day

gram/gram bodyweight/day

g/g bw/day

g/g bw/day, gram/g bw/day, gr/g bw/day

milligram/gram bodyweight/day

mg/g bw/day

mg/g bw/day, milligram/g bw/day, milligr/g bw/day

microgram/gram bodyweight/day

µg/g bw/day

µg/g bw/day, microgram/g bw/day, microgr/g bw/day

nanogram/gram bodyweight/day

ng/g bw/day

ng/g bw/day, nanogram/g bw/day, nanogr/g bw/day

picogram/gram bodyweight/day

pg/g bw/day

pg/g bw/day, picogram/g bw/day, picogr/g bw/day

femtogram/gram bodyweight/day

fg/g bw/day

fg/g bw/day, femtogram/g bw/day, femtogr/g bw/day

kilogram/day

kg/day

kg/day, kilogram/day, kilogr/day

gram/day

g/day

g/day, gram/day, gr/day

milligram/day

mg/day

mg/day, milligram/day, milligr/day

microgram/day

µg/day

µg/day, microgram/day, microgr/day

nanogram/day

ng/day

ng/day, nanogram/day, nanogr/day

picogram/day

pg/day

pg/day, picogram/day, picogr/day

femtogram/day

fg/day

fg/day, femtogram/day, femtogr/day

kilogram/kilogram

kg/kg

kg/kg, kilogram/kilogram, kilogram/kg, kg/kg bw

gram/kilogram

g/kg

g/kg, gram/kilogram, gram/kg, gr/kg, g/kg bw

milligram/kilogram

mg/kg

mg/kg, milligram/kilogram, milligram/kg, milligr/kg, mg/kg bw, G225A

microgram/kilogram

µg/kg

µg/kg, microgram/kilogram, microgram/kg, microgr/kg, µg/kg bw

nanogram/kilogram

ng/kg

ng/kg, nanogram/kilogram, nanogram/kg, nanogr/kg, ng/kg bw

picogram/kilogram

pg/kg

pg/kg, picogram/kilogram, picogram/kg, picogr/kg, pg/kg bw

Molar

M

M, mol/L

millimolar

mM

mM, mmol/L

micromolar

µM

uM, µM, umol/L

nanomolar

nM

nM, nmol/L

moles

moles

moles, Moles

millimoles

mmoles

mmoles, mMoles

micromoles

µmoles

umoles, uMoles

nanomoles

nmoles

nmoles, nMoles

Exposure route types

The different routes in which an individual is exposed to substance concentrations.

Table 189 Unit definition for Exposure route types.
Name Short name Aliases Description

Dietary exposure

Dietary

Dietary

Dietary exposure.

Non-dietary oral exposure

Oral

Oral

Non-dietary oral exposure.

Non-dietary dermal exposure

Dermal

Dermal

Non-dietary dermal exposure.

Non-dietary inhalation exposure

Inhalation

Inhalation

Non-dietary inhalation exposure.

At target

At target

AtTarget

Exposures directly at the target (organ).

Exposure types

The different types of exposure. I.e., acute or chronic.

Table 190 Unit definition for Exposure types.
Name Short name Aliases Description

Acute

Acute

Acute

Acute exposure.

Chronic

Chronic

Chronic

Chronic exposure.

Exposure units

Units for describing substance exposures.

