EU Acute Cumulative Exposure Assessment

This standard action is based on done in 2018 [klaveren:2019a]. In the context of the second framework partnership agreement between the National Institute for Public Health and the Environment of the Netherlands (RIVM) and the European Food Safety Authority (EFSA) acute cumulative dietary exposure assessments were performed for two cumulative assessment groups (CAGs) of pesticides that affect the nervous system: pesticides causing brain and/or erythrocyte AChE inhibition (CAG-NAN, 47 pesticides) and pesticides causing functional alterations of the motor division (CAG-NAM, 100 pesticides). The exposure assessments used monitoring data collected by the Netherlands under their official monitoring programmes in 2014, 2015 and 2016 and individual Dutch food consumption data. Exposure estimates were obtained for each group of pesticides using the MCRA software. The Standing Committee on Plants, Animals, Food and Feed (SC PAFF) discussed the scope of the assessment in 2018 and agreed on the parameters to be used for the cumulative exposure assessment. Based on that discussion, a very conservative tier I modelling approach and a refined, but still conservative tier II modelling approach were used. In these assessments, common risk assessment practice was followed and the cumula-tive exposure was expressed as the total margin of exposure (MOET) at the 50th, 90th, 95th, 99th and 99.9th percentile of the exposure distribution.