PBK model parametrisations settings

Calculation settings

Table 440 Calculation settings for module PBK model parametrisations.

Name	Type	Description
Multiple substances analysis	Boolean	Specifies whether the assessment involves multiple substances.
Exposure routes	ExposureRoutes	Exposure routes included in assessment.
Restrict active substances to substances with available hazard characterisations	Boolean	Restrict assessment group membership based on presence/absence of hazard characterisations.
Number of simulated days	Numeric	The total duration (in days) of the PBK model simulations.
Number of initial days skipped	Numeric	The initial period (or burn-in period, specified in days) that needs to be skipped when calculating the steady-state or peak internal exposures from the simulated time series.
Use PBK model parameter variability	Boolean	When specified, use parameter variability.
Number of events per day for the DERMAL dose	Numeric	The daily dose is administered in equal portions (dose / number of events) per event.
Number of events per day for the INHALATION dose	Numeric	The daily dose is administered in equal portions (dose / number of events) per event.
Number of events per day for the ORAL dose	Numeric	The daily dose is administered in equal portions (dose / number of events) per event.
Specify the hours (events).	Numeric	Specify the hours on which exposure events are simulated. Allowed numbers are 1, 2, 3, 4,…, 24 separated by spaces.
Specify event timings	Boolean	If checked, a specific sequence of hours on a day can be specified on which exposure events are simulated. Otherwise the events are derived based on the number of exposure events per day.
Exposure events and dose generation method	ExposureEventsGenerationMethod	Generates doses and events for PBK model
PBK simulation method	PbkSimulationMethod	Specifies in which mode to run the PBK model
Lifetime start age in years	Numeric	The starting age (in years) for lifetime range simulation.
Lifetime end age in years	Numeric	The ending age (in years) for lifetime range simulation.
Lifetime window size in years	Numeric	The size of the time window (in years) for the lifetime window simulation.
Use bodyweight adjusted exposures	Boolean	Use bodyweight adjusted exposures in PBK model simulations.

Uncertainty settings

Table 441 Uncertainty settings for module PBK model parametrisations.

Name	Type	Description
Resample PBK model parameter values	Boolean	Specifies whether PBK model parameter values are resampled.