AOP networks data formats

AOP networks are described using two tables: the AOP networks table, and the effect relations table. The AOP networks table records the ids, names, descriptions, and other metadata of the AOP networks. The effect relations table describes the effects and effect relations (i.e., upstream and downstream key event relations) that are part of the AOP network.

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AOP networks

Data format for specification of adverse outcome pathway (AOP) networks.

Table aliases: AOPNetworks, AOPNetwork.

Table 144 Table definition for AOP networks.
Name Type Description Aliases Required

idAdverseOutcomePathwayNetwork

AlphaNumeric(50)

Unique identification code of the AOP network.

idAOPN, idAOPNetwork, AOPN, AOPNetwork, Id

Yes

Name

AlphaNumeric(100)

Name of the AOP network.

Name

No

Description

AlphaNumeric(200)

Additional description or label of the AOP network.

Description

No

Reference

AlphaNumeric(200)

External reference(s) to sources containing more information about the AOP network. E.g., the AOP wiki, and the associated AOP wiki Ids.

Reference, References

No

idAdverseOutcome

AlphaNumeric(50)

The identification code of the effect representing the adverse outcome of this AOP network.

idAdverseOutcome, idAO, idEffect, AdverseOutcome

Yes

RiskType

ExposureType

The risk type of the adverse outcome. Acute or chronic.

RiskType

No

Effect relations

Dataformat for specification of the effect (key event) relationships of adverse outcome pathway (AOP) networks.

Table aliases: EffectRelations, EffectRelation, EffectRelationships, EffectRelationship, KeyEventRelationships, KeyEventRelationship.

Table 145 Table definition for Effect relations.
Name Type Description Aliases Required

idAdverseOutcomePathwayNetwork

AlphaNumeric(50)

Identification code of the AOP network for which this link is defined.

idAdverseOutcomePathwayNetwork, idAOPN, idAOPNetwork, AOPN, AOPNetwork

Yes

idDownstreamKeyEvent

AlphaNumeric(50)

Identification code of the (triggered) effect of this relationship.

idDownstreamKeyEvent, idEffect, idKeyEvent, Effect, KeyEvent

Yes

idUpstreamKeyEvent

AlphaNumeric(50)

Identification code of the triggering effect of this relationship.

idTrigger, idUpstreamKeyEvent, Trigger

Yes

Reference

AlphaNumeric(200)

External reference(s) to sources containing more information about the effect (key event) relationships.

Reference, References

No