Change Log

Version 10.1.3 (2024-12-13)

Added

• Implement first draft version of a working templates example in MCRA Web (#1894)

• Documentation on ‘combining dietary and non-dietary exposures’ (#2040)

• Initial implementation of uploadable PBK models via data module (#2061)

• Initial version of standard action for prospective dietary CRA 2024 (#2068)

• Initial version of standard action for retrospective dietary CRA 2024 (#2079)

• Implement uploading of SBML models (#2072)

• Add ActionType column to MCRA Tasklogs database table (#2077)

Fixed

• Can’t send mail from within MCRA to other user (#1846)

• Model-then-add modeltypes and transformations are not saved (#2080)

Version 10.1.2 (2024-11-08)

Added

• Show last successful and failed login (#1810)

• Implement internal concentration and internal dose (systemic) (#1891)

• Download modular design based on action mappings (#2012)

• Implement expression type for kinetic conversion factors (#2019)

• Implement population alignment methods (#2040)

Changed

• Rename modules: “Human monitoring data” to “HBM occurences” and “Human monitoring analysis” to “HBM analysis” (#2001)

• Hide not-working proast link (#2015)

• Remove enum value AbsorptionFactorModel from InternalModelType, add TargetDoseLevelType.Systemic (#2026)

• Rename HBM Occurences module (previously named human monitoring data) to HBM concentrations (#2039)

Fixed

• Sharing with use rights allows users with administrator role still to download the data (#1934)

• After removing a share, the sharee can still run the action (#1935)

• Terms of use window keeps appearing on repeated logins and doesn’t get saved (#2032)

• Create internal exposures action: remove option “Undefined”, remove option “External dose” issue 2059, 2060 (#2059, #2060)

Version 10.1.1 (2024-09-20)

Added

• Implement PbkModels interface

• Allow plug-in of additional SBML PBK models in frontend and simulation service

• Update frontend with panels and forms for new dust exposure assessment modules

Changed

• Move compartment to target exposures module

• Split kinetic models into AbsorptionFactors (KineticModels) and KineticConversionFactors module

• Remove deprecated and unused setting CodeKineticModel (#2007)

Fixed

• Imported zip of converted full action from standard action opens as standard action (#1984)

• Correct visibility update behaviour of form controls for dynamic setting groups (#2002)

• Notification of new user registration email is not sent (#2016)

Version 10.1.0 (2024-08-15)

Added

• Automated job to disable inactive user accounts (#1715)

• Add rate limiting for failed login attempts (#1809)

Changed

• Restructure MCRA settings XML format to group settings per module (#581)

• Migrate code base from .NET 6 to .NET 8 (#1833)

• Upgrade R to version 4.4.1 and rtools to 4.4 (#1966)

• EFSA 2023 SRAs pro- and retrospective (#1961)

Fixed

• Cannot convert to target matrix blood when blood is not present as sampling method in HBM data (#1960)

Version 10.0.15 (2024-06-21)

Changed

• Update EFSA 2023 Standard actions pro- and retrospective (#1961)

Version 10.0.14 (2024-06-18)

Fixed

• SA Risk steatosis from imazalil seems broken: can’t download action+data as zipped CSV (#1948)

• Remove default CodeFocalEffect from Eu 2023 prospective standard action settings

• Update access level when access level was previously set without subfolders (#1928)

Version 10.0.13 (2024-05-28)

Added

• Add settings tiers for Prospective Dietary CRA (EFSA 2023) (#1924)

Fixed

• Do not show substance weighting of mixtures option in create new action dialog of dietary exposures (#1943)

• Retrospective and prospective SA 2022 defaults, remove checksums from SA definition

Version 10.0.12 (2024-05-21)

Added

• Add password expiration functionality (#1714)

• Kinetic conversion for specific biomarkers in hbm analysis (#1827)

• Extend registration form with fields for organisation, PARC, and purpose (#1920)

• Documentation: add more info on LOD and LOQ imputation (#1904)

