Internal exposures
Internal doses and concentrations are amounts of substances, typically expressed per mass unit and per day, to which individuals in a population are exposed at the chosen target level. This target level is an internal dose or an internal concentration (expressed per unit [organ] weight). Internal exposures may be aggregated from dietary and non-dietary exposures using either absorption factors for systemic doses or kinetic conversion factors or PBK models to translate the external exposures to internal concentrations at the specific target or tissue. Internal exposures can be short-term/acute exposures and then contain exposures for individual-days, or they can be long-term/chronic exposures, in which case they represent the average exposure per day over an unspecified longer time period.
This module has as primary entities: Populations Foods Substances
Output of this module is used by: Exposure mixtures Biological matrix concentration comparisons Risks
Calculation of internal exposures
Internal exposures are computed by linking dietary and (if available) non-dietary individual/individual-day exposures. The (aggregated) internal exposure is computed as an internal concentration at the specified target compartment using kinetic conversion factors or PBK models or as an internal dose that is systemically available in the general circulation using absorption factors.
Inputs used: Dietary exposures Non-dietary exposures Dust exposures Active substances Relative potency factors Absorption factors Kinetic conversion factors PBK model parametrisations
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