Risks calculation
Probabilistic risk is calculated as a distribution of either margin of exposure (MOE) or hazard index (HI), if at least one of the inputs exposure and hazard characterisation is a distribution. The risk distribution is characterised by percentiles. To accommodate for matching results of MOE and HI=1/MOE in the case of percentiles, there is an option to calculate percentiles via the complementary percentile of the inverse distribution in order to handle numerical differences when calculating percentiles for a left or right tail. E.g. p1 of the MOE distribution can optionally be calculated as 1 divided by p99 of the corresponding 1/MOE distribution. For more details about the graphical displays and the calculations see Individual risks. The option calculate risks by modelled foods is available when the target dose level is external. Dietary exposures preserving all the information of exposures of modelled foods are used to calculate risks statistics for modelled foods and to calculate the percentages at risk of modelled foods in the background and foreground based on the specified threshold in the safety plot.
Calculators