Changed

• EU prospective SA 2023 should use gap scenario and default percentage should be 20

• Place standard actions in alphabetic order in window “Create new standard action” (#1914)

• Decouple MCR settings / analysis in different modules (e.g. MCR in Risks and HBM analysis) (#1931)

Fixed

• Selecting checkbox of apply biomarker conversion no longer auto selects convert to checkbox (#1923)

Version 10.0.11 (2024-04-12)

Added

• Filtering of hbm data on time points (#1782)

• Running two opex products for compute action single value non-dietary exposures (#1796)

• Specific gravity from creatinine urine adjustment method by Busgang et al. (#1874)

• Option in to skip privacy sensitive outputs in report (#1882)

• New expression type for specific gravity (#1896)

• Implement new option nondetects handling (#1905)

Changed

• Split Busgang urine specific gravity normalisation into age and non-age dependent methods (#1903)

• Draw from censored lognormal using nondetect and nonquantification information (#1904)

• Updates to EFSA CRA 2023 prospective and retrospective standard actions

Fixed

• Remove hbm analysis option to convert using default value 1 (#1829)

Version 10.0.10 (2024-03-07)

Changed

• Remove conversion factor 1 when target level external in hbm analysis (#1829)

• Update acknowledgement efsa on landing page (#1892)

Added

• Prevent password reuse (#1879)

• Tables for single value non-dietary exposures (#1860)

Version 10.0.9 (2024-02-27)

Added

• New module single value non-dietary exposures (#1733)

• New standard action prospective EFSA data 2019-2021 (#1856)

• Implement ‘use kinetic conversion factor subgroup’ setting (#1868)

• Add specific gravity from creatinine adjusted method Carrieri 2001 (#1874)

Changed

• HBM analysis: update biomarker conversion to allow for biomarker conversion subgroups (age/sex) (#1844)

Fixed

• Kernel calculation in R for violin plots fails when vector contains infinities (#1869)

• Human monitoring analysis settings: order of settings is incorrect (#1876)

Version 10.0.8 (2024-02-12)

Changed

• Update standard action retrospective CRA with EFSA 2019-2021 data (#1823)

• HBM analysis: change order of settings in input form (#1839)

Version 10.0.7 (2024-02-02)

Added

• First draft version of standard action retrospective SRA with EFSA 2019-2021 data (#1823)

Changed

• Add uncertainty columns to RawkineticConversionFactor table (#1845)

Fixed

• Wrong data source version is shown and used in MCRA for a datasource with multiple versions (#1848)

Version 10.0.6 (2024-01-26)

Fixed

• Improve loading speed frontend for large concentration datasets (#1542)

• Add ‘clickjacking’ protection to MCRA website by hiding content when site is loaded in an IFrame

• PDF fails to render due to large AnalyticalMethods section (#1831)

• Can’t delete an MCRA user group when repositories still reference it (#1832)

• Bug in concentration models settings form in frontend: cannot set MRL fallback model (#1834)

Version 10.0.5 (2023-12-21)

Changed

• Additional changes for MCR analysis in risks module (#1784)

Version 10.0.4 (2023-12-18)

Added

• Add general information columns (publication title e.o.) to RPF table (#1772)

• Allow for hazard-characterizations to vary as function of a covariate: example age-dependent HBM-GV for PFAS (#1778)

• Implement MCR analysis in risks module (#1784)

Changed

• Rename MarginOfExposure and HazardIndex of type-definition/enum RiskMetricType (#1705)

Fixed

• Use EN-US number input field with decimal point and not decimal comma (#1781)

Version 10.0.3 (2023-12-01)

Added

• Terms of use and disclaimer (#1583)

• Kinetic conversion models for metabolites (#1683)

• Extend standard action mra metals for effect dnt (#1689)

• Implement BMDL (#1788)

• HBM data exclude substance - sampling method combinations (#1795)

• Show number of non-analysed samples in hbm data samples summary (#1797)

