Relative potency factors

Relative potency factors (RPFs) quantify potencies of substances with respect to a defined effect, relative to the potency of a chosen index substance. RPFs can be used to express combined exposures of multiple substances in terms of a the exposure value of the chosen index substance (i.e., in index substance equivalents). In MCRA, hazard characterisations, and therefore also RPFs are based on mass units (e.g., µg), and not on mol units. RPFs can be different for different levels of the human organism (external, internal, specific compartment). RPFs can be given as data or computed from hazard characterisations. RPFs can be specified with uncertainty. Computation from uncertain hazard characterisations allows to include correlations between uncertain RPFs which originate from using the same index substance.

This module has as primary entities: Substances Effects

Output of this module is used by: Concentrations Concentration models High exposure food-substance combinations Dietary exposures Internal exposures Exposure mixtures HBM analysis Risks

Relative potency factors as data

Data are provided in the form of a RPF for a specific substance and effect.

• Relative potency factors data formats
• Relative potency factors from data

Inputs used: Active substances AOP networks

Settings used

• Calculation Settings

Calculation of relative potency factors

RPFs are computed from hazard characterisations.

• Relative potency factors calculation

Inputs used: Hazard characterisations

Settings used

• Calculation Settings

Settings and Tiers

• Relative potency factors settings
  • Uncertainty settings