Risks settings
Calculation settings
| Name | Type | Description |
|---|---|---|
Multiple substances analysis
|
Boolean |
Specifies whether the assessment involves multiple substances. |
Compute cumulative risks
|
Boolean |
Specifies whether to compute the combined/cumulative risk over all substances. |
Health effect type
|
HealthEffectType | Specifies whether the health effect is a risk (negative) or benefit (positive). |
Risk metric type
|
RiskMetricType | Report risks in terms of hazard index (HI = 1/MOE) or margin of exposure. |
Show equivalent animal dose output
|
Boolean |
Specifies whether equivalent animal doses should be reported in the output. |
Threshold safety plot
|
Numeric |
Threshold for interpretation in the margin of exposure or hazard index plot, e.g. MOE = HI = 1 or MOE = 100 and HI = 0.01. |
Use inverse distribution to calculate percentile
|
Boolean |
Calculate percentile via the complementary percentage of the inverse distribution (default: no). Description: E.g., P0.1 of MOE distribution is calculated via P99.9 of 1/MOE distribution. Note: This option is provided because percentile calculation in small data sets is asymmetric in both tails. |
Target level
|
TargetLevelType | Select to express hazard characterisations at external or internal exposure level. For an aggregate assessment, that is dietary and nondietary exposure data are combined, the target dose level is always internal. When only dietary exposures are available, the target dose level is optional, i.c. external or internal. |
Risk type
|
ExposureType | The type of exposure considered in the assessment; acute (short term) or chronic (long-term). |
Calculate risks by modelled foods, substances or a combination of the two
|
Boolean |
When the dose target level is external, dietary exposures are directly used as input to risks. Dietary exposures preserve the information of exposure by modelled foods, substances or the combination. Summarizing this information may time consuming. |
Internal concentration
|
InternalConcentrationType | Internal concentrations are derived form dietary and/or non-dietary concentrations and aggregated using a kinetic or absorption factor model or are human monitoring concentrations. |
Cumulative risk calculation method
|
RiskMetricCalculationType | Specify method for computing cumulative risks of multiple substances (e.g., via RPF weighted exposures or as a sum of ratios). |
Output settings
| Name | Type | Description |
|---|---|---|
Number of plot labels
|
Numeric |
Maximum number of labels to plot in hazard vs exposure plot. |
Number of substances in hazard vs. exposure plot
|
Numeric |
Maximum number of substances to plot in hazard vs exposure plot. |
Left margin safety plot
|
Numeric |
Left margin of the plot for margins of exposure or hazard indices. |
Right margin safety plot
|
Numeric |
Right margin of the plot for margins of exposure of hazard indices. |
Inclusion percentage variability interval
|
Numeric |
The central percentage of the variability distribution to include in intervals for exposure, hazard and MOE (e.g. 90 means p5-p95). |
Include drill-down on 9 individuals around specified percentile.
|
Boolean |
Specifies whether drilldown on 9 individuals is to be included in the output. |
Summarize simulated data
|
Boolean |
Specifies whether a summary of the simulated consumptions and concentrations should be included in the output. |
Store simulated individual day exposures
|
Boolean |
Store the simulated individual day exposures. If unchecked, no additional output will be generated. If checked, the output will contain an additional section with the simulated individual day exposures. |
Show percentiles for
|
AlphaNumeric |
Give specific percentiles of exposure distribution (%), e.g. 50 90 95 97.5 99 (space separated). |
Percentage for drilldown
|
Numeric |
Gives detailed output for nine individuals near this percentile of the exposure distribution. |
Percentage for upper tail
|
Numeric |
Gives detailed output for this upper percentage of the exposure distribution. |
Number of levels of covariable to predict exposure
|
Numeric |
Specify the number of levels, e.g. 20. The range of the covariable is divided by the number of levels: range = (max - min)/levels. For these covariable levels exposures are predicted. |
Predict exposure at extra covariable levels
|
Numeric |
Specify specific prediction levels in addition to the automatically generated prediction levels (space separated). |
Lower percentage for variability (%)
|
Numeric |
The default value of 25% may be overruled. |
Upper percentage for variability (%)
|
Numeric |
The default value of 75% may be overruled. |
Report consumptions and exposures per individual instead of per kg body weight
|
Boolean |
Specifies whether body weights should be ignored and consumptions and exposures should be expressed per individual. Otherwise, the consumptions and exposures are per kg body weight. |