Hazard characterisations settings
Selection settings
Name | Type | Description |
---|---|---|
Risk type
|
ExposureType | The type of exposure considered in the assessment; acute (short term) or chronic (long-term). |
Target level
|
TargetLevelType | Select to express hazard characterisations at external or internal exposure level. For an aggregate assessment, that is dietary and nondietary exposure data are combined, the target dose level is always internal. When only dietary exposures are available, the target dose level is optional, i.c. external or internal. |
Consider critical effect
|
Boolean |
Specifies whether the analysis should look at critical effects such as specified in the Hazard characterisation data source. |
Calculation settings
Name | Type | Description |
---|---|---|
Index substance
|
AlphaNumeric |
The substance of interest or index substance. |
Method
|
TargetDosesCalculationMethod | Choose method for computing the hazard characterisations: from in-vivo or in-vitro points of departure or both. |
Expression type
|
PointOfDeparture | Specifies how hazard characterisations are expressed: as BMD, as NOAEL, or the expression type is ignored. |
Selection method in case of multiple candidate hazard characterisations
|
TargetDoseSelectionMethod | Choose either the most toxic (default) or an aggregated hazard characterisation when in nominal runs there are multiple available candidates. In uncertainty runs, multiple candidates are resampled. |
Impute missing hazard characterisations
|
Boolean |
If checked, missing hazard characterisations are imputed based on Munro NOELs or on other available points of departure. |
Imputation method
|
HazardDoseImputationMethodType | Imputation of Hazard characterisations: use low percentile (P5) or unbiased central estimate from either the Munro set or the available POD collection. |
Use BMDs from dose response models
|
Boolean |
If checked, preferably BMDs from dose response models will be used. If these data are not available, other POD data are used. |
Use inter-species conversions
|
Boolean |
Use inter-species conversion factors (default value, e.g. 10, or data). |
Use intra-species factors
|
Boolean |
Use intra-species conversion factors (default value, e.g. 10, or data). |
Use additional assessment factor
|
Boolean |
Use additional assessment factor for extrapolation of PODs to (human) hazard characterisations. |
Include dietary and non-dietary routes of exposure
|
Boolean |
Specifies whether the assessment involves both dietary and non-dietary (oral, inhalatory or dermal) routes of exposure. |
Uncertainty settings
Name | Type | Description |
---|---|---|
Resample intra-species factor
|
Boolean |
Specifies whether intra-species factors are resampled from a parametric uncertainty distribution. |
Resample hazard characterisations or RPFs
|
Boolean |
Specifies whether to resample the hazard characterisations or relative potency factors. Requires hazard characterisation or RPF uncertainty to be quantified in DoseResponseModelsUncertain or RelativePotencyFactorsUncertain tables. |