PBK models settings

Calculation settings

Table 335 Calculation settings for module PBK models.
Name	Type	Description
Multiple substances analysis	Boolean	Specifies whether the assessment involves multiple substances.
Exposure routes	ExposureRoutes	Exposure routes included in assessment.
Restrict active substances to substances with available hazard characterisations	Boolean	Restrict assessment group membership based on presence/absence of hazard characterisations.
Number of simulated days	Numeric	The total duration (in days) of the PBK model simulations.
Number of initial days skipped	Numeric	The initial period (or burn-in period, specified in days) that needs to be skipped when calculating the steady-state or peak internal exposures from the simulated time series.
Use parameter variability	Boolean	When specified, use parameter variability.
Number of events per day for the DERMAL dose	Numeric	The daily dose is administered in equal portions (dose / number of events) per event.
Number of events per day for the INHALATION ose	Numeric	The daily dose is administered in equal portions (dose / number of events) per event.
Number of events per day for the ORAL dose	Numeric	The daily dose is administered in equal portions (dose / number of events) per event.
Specify the hours (events).	Numeric	Specify the hours (events) on which a dose is applied. Allowed numbers are 1, 2, 3, 4,…, 24 separated by spaces.
Specify event timings	Boolean	If checked, a sequence of hours can be specified, otherswise the events are derived based on the number of doses per day.

Table 336 Uncertainty settings for module PBK models.
Name	Type	Description
Resample PBK model parameter values	Boolean	Specifies whether PBK model parameter values are resampled.