Table 191 Unit definition for Exposure units.
Name Short name Aliases

gram/kilogram bodyweight/day

g/kg bw/day

g/kg bw/day, gram/kg bw/day, gr/kg bw/day, G212A

milligram/kilogram bodyweight/day

mg/kg bw/day

mg/kg bw/day, milligram/kg bw/day, milligr/kg bw/day, G211A

microgram/kilogram bodyweight/day

µg/kg bw/day

µg/kg bw/day, microgram/kg bw/day, microgr/kg bw/day, G210A

nanogram/kilogram bodyweight/day

ng/kg bw/day

ng/kg bw/day, nanogram/kg bw/day, nanogr/kg bw/day, G214A

picogram/kilogram bodyweight/day

pg/kg bw/day

pg/kg bw/day, picogram/kg bw/day, picogr/kg bw/day

femtogram/kilogram bodyweight/day

fg/kg bw/day

fg/kg bw/day, femtogram/kg bw/day, femtogr/kg bw/day

gram/gram bodyweight/day

g/g bw/day

g/g bw/day, gram/g bw/day, gr/g bw/day

milligram/gram bodyweight/day

mg/g bw/day

mg/g bw/day, milligram/g bw/day, milligr/g bw/day

microgram/gram bodyweight/day

µg/g bw/day

µg/g bw/day, microgram/g bw/day, microgr/g bw/day

nanogram/gram bodyweight/day

ng/g bw/day

ng/g bw/day, nanogram/g bw/day, nanogr/g bw/day

picogram/gram bodyweight/day

pg/g bw/day

pg/g bw/day, picogram/g bw/day, picogr/g bw/day

femtogram/gram bodyweight/day

fg/g bw/day

fg/g bw/day, femtogram/g bw/day, femtogr/g bw/day

kilogram/day

kg/day

kg/day, kilogram/day, kilogr/day

gram/day

g/day

g/day, gram/day, gr/day

milligram/day

mg/day

mg/day, milligram/day, milligr/day

microgram/day

µg/day

µg/day, microgram/day, microgr/day

nanogram/day

ng/day

ng/day, nanogram/day, nanogr/day

picogram/day

pg/day

pg/day, picogram/day, picogr/day

femtogram/day

fg/day

fg/day, femtogram/day, femtogr/day

gram/kilogram

g/kg

g/kg, gram/kg, gr/kg, G015A

milligram/kilogram

mg/kg

mg/kg, milligram/kg, milligr/kg, G061A

microgram/kilogram

µg/kg

µg/kg, microgram/kg, microgr/kg, G050A

nanogram/kilogram

ng/kg

ng/kg, nanogram/kg, nanogr/kg, G077A

picogram/kilogram

pg/kg

pg/kg, picogram/kg, picogr/kg, G081A

femtogram/kilogram

fg/kg

fg/kg, femtogram/kg, femtogr/kg

gram

g

g, gram, gr, G148A

milligram

mg

mg, milligram, milligr, G155A

microgram

µg

µg, microgram, microgr

nanogram

ng

ng, nanogram, nanogr, G120A

picogram

pg

pg, picogram, picogr, G125A

femtogram

fg

fg, femtogram, femtogr

Hazard characterisation types

Known hazard characterisation types.

Table 192 Unit definition for Hazard characterisation types.
Name Short name Aliases

Benchmark dose

BMD

BMD

No observed adverse effect level

NOAEL

NOAEL

Lowest observed adverse effect level

LOAEL

LOAEL

Acceptable daily intake

ADI

ADI

Acute reference dose

ARfD

ARfD

No observed effect level

NOEL

NOEL

Point of departure types

Known point of departure types.

Table 193 Unit definition for Point of departure types.
Name Short name Aliases Description

Benchmark dose

BMD

BMD

No observed adverse effect level

NOAEL

NOAEL

Lowest observed adverse effect level

LOAEL

LOAEL

No observed effect level

NOEL

NOEL

LD50

LD50

LD50

Median lethal dose.

Response types

Available response types.

Table 194 Unit definition for Response types.
Name Short name Aliases Description

Continuous multiplicative

CM

ContinuousMultiplicative

Response values are positive real numbers, e.g., weight, size.

Continuous additive

CA

ContinuousAdditive

Response values are real numbers, e.g., weight change, temperature.

Binary

B

Binary

Response values have binary outcomes (yes/no, true/false, success/failure, 0/1, etc.).

Quantal

Q

Quantal, Binomial

Response is measured in terms of number of successes out of N possible.

Quantal group

QG

QuantalGroup

Individual responses are measured as binary values, which may be grouped to form a quantal response.

Count

C

Count

Number of items (cells, molecules, deaths, etc.) in given interval/area/volume.

Ordinal

O

Ordinal

Relative scores (or graded scores) useable only for ranking.

Target dose level types

This unit specifies whether a dose is assumed to be an internal or external dose.

Table 195 Unit definition for Target dose level types.
Name Short name Aliases Description

External

Ext

External, Ext

External exposure.

Internal

Int

Internal, Int

Internal exposure.

Test system types

Available test system types.

Table 196 Unit definition for Test system types.
Name Short name Aliases Description

In vivo

In vivo

InVivo

In vivo

Cell line

Cell line

CellLine

CellLine

Primary cells

Primary cells

PrimaryCells

PrimaryCells

Tissue

Tissue

Tissue

Tissue

Organ

Organ

Organ

Organ