Change Log

Version 10.0.1 (2023-10-23)

Added

  • Bootstrap hbm monitoring data (#1405)

  • MCRA security: two-factor authentication (2FA) (#1582)

  • Implement PARC-HBM data format reader to support codebook v2.3 (#1649)

  • Basic implementation kinetic conversion factors (#1658, #1660)

  • Create separate matrix selection settings for kinetic models and HBM analysis (#1684)

  • Exclude substances from urine or blood normalisation - standardisation (#1659, #1703)

  • Implement kinetic conversion factors (#1695)

  • Add biological matrix and expression type to points of departure (POD) data table (#1724)

  • Hazard characterisations uncertain (#1742)

Changed

  • Update HBM demo standard action on bisphenols to include Karrer kinetic model (#1251)

  • Update frontend action details form to show progress spinner on setting/change data sources (#1672)

  • Remove action tiers from module definitions to tier/template files per tier (#1673)

  • Using new risk metric names for section paths in standard actions (#1679)

  • Allow multiple/nested HTML tab panels in output section views

Fixed

  • Wrong thousands separator in number of Monte Carlo iterations (#1645)

  • Import HBM data should read in correct biological matrix (#1685)

  • Convert to single target for hazard characterisations (#1696)

  • Substance-specific intraspecies conversion of HC does not work (#1710)

  • Delete data folder and show data source usage (#1713)

Version 10.0.0 (2023-06-23)

Public release of Open MCRA Core source code on GitHub.

Changed

  • Update short report template for EFSA 2022 acute cranio

  • Adjust text on MCRA home page for MCRA 10 (#1627)

  • Adjust documentation, settings and URIs for MCRA 10 (#1627)

Fixed

  • Inconsistencies in setting visibility and selected module tiers, add documentation (#1632)

  • Delete action unnecessarily loads settings (#1646)

  • Username is not saved when creating an external repository

  • Wrong tier selection in SA EU chronic exposure assessment (2018) and Training Prospective Chronic (#1650)

Version 9.2.10 (2023-06-01)

Changed

  • Download loop task output (html, tables, charts) creates a zip file with all sub-task outputs (#1530)

Fixed

  • Version number of data source in RPF action input summary shows wrong version (#1604)

  • Show correct tier setting for single value risk in SA cranio efsa 2022 (#1635)

Version 9.2.9 (2023-05-24)

Added

  • Implement support for missing bodyweights in MCRA (#1585)

  • Documentation imputation with zero and biological matrix conversion (#1603)

  • Add ‘compare sub tasks’ to single value risk module (#1606)

Changed

  • Clean up the contents of the downloadable HTML zip report: move CSV, SVG and metadata files into subfolders (#1361)

  • Update EFSA 2022 SRA cranio to use the new EFSA 2022 settings tiers (#1544)

  • Update create action wizard of risks module (and single value risks) to include risk metric choice (#1574)

  • Update the two standard actions for training prospective CRA with option to run scenario GAP + 20% use (#1621)

Fixed

  • Data folders in Workspace data tab are not scrollable (#1572)

  • Human monitoring data allows to run without specifying survey (#1593)

  • Correct update method of automatic forms so that also the item visibilities are also properly updated after form submission (#1628)

Version 9.2.8 (2023-04-25)

Added

  • Update HTML report in zip download with toc-functionality to make it easier to browse through (#1409)

  • Risks: Implement cumulative as sum of single-substance ratios (Exposure/Hazard) (#1528)

  • Add documentation core and web (#1448)

Fixed

  • Data sources view is not updated/refreshed after upload new data source version (#1512)

  • User name input check for reset password is not correct (#1594)

  • Setting Multiple effects gives error (#1595)

Version 9.2.7 (2023-04-03)

Added

  • Separate substance-weighing option for MCR and mixtures analysis and add checkbox to compute or not compute MCR in HBM analysis actions (#1499)

  • Show ‘Created’ date in admin users panel (#1523)

