Type and Unit definitions

Adjustment factor distribution method types

Accepted justment factor distribution method types.

Table 494 Unit definition for Adjustment factor distribution method types.

Name	Accepted names	Description
No adjustment factor	None	No adjustment factor.
Fixed adjustment factor	Fixed	Fixed adjustment factor.
LogNormal	LogNormal	Lognormal distribution with parameters a and b and offset c (default c = 0).
LogStudents_t	LogStudents_t	Log Students-t distribution with parameters a, b and c and offset d (default d = 0).
Beta	Beta	Beta distribution with shape parameters a and b on interval [c, d], (default = 0, 1).
Gamma	Gamma	Gamma distribution with shape parameter a and rate parameter b with offset = c (default = 0).

Age alignment method

Age alignment method used for the selected exposure source.

Table 495 Unit definition for Age alignment method.

Name	Accepted names	Description
Fit to closest available age	FitClosest	Fit to closest available age.
User defined bins (in years)	AgeBins	User defined bins.

Air body exposure fraction uncertainty distribution types.

Air body exposure fraction uncertainty distribution types.

Table 496 Unit definition for Air body exposure fraction uncertainty distribution types..

Name	Accepted names	Description
LogNormal	LogNormal	Lognormal distribution parameterised by a mean and a coefficient of variation.
Uniform	Uniform	Uniform distribution specified by a mean/median and a coefficient of variation.

Air concentration distribution types.

Air concentration distribution types.

Table 497 Unit definition for Air concentration distribution types..

Name	Accepted names	Description
LogNormal	LogNormal	Lognormal distribution parameterised by a mean and a coefficient of variation.

Air concentration unit

Accepted units for substance concentration volumes.

Table 498 Unit definition for Air concentration unit.

Name	Accepted names
microgram/cubimeter	ugPerm3, ug/m3, ugram/m3, ugr/m3
microgram/liter	ugPerL, ug/L, ugram/L, ugr/L

Application amount unit

Accepted units for consumer product application amounts.

Table 499 Unit definition for Application amount unit.

Name	Accepted names
kilogram	kg, kilograms, kilogr, G167A
gram	g, gram, grams, gr, G148A
milligram	mg, milligrams, milligram

Assessment group membership calculation methods

Accepted Assessment group membership calculation methods.

Table 500 Unit definition for Assessment group membership calculation methods.

Name	Accepted names	Description
Any (crisp)	CrispMax	Assign the highest membership value as membership. For crisp memberships, assign positive substance membership if any model indicates positive membership, and negative membership otherwise.
Majority (crisp)	CrispMajority	Assign positive substance membership if the majority of the membership models indicates positive membership, otherwise, the substance is considered not to be in the assessment group.
Ratio (probabilistic)	ProbabilisticRatio	Express substance membership as a probability ranging from zero (certainly out) to one (certainly in), computed as the average membership score.
Bayesian (probabilistic)	ProbabilisticBayesian	Express substance memberships as a probability with values ranging from zero (certainly out) to one (certainly in) computed using a Bayesian approach.

Benchmark response type

Accepted benchmark response types.

Table 501 Unit definition for Benchmark response type.

Name	Accepted names	Description
Fraction change	FractionChange, FactorChange	The benchmark response is defined as a fraction change of the background response (i.e., defined for both increase and decrease). E.g., for a factor of 0.1, the benchmark response is at +/- 10% of background response.
Percentage change	PercentageChange	The benchmark response is defined as a percentage change of the background response (i.e., defined for both increase and decrease). E.g., for a percentage of 10, the benchmark response is at +/- 10% of background response.
Fraction of background response	Factor, Fraction, FactorOfBackground	The benchmark response is defined as a fraction of the background response. E.g., for a factor of 0.9, the benchmark response is at 0.9 times the background response (i.e., a decrease).
Percentage of background response	Percentage, PercentageOfBackground	The benchmark response is defined as a percentage of the background response. E.g., for a percentage of 90, the benchmark response is at 90% of the background response (i.e., a decrease).
Extra risk	ExtraRisk	For quantal response types. The benchmark dose is defined as the dose that corresponding with an extra risk of a factor times the background risk. A factor of 0.05 corresponds with 5% extra risk.
Additional risk	AdditionalRisk	For quantal response types. The benchmark dose is defined as the dose that corresponding with an additional risk of a factor times the background risk. A factor of 0.05 corresponds with 5% additional risk.
ED50	ED50, Ed50	For quantal response types. The benchmark dose is defined as the dose that corresponds with an estimated risk of 50% (ED50).
Absolute threshold value	Absolute	The benchmark dose is defined as an absolute threshold value.
Absolute difference	Difference	The benchmark dose is defined an absolute difference with the background risk.

Biological matrix

Accepted types of biological matrices.

Table 502 Unit definition for Biological matrix.

