Kinetic models

External exposure can be from on more more exposure routes: oral (dietary or non-dietary), dermal or inhalation. Internal exposure can be systemic or related to a specific compartment in a kinetic model. There are four tiers for relating external to internal exposures (doses):

  1. Assume 100% absorption: internal exposures are equal to external exposures.

  2. Assume conservative absorption factors as suggested by EFSA (EFSA (2014), EFSA (2017a)): oral and inhalation 100%, dermal 50%.

  3. Use externally provided absorption factors (absorption factors data tables).

  4. Use one of the implemented kinetic models, with instances for specific substances defined in data table kinetic model instances and model parameters specified in data table kinetic model instance parameters.

Given a chosen tier, the calculation will fall back to the next lower tier in case of missing data.

This module has as primary entities: Substances

Output of this module is used by: Exposures Hazard characterisations

Kinetic models as data

Specify nondietary absorption factors as data.

Inputs used: Active substances

Settings and Tiers