Changed

• MCRA security: make 2FA compulsory for all MCRA accounts (#1765)

• Always show top right help icon in MCRA web app

Fixed

• User groups not visible for non-admin MCRA users

• Remove strong password validation check on Lost QR code form

Version 10.0.2 (2023-10-26)

No changes in MCRA Web

Version 10.0.1 (2023-10-23)

Added

• Bootstrap hbm monitoring data (#1405)

• MCRA security: two-factor authentication (2FA) (#1582)

• Implement PARC-HBM data format reader to support codebook v2.3 (#1649)

• Basic implementation kinetic conversion factors (#1658, #1660)

• Create separate matrix selection settings for kinetic models and HBM analysis (#1684)

• Exclude substances from urine or blood normalisation - standardisation (#1659, #1703)

• Implement kinetic conversion factors (#1695)

• Add biological matrix and expression type to points of departure (POD) data table (#1724)

• Hazard characterisations uncertain (#1742)

Changed

• Update HBM demo standard action on bisphenols to include Karrer kinetic model (#1251)

• Update frontend action details form to show progress spinner on setting/change data sources (#1672)

• Remove action tiers from module definitions to tier/template files per tier (#1673)

• Using new risk metric names for section paths in standard actions (#1679)

• Allow multiple/nested HTML tab panels in output section views

Fixed

• Wrong thousands separator in number of Monte Carlo iterations (#1645)

• Import HBM data should read in correct biological matrix (#1685)

• Convert to single target for hazard characterisations (#1696)

• Substance-specific intraspecies conversion of HC does not work (#1710)

• Delete data folder and show data source usage (#1713)

Version 10.0.0 (2023-06-23)

Public release of Open MCRA Core source code on GitHub.

Changed

• Update short report template for EFSA 2022 acute cranio

• Adjust text on MCRA home page for MCRA 10 (#1627)

• Adjust documentation, settings and URIs for MCRA 10 (#1627)

Fixed

• Inconsistencies in setting visibility and selected module tiers, add documentation (#1632)

• Delete action unnecessarily loads settings (#1646)

• Username is not saved when creating an external repository

• Wrong tier selection in SA EU chronic exposure assessment (2018) and Training Prospective Chronic (#1650)

Version 9.2.10 (2023-06-01)

Changed

• Download loop task output (html, tables, charts) creates a zip file with all sub-task outputs (#1530)

Fixed

• Version number of data source in RPF action input summary shows wrong version (#1604)

• Show correct tier setting for single value risk in SA cranio efsa 2022 (#1635)

Version 9.2.9 (2023-05-24)

Added

• Implement support for missing bodyweights in MCRA (#1585)

• Documentation imputation with zero and biological matrix conversion (#1603)

• Add ‘compare sub tasks’ to single value risk module (#1606)

Changed

• Clean up the contents of the downloadable HTML zip report: move CSV, SVG and metadata files into subfolders (#1361)

• Update EFSA 2022 SRA cranio to use the new EFSA 2022 settings tiers (#1544)

• Update create action wizard of risks module (and single value risks) to include risk metric choice (#1574)

• Update the two standard actions for training prospective CRA with option to run scenario GAP + 20% use (#1621)

Fixed

• Data folders in Workspace data tab are not scrollable (#1572)

• Human monitoring data allows to run without specifying survey (#1593)

• Correct update method of automatic forms so that also the item visibilities are also properly updated after form submission (#1628)

Version 9.2.8 (2023-04-25)

Added

• Update HTML report in zip download with toc-functionality to make it easier to browse through (#1409)

• Risks: Implement cumulative as sum of single-substance ratios (Exposure/Hazard) (#1528)

• Add documentation core and web (#1448)

Fixed

• Data sources view is not updated/refreshed after upload new data source version (#1512)

• User name input check for reset password is not correct (#1594)

• Setting Multiple effects gives error (#1595)

Version 9.2.7 (2023-04-03)