Name	Accepted names	Description
Whole body	WholeBody, Body, Whole body, CTotal	Use whole body when the results apply to the whole body.
Blood	Blood, Whole blood, WholeBlood, Full blood, FullBlood, BWB, CPlasmaOut	The complete blood from a standard blood donation.
Blood serum	BloodSerum, Serum, Blood serum, BS	The portion of blood plasma that excludes clotting factors.
Blood plasma	BloodPlasma, Plasma, Blood plasma, O_CP, BP	The liquid component of blood, in which erythrocytes are suspended.
Cord blood	CordBlood, Cord blood, CBWB	Blood that remains in the placenta and in the attached umbilical cord after childbirth.
Cord blood serum	CordBloodSerum, Cord blood serum, CBS	The portion of cord blood plasma that excludes clotting factors.
Cord blood plasma	CordBloodPlasma, Cord blood plasma, CBP	The liquid component of cord blood, in which erythrocytes are suspended.
Venous blood	VenousBlood, Venous blood, O_CV, CVen	The deoxygenated blood which travels from the peripheral blood vessels.
Venous plasma	VenousPlasma	Plasma of the deoxygenated blood which travels from the peripheral blood vessels.
Arterial blood	ArterialBlood, Arterial blood, CArt, O_CA	The oxygenated blood in the circulatory system found in the pulmonary vein.
Arterial plasma	ArterialPlasma	Plasma of the oxygenated blood in the circulatory system found in the pulmonary vein.
Brain blood	BrainBlood, Brain blood, O_CBrb	The blood present in the brain.
Urine	Urine, AurinebpaOut, AurinegOut, AurineTotalOut	A non-invasive matrix definition for urine.
Excreta	Excreta	Human waste (i.e., both urine and feces).
Saliva	Saliva	The extracellular fluid produced and secreted by salivary glands in the mouth.
Semen	Semen	The fluid that is emitted from the male reproductive tract and that contains sperm cells.
Breath	Breath	The condensate of exhaled breath.
Red blood cells	RedBloodCells	The red blood cells.
Breast milk	BreastMilk	The human milk as a biological system.
Fat (adipose) tissue	BodyFat, AdiposeTissue, Adipose Tissue, Body fat, FatTissue, Fat, CFat, O_CF	Adipose tissue, body fat, or simply fat is the main reservoir of fat in the body beneath the skin.
Hair	Hair	The human hair as a non-invasive matrix for biomarkers of exposure.
Toenails	ToeNails	The layer of cells situated at the base of the fingernail or the toenail.
Big toenails	BigToeNails	The layer of cells situated at the base of the big fingernail or the big toenail.
Outer skin	OuterSkin	The extracellular connective tissue matrix of the skin.
Amniotic fluid	AmnioticFluid	The amniotic fluid is the protective liquid contained by the amniotic sac, serves as a cushion for the growing fetus.
Placenta tissue	PlacentaTissue, Placenta	The tissues which support fetal development.
Uterus tissue	UterusTissue, O_CU	The uterus or womb is the organ in the reproductive system that accommodates the fetal development until birth.
Uterus	Uterus	The uterus or womb (organ) as biological matrix.
Liver	Liver, CLiver, O_CL	The liver as biological matrix.
Muscle tissue	MuscleTissue, Muscle, Muscles, CPoor, O_CM	Perfused (muscle) tissue.
Viscera tissue	Viscera, CRich	Perfused tissue of the viscera, the soft internal organs of the body, especially the intestines.
Skin	Skin	Skin of the body.
Viable epidermis exposed skin	ViableEpidermisExposedSkin, SkinViableExposed, ViableSkinExposed, CSkin_e	Viable epidermis of skin exposed to air.
Viable epidermis unexposed skin	ViableEpidermisUnexposedSkin, SkinViableUnexposed, ViableSkinUnexposed, CSkin_u	Viable epidermis of skin not exposed to air.
Stratum corneum of exposed skin	StratumCorneumExposedSkin, StratumCorneumExposed, CSkin_sc_e	The outermost layer of the epidermis, exposed to the open air.
Stratum corneum of unexposed skin	StratumCorneumUnexposedSkin, StratumCorneumUnexposed, CSkin_sc_u	The outermost layer of the epidermis, not exposed to the open air.
Kidney	Kidney, Kidneys	The kidney organ as biological matix.
Adrenal gland	Adrenal, Adrenal gland, Adrenal glands	The adrenal gland as biological matix.
Thyroid gland	Thyroid, Thyroid gland	The thyroid gland as biological matix.
Heart	Heart, O_CH	The heart as biological matix.
Lung	Lung, Lungs, O_CLu	The lung as biological matix.
Brain tissue	BrainTissue	Brain tissue.
Brain	Brain	The brain (organ) as biological matix.
Eyes	Eyes, Eye, Ocular	The eyes as biological matix.
Gonad tissue	Gonad, Gonads, GonadTissue, CGonadOut, O_CBr	The biological matrix of the reproductive system that produces and releases eggs (ovary) or sperm (testicle/testis).
Slowly perfused tissue	SlowlyPerfusedTissue, PoorlyPerfusedTissue, Slowly perfused tissue, O_CS	The biological matrix of poorly perfused tissue include skin and subcutaneous tissue, and resting muscle.
Richly perfused tissue	RichlyPerfusedTissue, Richly perfused tissue, O_CR	The biological matrix of richly perfused tissue include liver, heart, lungs, kidneys, and brain.
Feces	Feces, Excrement, Poop	Bodily waste discharged through the anus.
Air	Air	Inhaled or alveolar air.

Biological organisation type

Accepted biological organisation types.

Table 503 Unit definition for Biological organisation type.

Name	Accepted names	Description
Molecular	Molecular	Molecular level
Cellular	Cellular	Cellular level
Tissue	Tissue	Tissue level
Organ	Organ, Organelle	Organ level
Individual	Individual	Whole body level
Population	Population	Population level

Biomarker conversion distribution type

Biomarker conversion distribution types.

Table 504 Unit definition for Biomarker conversion distribution type.

Name	Accepted names	Description
LogNormal	LogNormal	Lognormal distribution parameterised by a mean and upper p95 percentile.
Uniform	Uniform	Uniform distribution specified by a mean/median and an upper boundary.
Beta	Beta	Beta distribution parameterised by a mean and a variance.

BoD Indicator

Different metrics in which burden of disease can be expressed.

Table 505 Unit definition for BoD Indicator.

Name	Accepted names	Description
DALY	DALY, DALYs	Disability-adjusted life year.
Deaths	Deaths	Number of deaths.
Cases	Cases	Number of cases.
Costs	Costs	Costs.
Prevalence	Prevalence, Prevalences	Prevalence.

Body weight unit

Accepted units for person body weights.

Table 506 Unit definition for Body weight unit.

Name	Accepted names
kilogram	kg, kilograms, kilogr, 3, G167A
gram	g, grams, gr, 0, G148A

Boolean type

Accepted boolean types.

Table 507 Unit definition for Boolean type.

Name	Accepted names
True	True, Yes, T, Y
False	False, F, No, N

Burden of disease approach

Methodologial approach used for estimating the burden of disease attributable to a chemical exposure.

Table 508 Unit definition for Burden of disease approach.

Name	Accepted names	Description
Top-down	TopDown	Top-down approach starting with an estimate of the total burden in the population. A population attributable fraction (PAF) is calculated by applying an exposure response function (ERF) along with observed exposures, thereby estimating the proportion of the overall burden attributable to the chemical exposure. The attributable burden follows from multiplication of the total burden by the PAF.
Bottom-up	BottomUp	Bottom-up approach starting either by estimating the number of new or excess cases based on observed exposures and the exposure response function (ERF), or by evaluating the expected shift in individual responses (e.g. changes in IQ) resulting from exposure. These are translated into a burden measure – often by multiplying by factors such as duration and disability weight (or a monetary value) to calculate the attributable BoD for indicators like DALYs.

Burden of disease indicator uncertainty distribution types.

