AOP networks data formats

AOP networks

AOP networks are described using two tables: the AOP networks table, and the effect relations table. The AOP networks table records the ids, names, descriptions, and other metadata of the AOP networks. The effect relations table describes the effects and effect relations (i.e., upstream and downstream key event relations) that are part of the AOP network.

AOP networks

Data format for specification of adverse outcome pathway (AOP) networks.

Table aliases: AOPNetworks, AOPNetwork, RawAdverseOutcomePathwayNetworks.

Table 126 Table definition for AdverseOutcomePathwayNetworks.

Name	Type	Description	Aliases	Required
idAdverseOutcomePathwayNetwork	AlphaNumeric(50)	Unique identification code of the AOP network.	idAOPN, idAOPNetwork, AOPN, AOPNetwork, Id	Yes
Name	AlphaNumeric(100)	Name of the AOP network.	Name	No
Description	AlphaNumeric(200)	Additional description or label of the AOP network.	Description	No
Reference	AlphaNumeric(200)	External reference(s) to sources containing more information about the AOP network. E.g., the AOP wiki, and the associated AOP wiki Ids.	Reference, References	No
idAdverseOutcome	AlphaNumeric(50)	The identification code of the effect representing the adverse outcome of this AOP network.	idAdverseOutcome, idAO, idEffect, AdverseOutcome	Yes
RiskType	AlphaNumeric(100)	The risk type of the adverse outcome.	RiskType	No

Effect relations

Dataformat for specification of the effect (key event) relationships of adverse outcome pathway (AOP) networks.

Table aliases: EffectRelations, EffectRelation, EffectRelationships, EffectRelationship, KeyEventRelationships, KeyEventRelationship, RawEffectRelations.

Table 127 Table definition for EffectRelations.

Name	Type	Description	Aliases	Required
idAdverseOutcomePathwayNetwork	AlphaNumeric(50)	Identification code of the AOP network for which this link is defined.	idAdverseOutcomePathwayNetwork, idAOPN, idAOPNetwork, AOPN, AOPNetwork	Yes
idDownstreamKeyEvent	AlphaNumeric(50)	Identification code of the (triggered) effect of this relationship.	idDownstreamKeyEvent, idEffect, idKeyEvent, Effect, KeyEvent	Yes
idUpstreamKeyEvent	AlphaNumeric(50)	Identification code of the triggering effect of this relationship.	idTrigger, idUpstreamKeyEvent, Trigger	Yes
Reference	AlphaNumeric(200)	External reference(s) to sources containing more information about the effect (key event) relationships.	Reference, References	No