Hazard characterisations settings¶

Selection settings¶

Table 160 Selection settings for module Hazard characterisations.¶
Name	Description
Risk type	The type of exposure considered in the assessment; acute (short term) or chronic (long-term).
Target level	Select to express hazard characterisations at external or internal exposure level.
Consider critical effect	Specifies whether the analysis should look at critical effects such as specified in the Hazard characterisation data source.

Table 161 Calculation settings for module Hazard characterisations.¶
Name	Description
Method	Choose method for computing the hazard characterisations: from in-vivo or in-vitro points of departure or both.
Expression type	Specifies how hazard characterisations are expressed: as BMD, as NOAEL, or the expression type is ignored.
Selection method in case of multiple candidate hazard characterisations	Choose either the most toxic (default) or an aggregated hazard characterisation when in nominal runs there are multiple available candidates. In uncertainty runs, multiple candidates are resampled.
Impute missing hazard characterisations	If checked, missing hazard characterisations are imputed based on Munro NOELs or on other available points of departure.
Imputation method	Imputation of Hazard characterisations: use low percentile (P5) or unbiased central estimate from either the Munro set or the available POD collection.
Use BMDs from dose response models	If checked, preferably BMDs from dose response models will be used. If these data are not available, other POD data are used.
Use inter-species conversions	Use inter-species conversion factors (default value, e.g. 10, or data).
Use intra-species factors	Use intra-species conversion factors (default value, e.g. 10, or data).
Use additional assessment factor	Use additional assessment factor for extrapolation of PODs to (human) hazard characterisations.
Include dietary and non-dietary routes of exposure	Specifies whether the assessment involves both dietary and non-dietary (oral, inhalatory or dermal) routes of exposure.

Table 162 Uncertainty settings for module Hazard characterisations.¶
Name	Description
Resample intra-species factor	Specifies whether intra-species factors are resampled from a parametric uncertainty distribution.
Resample hazard characterisations or RPFs	Specifies whether to resample the hazard characterisations or relative potency factors. Requires hazard characterisation or RPF uncertainty to be quantified in DoseResponseModelsUncertain or RelativePotencyFactorsUncertain tables.