Burden of disease indicator uncertainty distribution types.

Table 509 Unit definition for Burden of disease indicator uncertainty distribution types..

Name	Accepted names	Description
Normal	Normal	Normal distribution parameterised by a mean and upper p95 percentile.
LogNormal	LogNormal	LogNormal distribution parameterised by a mean and upper p95 percentile.
Triangular	Triangular	Triangular distribution specified by a mode and a lower and upper boundary.

Case control types.

Case control types.

Table 510 Unit definition for Case control types..

Name	Accepted names	Description
Control	Control	Control.
Case	Case	Case.

Cluster method type

Accepted cluster method types.

Table 511 Unit definition for Cluster method type.

Name	Accepted names	Description
Component selection (SNMU)	NoClustering	Only component selection is performed.
Component selection and population subgrouping (SNMU + k-means clustering)	Kmeans	Component selection followed by K-Means clustering of individuals based on their component exposure. K-means classifies individuals in multiple groups (i.e., clusters), such that individuals within the same cluster are as similar as possible (i.e., high intra-class similarity), whereas individuals from different clusters are as dissimilar as possible (i.e., low inter-class similarity). In k-means clustering, each cluster is represented by its center (i.e, centroid) which corresponds to the mean of points assigned to the cluster.
Component selection and population subgrouping (SNMU + hierarchical clustering)	Hierarchical	Component selection followed by hierarchical (Ward’s) clustering of individuals based on their component exposure. Hierachical clustering builds a hierarchy from the bottom-up, and doesn’t require to specify the number of clusters beforehand. Hierarchical clustering produces a tree-based representation of the observations known as a dendrogram.

Combination method membership info and PoD presence types

Accepted Combination method membership info and PoD presence types.

Table 512 Unit definition for Combination method membership info and PoD presence types.

Name	Accepted names	Description
Consider active if POD/HC AND (in-silico) memberships indicate active	Intersection	Consider active if POD/HC AND (in-silico) memberships indicate active.
Consider active if POD/HC OR (in-silico) memberships indicates active	Union	Consider active if POD/HC OR (in-silico) memberships indicates active.

Concentration limit value type

Accepted concentration limit value types.

Table 513 Unit definition for Concentration limit value type.

Name	Accepted names
Maximum residue limit	MaximumResidueLimit, MRL
Proposed maximum residue limit	ProposedMaximumResidueLimit, ProposedMrl

Concentration model types

Accepted Concentration model types.

Table 514 Unit definition for Concentration model types.

Name	Accepted names	Description
Empirical	Empirical	Residues are sampled from the empirical distribution. Fallback: zero.
Censored value Spike LogNormal	NonDetectSpikeLogNormal	A lognormal model (logarithmic transformed values, with parameters mu and sigma^2) is fitted to the positive residues values. LOR information is not used. Fallback (if number of positives less than 2): Empirical, but Maximum Residu Limit for pessimistic assessments.
Censored Spike Truncated LogNormal	NonDetectSpikeTruncatedLogNormal	A truncated lognormal model (with parameters mu and sigma^2) is fitted to the positive residues values. The LOR is used to estimate the truncated left tail of the distribution. Fallback: Lognormal non-detect spike.
Censored LogNormal	CensoredLogNormal	Advanced. A censored lognormal model (with parameters mu and sigma^2) is fitted to the censored and positives residue values. Note, this model is not available when agricultural use information is used. Fallback: Lognormal non-detect spike.
Zero Spike Censored LogNormal	ZeroSpikeCensoredLogNormal	Advanced. A mixture model with zero spike (p0) and censored lognormal model (with parameters mu and sigma^2) is fitted to the censored and positives residue values. Note, this model is not available when agricultural use information is used. Fallback: Censored lognormal.
Censored Spike Maximum Residue Limit	MaximumResidueLimit	Censored Spike Maximum Residue Limit.
Summary statistics	SummaryStatistics	Summary statistics.
LogNormal	LogNormal	Lognormal model.
Constant	Constant	A degenerate propability distribution with a single possible value.

Concentration unit

Accepted units for substance concentrations.

Table 515 Unit definition for Concentration unit.

Name	Accepted names
milligram/kilogram	mgPerKg, mg/kg, milligram/kilogram, milligram/kg, milligr/kg, -6, G049A, G061A
kilogram/kilogram	kgPerKg, kg/kg, kilogram/kilogram, kilogram/kg, 0, G063A
gram/kilogram	gPerKg, g/kg, gram/kilogram, gram/kg, gr/kg, -3, G015A, G060A, G191A
microgram/kilogram	ugPerKg, µg/kg, ug/kg, microgram/kilogram, microgram/kg, microgr/kg, -9, G050A, G076A
nanogram/kilogram	ngPerKg, ng/kg, nanogram/kilogram, nanogram/kg, nanogr/kg, -12, G077A, G080A
picogram/kilogram	pgPerKg, pg/kg, picogram/kilogram, picogram/kg, picogr/kg, -15, G081A
kilogram/liter	kgPerL, kg/l, kg/L, kilogram/liter, kilogram/litre, G017A
gram/liter	gPerL, g/l, g/L, gram/liter, gram/litre, gr/l, gr/L, G016A
milligram/liter	mgPerL, mg/l, mg/L, milligram/liter, milligram/litre, milligr/l, milligr/L, G052A, G062A
microgram/liter	ugPerL, µg/l, ug/L, microgram/liter, microgram/litre, microgr/l, microgr/L, G051A, G079A
nanogram/liter	ngPerL, ng/l, ng/L, nanogram/liter, nanogram/litre, nanogr/l, nanogr/L, G078A
picogram/liter	pgPerL, pg/l, pg/L, picogram/liter, picogram/litre, picogr/l, picogr/L
microgram/milliliter	ugPermL, µg/ml, ug/mL, microgram/milliliter, microgram/millilitre, microgr/ml, microgr/mL
nanogram/milliliter	ngPermL, ng/ml, ng/mL, nanogram/milliliter, nanogram/millilitre, nanogr/ml, nanogr/mL
milligram/deciliter	mgPerdL, mg/dl, milligram/deciliter, milligr/dL, milligr/dl
microgram/gram	ugPerg, µg/g, µgram/gram, µg/gr, ug/g, ugram/gram, ug/gr
nanogram/gram	ngPerg, ng/g, ngram/gram, ngr/gr

Concentration value type

Accepted concentration value type.

