Points of departure data formats
Points of departure, such as NOAELS and BMDs, describe the critical/reference levels of substance dose in relation to the presence or absence of an effect. If available, the uncertainty of externally specified points of departure can be specified with uncertainty sets (empirical distributions representing possible values) in the points of departure uncertainty table.
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Points of departure
Nominal points of departure should be presented in this table. Each point of departure should be linked to an effect using the effect code (idEffect) and to substances using the substance code (idSubstance).
Table aliases: PointsOfDeparture, PointOfDeparture, HazardDoses, HazardDose.
| Name | Type | Description | Aliases | Required |
|---|---|---|---|---|
idModel |
AlphaNumeric(50) |
The dose response model code. |
idDoseResponseModel, idModel, idPod, idPointOfDeparture, Pod, PointOfDeparture |
No |
idEffect |
AlphaNumeric(50) |
The effect code. |
idEffect, EffectId, Effect |
Yes |
idSubstance |
AlphaNumeric(50) |
The code of the substance. |
idSubstance, SubstanceId, SubstanceCode, Substance |
Yes |
Species |
AlphaNumeric(50) |
The species used to obtain this point of departure. |
Species, System |
No |
Point of departure |
Numeric |
Point of departure, can be of various types, e.g. NOAEL, LOAEL, BMD, CED |
PointOfDeparture, LimitDose, HazardDose, Value, CED |
Yes |
Point of departure type |
PointOfDepartureType | The type of the point of departure: e.g. NOAEL, LOAEL, BMD (default). |
PODType, HazardDoseType, LimitDoseType |
No |
DoseUnit |
DoseUnit | The dose unit (if not specified, then mg/kg is assumed). |
DoseUnit, UnitDose |
No |
Benchmark response (BMR) |
AlphaNumeric(100) |
The effect size. |
BenchmarkResponse, CriticalEffectSize, HazardEffectSize |
No |
ExposureRoute |
ExposureRouteType | The route of dose administration used in the study to obtain this point of departure. If not specified exposure route = Dietary is assumed. |
ExposureRoute, RouteExposure |
No |
IsCriticalEffect |
Boolean |
Specifies whether this value is the value associated with the critical effect. If omitted, No is assumed |
IsCriticalEffect |
No |
Points of departure uncertainty
Often, the PODs found for a substance/effect combination are uncertain. This table facilitates in specifying the POD uncertainty in the form of a set of uncertainty values that may additionally be specified for a substance/effect combination.
Table aliases: PointsOfDepartureUncertain, PointOfDepartureUncertain, HazardDosesUncertain, HazardDoseUncertain.
| Name | Type | Description | Aliases | Required |
|---|---|---|---|---|
idDoseResponseModel |
AlphaNumeric(50) |
The dose response model code (must correspond to values in id column of DoseResponseModels table). |
idDoseResponseModel |
Yes |
idUncertaintySet |
AlphaNumeric(50) |
The identification code of the uncertainty set. During an uncertainty iteration one set will be picked to be the POD value. |
idUncertaintySet, UncertaintyId |
Yes |
idEffect |
AlphaNumeric(50) |
The effect code. |
idEffect, EffectId, Effect |
Yes |
idSubstance |
AlphaNumeric(50) |
The code of the substance. |
idSubstance, SubstanceId, SubstanceCode, Substance |
Yes |
Point of departure |
Numeric |
Point of departure, can be of various types, e.g. NOAEL, LOAEL, BMD, CED |
PointOfDeparture, HazardDose, LimitDose, CED |
Yes |
DoseResponseModelParameterValues |
AlphaNumeric(200) |
A comma separated list of the values of the parameters of the model, format: a=1.2,b=3.4,c=5.6 |
DoseResponseModelParameterValues, ParameterValues |
No |