Human monitoring analysis
Human monitoring concentrations are substance concentration estimates for a biological matrix (e.g., urine or blood) derived from data obtained from human monitoring studies.
This module has as primary entities: Populations Substances
Output of this module is used by: Exposure mixtures Biological matrix concentration comparisons Risks
Calculation of human monitoring analysis
Human monitoring concentration estimates are computed from data obtained from human monitoring studies. These concentration estimates are computed per substance for a selected (human) biological matrix. Modelling includes imputation of missing values and non-detects, but also correction of concentrations for, e.g., specific gravity. Occasionally, the number of substances measured on the target biological matrix is limited or to low to perform a risk assessment or mixture analysis. If so, matrix conversion is applied: substances measured on other biological matrices are translated to the target matrix after multiplication with a ‘between matrix conversion’ factor. Cumulative risks of multiple substances are calculated using RPFs weighted exposure or using the sum of risk ratio’s method using hazard characterisations.
Inputs used: Human monitoring data Active substances Relative potency factors Kinetic models Exposure biomarker conversions
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