Table 516 Unit definition for Concentration value type.

Name	Accepted names	Description
Mean concentration	MeanConcentration, ConcentrationMean, MC	Mean value from the residue trials.
Median concentration	MedianConcentration, MR, STMR, SupervisedTrialMedianResidue	Median concentration / residue value of the positive measurements of the residue trials.
Highest concentration	HighestConcentration, HighestResidue, HR	Highest measured residue / concentration value.
Concentration percentile	Percentile
Limit of quantification	LOQ
Maximum residue limit	MRL

Consumer product application amount distribution types.

Consumer product application amount uncertainty distribution types.

Table 517 Unit definition for Consumer product application amount distribution types..

Name	Accepted names	Description
LogNormal	LogNormal	Lognormal distribution parameterised by a mean and a coefficient of variation.
Uniform	Uniform	Uniform distribution specified by a mean/median and a coefficient of variation.

Consumer product concentration uncertainty distribution types.

Consumer product concentration uncertainty distribution types.

Table 518 Unit definition for Consumer product concentration uncertainty distribution types..

Name	Accepted names	Description
LogNormal	LogNormal	Lognormal distribution parameterised by a mean and a coefficient of variation.
Uniform	Uniform	Uniform distribution specified by a mean/median and a coefficient of variation.

Consumer product concentration unit

Accepted units for substance concentrations in consumer products.

Table 519 Unit definition for Consumer product concentration unit.

Name	Accepted names
microgram/gram	ugPerg, µg/g, µgram/gram, µg/gr, ug/g, ugram/gram, ug/gr
nanogram/gram	ngPerg, ng/g, ngram/gram, ngr/gr
gram/kilogram	gPerKg, g/kg, gram/kilogram, gram/kg, gr/kg, -3, G015A, G060A, G191A
milligram/kilogram	mgPerKg, mg/kg, milligram/kilogram, milligram/kg, milligr/kg, -6, G049A, G061A
microgram/kilogram	ugPerKg, µg/kg, ug/kg, microgram/kilogram, microgram/kg, microgr/kg, -9, G050A, G076A
nanogram/kilogram	ngPerKg, ng/kg, nanogram/kilogram, nanogram/kg, nanogr/kg, -12, G077A, G080A
picogram/kilogram	pgPerKg, pg/kg, picogram/kilogram, picogram/kg, picogr/kg, -15, G081A
gram/liter	gPerL, g/l, g/L, gram/liter, gram/litre, gr/l, gr/L, G016A
milligram/liter	mgPerL, mg/l, mg/L, milligram/liter, milligram/litre, milligr/l, milligr/L, G052A, G062A
microgram/liter	ugPerL, µg/l, ug/L, microgram/liter, microgram/litre, microgr/l, microgr/L, G051A, G079A
nanogram/liter	ngPerL, ng/l, ng/L, nanogram/liter, nanogram/litre, nanogr/l, nanogr/L, G078A
picogram/liter	pgPerL, pg/l, pg/L, picogram/liter, picogram/litre, picogr/l, picogr/L
microgram/milliliter	ugPermL, µg/ml, ug/mL, microgram/milliliter, microgram/millilitre, microgr/ml, microgr/mL
nanogram/milliliter	ngPermL, ng/ml, ng/mL, nanogram/milliliter, nanogram/millilitre, nanogr/ml, nanogr/mL
milligram/deciliter	mgPerdL, mg/dl, milligram/deciliter, milligr/dL, milligr/dl
gram per unit	gPerUnit, g/unit, gram/unit, gr/unit, g, gram, gr
milligram per unit	mgPerUnit, mg/unit, milligram/unit, milligr/unit, mg, milligram, milligr
microgram per unit	ugPerUnit, µg/unit, ug/unit, microgram/unit, microgr/unit, µg, ug, microgram, microgr
nanogram per unit	ngPerUnit, ng/unit, ngram/unit, ngr/unit, ng, ngram, ngr

Consumption intake unit

Accepted units for consumption intake amounts.

Table 520 Unit definition for Consumption intake unit.

Name	Accepted names
gram/kilogram bodyweight/day	gPerKgBWPerDay, g/kg bw, gram/kg bw, g/kg bw/day, gram/kg bw/day, gr/kg bw/day, G212A
gram/day	gPerDay, gram, grams, g/day, gram/day, gr/day

Consumption unit

Accepted units for consumption amounts.

Table 521 Unit definition for Consumption unit.

Name	Accepted names
kilogram	kg, kilograms, kilogr, 3, G167A
gram	g, grams, gr, 0, G148A

Consumption value type

Accepted consumption value types.

Table 522 Unit definition for Consumption value type.

Name	Accepted names
Large portion	LargePortion, LP
Mean consumption	MeanConsumption, MC
Percentile	Percentile, P

Counter factual value uncertainty distribution types.

Counter factual value uncertainty distribution types.

Table 523 Unit definition for Counter factual value uncertainty distribution types..

Name	Accepted names	Description
LogNormal	LogNormal	Lognormal distribution parameterised by a mean and upper p95 percentile.
Uniform	Uniform	Uniform distribution specified by a mean/median and an upper boundary.
Triangular	Triangular	Triangular distribution specified by a mode and a lower and upper boundary.

Covariate model types

Accepted Covariate model types.

Table 524 Unit definition for Covariate model types.

Name	Accepted names	Description
Only constant	Constant	No relation between exposure and e.g. age or gender.
Only covariable	Covariable	Exposure depends on the covariable, e.g. age.
Only cofactor	Cofactor	Exposure depends on the level of the cofactor, e.g. gender.
Both covariable and cofactor	CovariableCofactor	Exposure depends on both covariable and cofactor (additive model).
Both covariable and cofactor and interaction	CovariableCofactorInteraction	Exposure depends on both covariable and cofactor and the effect of the covariable differs for different levels of the cofactor (multiplicative model).

Dietary exposures details level types

Accepted ietary exposures details level types.

Table 525 Unit definition for Dietary exposures details level types.

Name	Accepted names	Description
Full	Full	Show all details.
Restrict to risk-drivers (dietary exposures screening)	OnlyRiskDrivers	Restrict to detailed output for risk-drivers identified by dietary exposures screening.
Omit foods-as-eaten details	OmitFoodsAsEaten	Restrict to detailed output for modelled foods and substances. Omit foods-as-eaten details.

Dose response model type

Accepted dose response model types.

