Kinetic modules

Kinetic models convert exposures or hazard characterisations from one or more external routes or compartments to an internal (target) compartment. The reverse conversion from internal to external can also be made (reverse dosimetry).

In a simple tier, kinetic models are specified as absorption factors. In a higher tier, physiologically based toxicokinetic (PBTK) models of a specified type (currently available is the EuroMix generic PBTK model) are linked to MCRA. Kinetic model instances for specific substances and test systems (e.g. cypermethrin in the rat) are specified with parameter sets for the chosen kinetic model.

• Kinetic models