  • Add standardisation methods for blood and urine (#1359, #1477)

  • Implement initial version of SRA acute CRA of craniofacial alterations EFSA 2022 (#1464)

Changed

  • Remove MCRA version select page, MCRA 9 is now the default

  • Update exposure mixtures module with option to log-transform data before network analysis (#1531)

Fixed

  • Hide option for reference substance equivalents when cumulative does not apply for the action (#1502)

Version 9.2.6 (2023-03-10)

Added

  • Add compartments including cumulative amounts like urine (#1272)

  • Allow hbm as input for risks (#1394)

  • Add documentation about allocation of substances (#1473)

  • Add new model substance approvals (#1461)

Changed

  • Remove service worker functionality from Angular app

  • Change MCRA URLs to point to static Documentation URL (#889)

  • Move and update documentation section on HBM4EU/PARC HBM data format (#1427)

  • Update Angular version to v15.0 (#1468)

  • Unique constraint of Hazard Characterisations table is too strict (#1491)

  • Keep report name tabs visible when scrolling through report comparison view

Fixed

  • File upload failed: max upload file size was not configured correctly

  • Fixed subset range editor

  • Transaction deadlocked on lock resources in Job scheduler and simulation worker (#1487)

  • Job scheduler does not assign jobs correctly (#1489)

  • Null reference exception when changing data source (#1501)

  • Exception when trying to view task settings in admin tasks panel

  • Report comparison fails to load

  • Can’t compare outputs of a loop task in tabbed output view, TOC doesn’t work (#1509, #1510)

  • Error messages are not displayed correctly in web application

  • Missing user account when e-mail verification fails (#1520)

Version 9.2.5 (2023-02-10)

Added

  • Documentation: added section on CLI (#1450)

Changed

  • Update third party packages (NuGet) for MCRA Web

Fixed

  • Failed dataset upload still creates a data source record in the repository (#1483)

Version 9.2.4 (2023-02-03)

Added

  • Add documentation of HBM4EU/PARC HBM data format (#1427)

  • Add maximum percentage missing value percentage imputation hbm data (#1470)

  • Add population characteristics Real Life Mixtures (#1475)

Changed

  • Update HBM analysis module to include imputation of missing data method established within HBM4EU/PARC RLM (#1397)

  • Update HBM data/analysis module to allow for analysis of concentrations of multiple sampling methods/matrices (#1398)

  • Implement changed rules for sending automatic mail from WUR and RIVM (#1466)

  • Move internalconcentrationtype to assessment settings

Fixed

  • Download action + data (data as zipped csv) fails (#1451)

  • Loop task output doesn’t show the comparison between the looped actions (#1459)

  • New user registration in MCRA returns 400 Bad Request (#1465)

  • Load correct png mime type for safety chart

  • Upload of Demo HBM bisphenols standard action data fails (#1472)

Version 9.2.3 (2023-01-16)

Added

  • Implement chlorpyrifos kinetic model with metabolites (#1285)

Changed

  • Removed unit test report results from admin page (#1441)

  • Allow links to MCRA documentation on other servers (#1457)

Fixed

  • Documentation shows no version of MCRA in colophon

  • Documentation links to web API documentation and web application

  • Can’t view info in data browser of a shared data source (#1458)

Version 9.2.2 (2022-12-20)

Added

  • Documentation: Add PARC Real-life mixture guidance documents (pdf) and related data to the User guide - Examples section (#1366)

Changed

  • Update HBM analysis module with non-detects imputation method according to method established within HBM4EU/PARC RLM (#1396)

Fixed

  • Fix reference to dietary exposures section in risks output section (#1331)

  • MCRA Build date-time not displayed correctly (#1410)

  • Settings in overview only show headers and no settings (#1442)

  • Mixtures crashes when no concentrations for HBM data are available (#1443)

  • Output collection of task with subtask fails (#1444)

  • MCRA settings loading fails: allow floating point literals (NaN, Inf etc) in Json serialization