Table 526 Unit definition for Dose response model type.

Name	Accepted names	Description
Exp-m1	Expm1	Exponential model 1
Exp-m2	Expm2	Exponential model 2
Exp-m3	Expm3	Exponential model 3
Exp-m4	Expm4	Exponential model 4
Exp-m5	Expm5	Exponential model 5
Hill-m1	Hillm1	Hill model 1
Hill-m2	Hillm2	Hill model 2
Hill-m3	Hillm3	Hill model 3
Hill-m4	Hillm4	Hill model 4
Hill-m5	Hillm5	Hill model 5
TwoStage	TwoStage
LogLogist	LogLogist
Weibull	Weibull
LogProb	LogProb
Gamma	Gamma
Logistic	Logistic
Probit	Probit
LVM Exp m2	LVM_Exp_M2, LVM Exp m2
LVM Exp m3	LVM_Exp_M3, LVM Exp M3
LVM Exp m4	LVM_Exp_M4, LVM Exp M4
LVM Exp m5	LVM_Exp_M5, LVM Exp M5
LVM Hill m2	LVM_Hill_M2, LVM Hill m2
LVM Hill m3	LVM_Hill_M3, LVM Hill M3
LVM Hill m4	LVM_Hill_M4, LVM Hill M4
LVM Hill m5	LVM_Hill_M5, LVM Hill m5

Dose unit

Accepted units for substance doses.

Table 527 Unit definition for Dose unit.

Name	Accepted names
gram/kilogram bodyweight/day	gPerKgBWPerDay, g/kg bw/day, g/kg/day, gram/kg bw/day, gram/kg/day, gr/kg bw/day, G212A
milligram/kilogram bodyweight/day	mgPerKgBWPerDay, mg/kg bw/day, mg/kg/day, milligram/kg bw/day, milligr/kg bw/day, G211A
microgram/kilogram bodyweight/day	ugPerKgBWPerDay, µg/kg bw/day, µg/kg/day, microgram/kg bw/day, microgram/kg/day, microgr/kg bw/day, microgr/kg/day, G210A
nanogram/kilogram bodyweight/day	ngPerKgBWPerDay, ng/kg bw/day, ng/kg/day, nanogram/kg bw/day, nanogram/kg/day, nanogr/kg bw/day, nanogr/kg/day, G214A
picogram/kilogram bodyweight/day	pgPerKgBWPerDay, pg/kg bw/day, pg/kg/day, picogram/kg bw/day, picogram/kg/day, picogr/kg bw/day, picogr/kg/day
femtogram/kilogram bodyweight/day	fgPerKgBWPerDay, fg/kg bw/day, fg/kg/day, femtogram/kg bw/day, femtogram/kg/day, femtogr/kg bw/day, femtogr/kg/day
gram/gram bodyweight/day	gPerGBWPerDay, g/g bw/day, g/g/day, gram/g bw/day, gram/g/day, gr/g bw/day, gr/g/day
milligram/gram bodyweight/day	mgPerGBWPerDay, mg/g bw/day, mg/g/day, milligram/g bw/day, milligram/g/day, milligr/g bw/day, milligr/g/day
microgram/gram bodyweight/day	ugPerGBWPerDay, µg/g bw/day, µg/g/day, microgram/g bw/day, microgram/g/day, microgr/g bw/day, microgr/g/day
nanogram/gram bodyweight/day	ngPerGBWPerDay, ng/g bw/day, ng/g/day, nanogram/g bw/day, nanogram/g/day, nanogr/g bw/day, nanogr/g/day
picogram/gram bodyweight/day	pgPerGBWPerDay, pg/g bw/day, pg/g/day, picogram/g bw/day, picogram/g/day, picogr/g bw/day, picogr/g/day
femtogram/gram bodyweight/day	fgPerGBWPerDay, fg/g bw/day, fg/g/day, femtogram/g bw/day, femtogram/g/day, femtogr/g bw/day, femtogr/g/day
kilogram/day	kgPerDay, kg/day, kilogram/day, kilogr/day
gram/day	gPerDay, g/day, gram/day, gr/day
milligram/day	mgPerDay, mg/day, milligram/day, milligr/day
microgram/day	ugPerDay, µg/day, microgram/day, microgr/day
nanogram/day	ngPerDay, ng/day, nanogram/day, nanogr/day
picogram/day	pgPerDay, pg/day, picogram/day, picogr/day
femtogram/day	fgPerDay, fg/day, femtogram/day, femtogr/day
kilogram/kilogram	kgPerKg, kg/kg, kilogram/kilogram, kilogram/kg, kg/kg bw
gram/kilogram	gPerKg, g/kg, gram/kilogram, gram/kg, gr/kg, g/kg bw
milligram/kilogram	mgPerKg, mg/kg, milligram/kilogram, milligram/kg, milligr/kg, mg/kg bw, G225A
microgram/kilogram	ugPerKg, µg/kg, microgram/kilogram, microgram/kg, microgr/kg, µg/kg bw
nanogram/kilogram	ngPerKg, ng/kg, nanogram/kilogram, nanogram/kg, nanogr/kg, ng/kg bw
picogram/kilogram	pgPerKg, pg/kg, picogram/kilogram, picogram/kg, picogr/kg, pg/kg bw
molar	M, mol/L
millimolar	mM, mmol/L
micromolar	uM, µM, umol/L
nanomolar	nM, nmol/L
moles	moles, Moles
millimoles	mmoles, mMoles
micromoles	umoles, uMoles
nanomoles	nmoles, nmol, nMoles
gram/kilogram bodyweight/week	gPerKgBWPerWeek, g/kg bw/week, gram/kg bw/week, gr/kg bw/week, G218A
milligram/kilogram bodyweight/week	mgPerKgBWPerWeek, mg/kg bw/week, milligram/kg bw/week, milligr/kg bw/week, G217A
microgram/kilogram bodyweight/week	ugPerKgBWPerWeek, µg/kg bw/week, microgram/kg bw/week, microgr/kg bw/week, G216A
nanogram/kilogram bodyweight/week	ngPerKgBWPerWeek, ng/kg bw/week, nanogram/kg bw/week, nanogr/kg bw/week, G215A
picogram/kilogram bodyweight/week	pgPerKgBWPerWeek, pg/kg bw/week, picogram/kg bw/week, picogr/kg bw/week
femtogram/kilogram bodyweight/week	fgPerKgBWPerWeek, fg/kg bw/week, femtogram/kg bw/week, femtogr/kg bw/week
gram/gram bodyweight/week	gPerGBWPerWeek, g/g bw/week, gram/g bw/week, gr/g bw/week
milligram/gram bodyweight/week	mgPerGBWPerWeek, mg/g bw/week, milligram/g bw/week, milligr/g bw/week
microgram/gram bodyweight/week	ugPerGBWPerWeek, µg/g bw/week, microgram/g bw/week, microgr/g bw/week
nanogram/gram bodyweight/week	ngPerGBWPerWeek, ng/g bw/week, nanogram/g bw/week, nanogr/g bw/week
picogram/gram bodyweight/week	pgPerGBWPerWeek, pg/g bw/week, picogram/g bw/week, picogr/g bw/week
femtogram/gram bodyweight/week	fgPerGBWPerWeek, fg/g bw/week, femtogram/g bw/week, femtogr/g bw/week
kilogram/week	kgPerWeek, kg/week, kilogram/week, kilogr/week
gram/week	gPerWeek, g/week, gram/week, gr/week
milligram/week	mgPerWeek, mg/week, milligram/week, milligr/week
microgram/week	ugPerWeek, µg/week, microgram/week, microgr/week
nanogram/week	ngPerWeek, ng/week, nanogram/week, nanogr/week
picogram/week	pgPerWeek, pg/week, picogram/week, picogr/week
femtogram/week	fgPerWeek, fg/week, femtogram/week, femtogr/week
kilogram/liter	kgPerL, kg/l, kg/L, kilogram/liter, kilogram/litre, G017A
gram/liter	gPerL, g/l, g/L, gram/liter, gram/litre, gr/l, gr/L, G016A
milligram/liter	mgPerL, mg/l, mg/L, milligram/liter, milligram/litre, milligr/l, milligr/L, G052A, G062A
microgram/liter	ugPerL, µg/l, ug/L, microgram/liter, microgram/litre, microgr/l, microgr/L, G051A, G079A
nanogram/liter	ngPerL, ng/l, ng/L, nanogram/liter, nanogram/litre, nanogr/l, nanogr/L, G078A
picogram/liter	pgPerL, pg/l, pg/L, picogram/liter, picogram/litre, picogr/l, picogr/L
milligram/gram	mgPerg, mg/g, milligram/gram
microgram/gram	ugPerg, µg/g, microgram/gram
nanogram/gram	ngPerg, ng/g, nanogram/gram
picogram/gram	pgPerg, pg/g, picogram/gram