Added

• Separate substance-weighing option for MCR and mixtures analysis and add checkbox to compute or not compute MCR in HBM analysis actions (#1499)

• Show ‘Created’ date in admin users panel (#1523)

• Add standardisation methods for blood and urine (#1359, #1477)

• Implement initial version of SRA acute CRA of craniofacial alterations EFSA 2022 (#1464)

Changed

• Remove MCRA version select page, MCRA 9 is now the default

• Update exposure mixtures module with option to log-transform data before network analysis (#1531)

Fixed

• Hide option for reference substance equivalents when cumulative does not apply for the action (#1502)

Version 9.2.6 (2023-03-10)

Added

• Add compartments including cumulative amounts like urine (#1272)

• Allow hbm as input for risks (#1394)

• Add documentation about allocation of substances (#1473)

• Add new model substance approvals (#1461)

Changed

• Remove service worker functionality from Angular app

• Change MCRA URLs to point to static Documentation URL (#889)

• Move and update documentation section on HBM4EU/PARC HBM data format (#1427)

• Update Angular version to v15.0 (#1468)

• Unique constraint of Hazard Characterisations table is too strict (#1491)

• Keep report name tabs visible when scrolling through report comparison view

Fixed

• File upload failed: max upload file size was not configured correctly

• Fixed subset range editor

• Transaction deadlocked on lock resources in Job scheduler and simulation worker (#1487)

• Job scheduler does not assign jobs correctly (#1489)

• Null reference exception when changing data source (#1501)

• Exception when trying to view task settings in admin tasks panel

• Report comparison fails to load

• Can’t compare outputs of a loop task in tabbed output view, TOC doesn’t work (#1509, #1510)

• Error messages are not displayed correctly in web application

• Missing user account when e-mail verification fails (#1520)

Version 9.2.5 (2023-02-10)

Added

• Documentation: added section on CLI (#1450)

Changed

• Update third party packages (NuGet) for MCRA Web

Fixed

• Failed dataset upload still creates a data source record in the repository (#1483)

Version 9.2.4 (2023-02-03)

Added

• Add documentation of HBM4EU/PARC HBM data format (#1427)

• Add maximum percentage missing value percentage imputation hbm data (#1470)

• Add population characteristics Real Life Mixtures (#1475)

Changed

• Update HBM analysis module to include imputation of missing data method established within HBM4EU/PARC RLM (#1397)

• Update HBM data/analysis module to allow for analysis of concentrations of multiple sampling methods/matrices (#1398)

• Implement changed rules for sending automatic mail from WUR and RIVM (#1466)

• Move internalconcentrationtype to assessment settings

Fixed

• Download action + data (data as zipped csv) fails (#1451)

• Loop task output doesn’t show the comparison between the looped actions (#1459)

• New user registration in MCRA returns 400 Bad Request (#1465)

• Load correct png mime type for safety chart

• Upload of Demo HBM bisphenols standard action data fails (#1472)

Version 9.2.3 (2023-01-16)

Added

• Implement chlorpyrifos kinetic model with metabolites (#1285)

Changed

• Removed unit test report results from admin page (#1441)

• Allow links to MCRA documentation on other servers (#1457)

Fixed

• Documentation shows no version of MCRA in colophon

• Documentation links to web API documentation and web application

• Can’t view info in data browser of a shared data source (#1458)

Version 9.2.2 (2022-12-20)

Added

• Documentation: Add PARC Real-life mixture guidance documents (pdf) and related data to the User guide - Examples section (#1366)

Changed

• Update HBM analysis module with non-detects imputation method according to method established within HBM4EU/PARC RLM (#1396)

Fixed

• Fix reference to dietary exposures section in risks output section (#1331)

• MCRA Build date-time not displayed correctly (#1410)

• Settings in overview only show headers and no settings (#1442)

• Mixtures crashes when no concentrations for HBM data are available (#1443)

• Output collection of task with subtask fails (#1444)

• MCRA settings loading fails: allow floating point literals (NaN, Inf etc) in Json serialization