Demo Human Monitoring Analysis bisphenols
This standard action is of type: Biological matrix concentration comparisons
Human BioMonitoring (HBM) is a primary instrument to measure real-life exposure to chemicals. Because of the associated high costs, chemical levels in body fluids such as blood or urine would ideally be predictable from estimated external exposure levels, such as in the diet and/or from other non-dietary sources. It is needed to convert external exposures to internal concentrations by use of a kinetic (PBK) model or the application of a simple kinetic conversion factor.
This standard action provides a simple demonstration of this approach. It is based on the EuroMix biomonitoring study (Husøy et al. (2019), Karrer et al. (2019)) and considers three of the investigated chemical substances in this study, i.e. the bisphenols BPA, BPS and BPF, which could have adverse estrogenic effects and therefore require risk assessment. These substances were measured in the urine of 144 adult individuals on two days (in this demo, we only use the data of a single day). The study subjects also kept detailed diaries on their food consumption and use of personal care products.
In this demonstrator standard action, the dietary exposure and optionally the non-dietary exposure from personal care products and thermal paper is modelled. HBM measurement values below the limit of detection are imputed. The specific gravity of the urine samples was measured as well, which is used in the calculation to calculate adjusted urine concentrations as decribed in Husøy et al. (Husøy et al. (2019)). The dietary exposure is predicted from the consumption data for 226 modelled foods derived from the food diaries and food monitoring concentration data for BPA, BPS and BPF in these foods. Additionally, non-dietary exposure from personal care products and from handling thermal paper was modelled separately by Karrer et al. (Karrer et al. (2020)) and these exposures are available as data for three non-dietary routes, i.e. dermal, oral and inhalation. These non-dietary exposures can be aggregated with the dietary exposures at the individual level. In this demonstrator the conversion from external exposures to urine concentration can be done using a simple kinetic conversion factor approach or using a PBK model developed by Karrer et al., which is also available in MCRA (Karrer et al. (2018), Karrer et al. (2019), Karrer et al. (2020)).
In this demonstrator standard action several choices can be made:
Exposure type: Select acute or chronic exposure. For acute, HBM data are taken per day and modelled exposures are obtained from 1000 simulated dietary exposures obtained from Monte Carlo integration of individual day consumption patterns and food concentrations and possibly combined/aggregated with matching non-dietary exposures of the simulated individual days. For chronic, HBM data and non-dietary exposure data are averaged per individual and dietary exposures are modelled using the observed individual means model.
Exposure route: Derive modelled concentrations from dietary exposure only or aggregate with non-dietary exposure sources.
Censored valude handling method: For the modelled concentrations, assume censored values in the food concentration data (measurements below the limit of reporting LOR) to be zero or impute them with a value 0.5 x LOR.
Kinetic conversion model: Choose from two example data files with substance-specific absorption factors or use the PBK model developed by Karrer et al.
| Table Group | Name | Repository | Type |
|---|---|---|---|
Compounds |
Demo_HBM_CataloguesAndSecondaryData.xlsx |
Standard Actions/Demo Human Monitoring Analysis |
Fixed |
Effects |
Demo_HBM_CataloguesAndSecondaryData.xlsx |
Standard Actions/Demo Human Monitoring Analysis |
Fixed |
FoodTranslations |
Demo_HBM_CataloguesAndSecondaryData.xlsx |
Standard Actions/Demo Human Monitoring Analysis |
Fixed |
Foods |
Demo_HBM_CataloguesAndSecondaryData.xlsx |
Standard Actions/Demo Human Monitoring Analysis |
Fixed |
RelativePotencyFactors |
Demo_HBM_CataloguesAndSecondaryData.xlsx |
Standard Actions/Demo Human Monitoring Analysis |
Fixed |
Concentrations |
Demo_HBM_ConcentrationsSSD.xlsx |
Standard Actions/Demo Human Monitoring Analysis |
Fixed |
Survey |
Demo_HBM_Consumptions.xlsx |
Standard Actions/Demo Human Monitoring Analysis |
Fixed |
KineticModels |
Demo_HBM_KineticModelsBisphenols_KM.xlsx |
Standard Actions/Demo Human Monitoring Analysis |
Variable |
KineticModels |
Demo_HBM_KineticModelsBisphenols_Sc1.xlsx |
Standard Actions/Demo Human Monitoring Analysis |
Variable |
KineticModels |
Demo_HBM_KineticModelsBisphenols_Sc2.xlsx |
Standard Actions/Demo Human Monitoring Analysis |
Variable |
NonDietary |
Demo_HBM_NonDietaryExposures.xlsx |
Standard Actions/Demo Human Monitoring Analysis |
Fixed |
HumanMonitoringData |
Demo_HBM_PhenolsUrinePooledOneDay.xlsx |
Standard Actions/Demo Human Monitoring Analysis |
Fixed |