Dust adherence amount uncertainty distribution types.

Dust adherence amount uncertainty distribution types.

Table 528 Unit definition for Dust adherence amount uncertainty distribution types..

Name	Accepted names	Description
LogNormal	LogNormal	Lognormal distribution parameterised by a mean and a coefficient of variation.
Uniform	Uniform	Uniform distribution specified by a mean/median and a coefficient of variation.

Dust availability fraction uncertainty distribution types.

Dust availability fraction uncertainty distribution types.

Table 529 Unit definition for Dust availability fraction uncertainty distribution types..

Name	Accepted names	Description
LogNormal	LogNormal	Lognormal distribution parameterised by a mean and a coefficient of variation.
Uniform	Uniform	Uniform distribution specified by a mean/median and a coefficient of variation.

Dust body exposure fraction uncertainty distribution types.

Dust body exposure fraction uncertainty distribution types.

Table 530 Unit definition for Dust body exposure fraction uncertainty distribution types..

Name	Accepted names	Description
LogNormal	LogNormal	Lognormal distribution parameterised by a mean and a coefficient of variation.
Uniform	Uniform	Uniform distribution specified by a mean/median and a coefficient of variation.

Dust concentration uncertainty distribution types.

Dust concentration uncertainty distribution types.

Table 531 Unit definition for Dust concentration uncertainty distribution types..

Name	Accepted names	Description
LogNormal	LogNormal	Lognormal distribution parameterised by a mean and a coefficient of variation.

Dustingestion uncertainty distribution types.

Dust ingestion uncertainty distribution types.

Table 532 Unit definition for Dustingestion uncertainty distribution types..

Name	Accepted names	Description
LogNormal	LogNormal	Lognormal distribution parameterised by a mean and a coefficient of variation.
Uniform	Uniform	Uniform distribution specified by a mean/median and a coefficient of variation.

Effect metric

Accepted types of effect metrics.

Table 533 Unit definition for Effect metric.

Name	Accepted names	Description
Relative risk	RelativeRisk, Relative, RR, Relative Risk	Use relative risk when the risk is expressed as a relative risk.
Odds ratio	OddsRatio, Odds, OR, Odds Ratio	Use odds ratio when the risk is expressed as an odds ratio.
Negative shift	NegativeShift, Negative Shift	Use negative shift when the risk is expressed as a negative shift in a continuous variable.
Positive shift	PositiveShift, Positive Shift	Use positive shift when the risk is expressed as a positive shift in a continuous variable.

Environmental burden of disease standardisation method

Accepted environmental burden of disease standardisation types.

Table 534 Unit definition for Environmental burden of disease standardisation method.

Name	Accepted names	Description
per 10,000	PER10K	EBD standardised per 10,000.
per 100,000	PER100K	EBD standardised per 100,000.
per 1,000,000	PER1M	EBD standardised per 1,000,000.

Estimates nature types

Accepted Estimates nature types.

Table 535 Unit definition for Estimates nature types.

Name	Accepted names	Description
Realistic	Realistic	For lognormal: no censoring at the value of the composite sample concentration, no upper limit to the unit concentration. For Beta: no censoring at the value of the composite sample concentration, unit values are never higher than the number of units in composite sample * value of composite sample concentration.
Conservative	Conservative	For lognormal: unit values will be left-censored at the value of the composite sample concentration, no upper limit to the unit concentration. For Beta: unit values will be left-censored at the value of the value of composite sample concentration, unit are values never higher than the number of units in composite sample * value of composite sample concentration.

Exposure approach method

Accepted Exposure approach method types.

Table 536 Unit definition for Exposure approach method.

Name	Accepted names	Description
Modelled exposures	Modelled	A parametric model is fitted to the data.
Measured exposures	Measured	Data are taken as such.

Exposure approach types

Accepted Exposure approach types.

Table 537 Unit definition for Exposure approach types.

Name	Accepted names	Description
Risk based (RPFs)	RiskBased	Exposures are multiplied by the RPF and thus exposures to different substances are on the same and comparable scale.
Standardised	ExposureBased	All substances are standardised to equal variance (selection of the components will work on patterns of correlation only).
Unstandardised (RPFs = 1)	UnweightedExposures	Exposures as such are taken (unstandardised). This is equivalent to RPFs equal to 1. Thus exposures to different substances are not on the same and comparable scale anymore.

Exposure calculation method

Method types for obtaining exposure estimates.

Table 538 Unit definition for Exposure calculation method.

Name	Accepted names	Description
Modelled exposures	ModelledConcentration	Compute risks from dietary and/or non-dietary routes, aggregated.
Human biomonitoring concentrations	MonitoringConcentration	Compute risks based on exposure estimates obtained from human biomonitoring concentrations.

Exposure events and dose generation

Exposure events generation methods for PBK model simulations.

Table 539 Unit definition for Exposure events and dose generation.

Name	Accepted names	Description
Use usual (average) exposures per route	DailyAverageEvents	Use usual (average) exposures per route, only one event per day.
Use (randomly selected) daily exposures per route	RandomDailyEvents	Use (randomly selected) daily exposures per route and specify events.

Exposure grouping method

Method used for grouping exposures in bins.

Table 540 Unit definition for Exposure grouping method.

Name	Accepted names	Description
Custom bins	CustomBins	Define custom bins by providing bin boundaries.
ERF-defined bins	ErfDefinedBins	Use bins defined by categories in the exposure response function.

Exposure method types

Accepted Exposure method types.

Table 541 Unit definition for Exposure method types.

Name	Accepted names	Description
Manual	Manual	Exposure levels are determined by explicit specification.
Automatic	Automatic	Exposure levels are generated automatically based on the estimated exposure distribution.

Exposure path type

Accepted paths of exposure to chemicals. A path is a combination of a route and the class of exposure sources (i.e., dietary or non-dietary).

Table 542 Unit definition for Exposure path type.

Name	Accepted names	Description
Dietary exposure	Dietary	Dietary exposure.
Oral exposure	Oral	Oral exposure (both from dietary and non-dietary sources).
Dermal exposure	Dermal	Dermal exposure.
Inhalation exposure	Inhalation	Inhalation exposure.
At target	AtTarget	Exposures directly at the target (organ).

Exposure response specification uncertainty distribution types.

Exposure response specification uncertainty distribution types.

Table 543 Unit definition for Exposure response specification uncertainty distribution types..

Name	Accepted names	Description
Normal	Normal	Normal distribution parameterised by a mean and upper p95 percentile.
LogNormal	LogNormal	LogNormal distribution parameterised by a mean and upper p95 percentile.
Triangular	Triangular	Triangular distribution specified by a mode and a lower and upper boundary.
Uniform	Uniform	Uniform distribution specified by a mean and upper boundary.

Exposure response type

Accepted exposure response types.

Table 544 Unit definition for Exposure response type.

Name	Accepted names	Description
Function	Function	Exposure response expressed as function.
PerDoubling	PerDoubling, Doubling	Exposure response expressed as increase per doubling of exposure.
PerUnit	PerUnit, Unit	Exposure response expressed as increase per increase of 1 unit of exposure.
Constant	Constant	Exposure response expressed as constant value.

Exposure route

Accepted routes of exposure to chemicals (i.e., oral, dermal, or inhalation).

Table 545 Unit definition for Exposure route.

Name	Accepted names	Description
Oral	Oral, Dietary	Contact to a chemical via ingestion.
Dermal	Dermal	Exposure via contact between a chemical and the skin.
Inhalation	Inhalation	Exposure via contact between a chemical and the respiratory system.

Exposure source

Accepted types of exposure sources, i.e., the origin of the substance(s) for the purpose of an exposure or risk assessment.

Table 546 Unit definition for Exposure source.

Name	Accepted names	Description
Diet	Diet	Dietary exposure sources.
Air	Air	Air exposure sources.
Dust	Dust	Dust exposure sources.
Soil	Soil	Soil exposure sources.
Consumer products	ConsumerProducts	Consumer product exposure sources.
Other (non-diet)	OtherNonDiet, Other non-dietary	Other non-dietary exposure sources.
Occupational	Occupational	Occupational exposure sources.

Exposure type

Accepted exposure types.

Table 547 Unit definition for Exposure type.

Name	Accepted names	Description
Acute	Acute	Acute exposure.
Chronic	Chronic	Chronic exposure.

Expression type

Expression types define the way in which a substance amount may be standardised, or possible other way expressed. For example, a substance in urine may be expressed in terms of a creatinine standardisation.

Table 548 Unit definition for Expression type.

Name	Accepted names	Description
None	None	No expression type.
Lipids	Lipids	Standardise lipid-soluble substances by total lipid content.
Creatinine	Creatinine	Standardise substance concentrations by creatinine content.
Specific gravity	SpecificGravity, SpecificGravityNormalised, Specific gravity, Specific gravity normalised, SG, SGNormalised, SG normalised	Normalise substance concentrations to specific gravity.

External exposure unit

Accepted units for external exposures.

Table 549 Unit definition for External exposure unit.

Name	Accepted names
gram/kilogram bodyweight/day	gPerKgBWPerDay, g/kg bw/day, g/kg/day, gram/kg bw/day, gr/kg bw/day, G212A
milligram/kilogram bodyweight/day	mgPerKgBWPerDay, mg/kg bw/day, mg/kg/day, milligram/kg bw/day, milligr/kg bw/day, G211A
microgram/kilogram bodyweight/day	ugPerKgBWPerDay, µg/kg bw/day, µg/kg/day, microgram/kg bw/day, microgr/kg bw/day, G210A
nanogram/kilogram bodyweight/day	ngPerKgBWPerDay, ng/kg bw/day, ng/kg/day, nanogram/kg bw/day, nanogr/kg bw/day, G214A
picogram/kilogram bodyweight/day	pgPerKgBWPerDay, pg/kg bw/day, picogram/kg bw/day, picogr/kg bw/day
femtogram/kilogram bodyweight/day	fgPerKgBWPerDay, fg/kg bw/day, fg/kg/day, femtogram/kg bw/day, femtogr/kg bw/day
gram/gram bodyweight/day	gPerGBWPerDay, g/g bw/day, g/g/day, gram/g bw/day, gr/g bw/day
milligram/gram bodyweight/day	mgPerGBWPerDay, mg/g bw/day, mg/g/day, milligram/g bw/day, milligr/g bw/day
microgram/gram bodyweight/day	ugPerGBWPerDay, µg/g bw/day, µg/g/day, microgram/g bw/day, microgr/g bw/day
nanogram/gram bodyweight/day	ngPerGBWPerDay, ng/g bw/day, nanogram/g bw/day, nanogr/g bw/day
picogram/gram bodyweight/day	pgPerGBWPerDay, pg/g bw/day, pg/g/day, picogram/g bw/day, picogr/g bw/day
femtogram/gram bodyweight/day	fgPerGBWPerDay, fg/g bw/day, fg/g/day, femtogram/g bw/day, femtogr/g bw/day
kilogram/day	kgPerDay, kg/day, kilogram/day, kilogr/day
gram/day	gPerDay, g/day, gram/day, gr/day, g/d
milligram/day	mgPerDay, mg/day, milligram/day, milligr/day, mg/d
microgram/day	ugPerDay, µg/day, ug/day, microgram/day, microgr/day, µg/d, ug/d
nanogram/day	ngPerDay, ng/day, nanogram/day, nanogr/day, ng/d
picogram/day	pgPerDay, pg/day, picogram/day, picogr/day, pg/d
femtogram/day	fgPerDay, fg/day, femtogram/day, femtogr/day, fg/d
gram/kilogram	gPerKg, g/kg, gram/kg, gr/kg, G015A
milligram/kilogram	mgPerKg, mg/kg, milligram/kg, milligr/kg, G061A
microgram/kilogram	ugPerKg, µg/kg, microgram/kg, microgr/kg, G050A
nanogram/kilogram	ngPerKg, ng/kg, nanogram/kg, nanogr/kg, G077A
picogram/kilogram	pgPerKg, pg/kg, picogram/kg, picogr/kg, G081A
femtogram/kilogram	fgPerKg, fg/kg, femtogram/kg, femtogr/kg

Focal commodity replacement method types

Accepted Focal commodity replacement method types.

Table 550 Unit definition for Focal commodity replacement method types.

Name	Accepted names	Description
Replace samples with focal commodity samples	ReplaceSamples	Replace all samples of the selected focal commodity/commodities.
Append focal commodity samples	AppendSamples	Add the samples of the focal commodity/commodities to the background concentration data.
Replace measurements of focal food/substance combinations with measurements from focal commodity samples	ReplaceSubstances	Replace the substance concentrations of the background concentrations by substance concentrations from the focal commodity concentration data.
Remove measurements of focal food/substance combinations	MeasurementRemoval	Remove substance measurements for the selected focal food/substance combinations.
Replace measurements of focal food/substance combinations with proposed concentration limit value from data	ReplaceSubstanceConcentrationsByLimitValue	Replace the substance concentrations of the background concentrations with a proposed concentration limit value from data.
Replace measurements of focal food/substance combinations with proposed concentration limit value	ReplaceSubstanceConcentrationsByProposedLimitValue	Replace the substance concentrations of the background concentrations with a proposed concentration limit value (in mg/kg).

Frequency resolution type

Controlled terminology for specification of frequency resolution.

Table 551 Unit definition for Frequency resolution type.

Name	Accepted names	Description
Per day	PerDay, Day	Frequency specified in times per day.
Per week	PerWeek, Week	Frequency specified in times per week.
Per month	PerMonth, Month	Frequency specified in times per month.

Function types

Accepted Function types.

Table 552 Unit definition for Function types.

Name	Accepted names	Description
Polynomial	Polynomial	A polynomial regression fits a nonlinear relationship between the value of the independent variable (e.g. age) and the corresponding conditional mean of y (here the exposure). A polynomial with a degree of 0 is simply a constant function; with a degree of 1 is a line; with a degree of 2 is a quadratic; with a degree of 3 is a cubic, and so on.
Spline	Spline	A spline fits a nonlinear relationship between the value of the independent variable (e.g. age) and the corresponding conditional mean of y (here the exposure). A spline with a degree of 0 is simply a constant function; with a degree of 1 is a line; with a degree of 2 is a quadratic; with a degree of 3 is a cubic, and so on.

Hand protection type

Controlled terminology for type of hand protection.

Table 553 Unit definition for Hand protection type.

Name	Accepted names	Description
None	None	None
Gloves	Gloves	Gloves with unspecified protection level.

Harvest application type

Accepted harvest application types.

Table 554 Unit definition for Harvest application type.

Name	Accepted names	Description
Pre-harvest application	PreHarvest	Pre-harvest application
Post-harvest application	PostHarvest	Post-harvest application

Hazard characterisation type

Accepted hazard characterisation types.

Table 555 Unit definition for Hazard characterisation type.

Name	Accepted names
Benchmark dose	Bmd, BMD
No observed adverse effect level	Noael, NOAEL
Lowest observed adverse effect level	Loael, LOAEL
Acceptable daily intake	Adi, ADI
Acute reference dose	Arfd, ARfD, ARfD (from ADI)
No observed effect level	Noel, NOEL
Tolerable daily intake	Tdi, TDI
Tolerable weekly intake	Twi, TWI
Benchmark dose lower confidence limit of 1%	Bmdl01, BMDL01
Benchmark dose lower confidence limit of 10%	Bmdl10, BMDL10
Human biomonitoring guidance values	Hbmgv, HBMGV
Other	Other

Hazard characterisations calculation method types

Calculation method types for computing hazard characterisations.

Table 556 Unit definition for Hazard characterisations calculation method types.

Name	Accepted names	Description
Compute from points of departure	InVivoPods	Compute from points of departure.
Compute from dose response models	InVitroBmds	Compute from dose response models.
Combine point of departure from index substance with RPFs from dose response models	CombineInVivoPodInVitroDrms	In-vivo Points of Departures for index substance, others using RPFs from in-vitro dose response models

Hazard dose imputation method types

Accepted Hazard dose imputation method types.

Table 557 Unit definition for Hazard dose imputation method types.

Name	Accepted names	Description
Munro P5 (TTC approach)	MunroP5	Use the P5 of the Munro NOEL collection.
Munro central value	MunroUnbiased	Use an unbiased nominal value from the Munro NOEL collection; draw randomly from this collection in the uncertainty runs.
Available hazard characterisations distribution P5	HazardDosesP5	Use the P5 of the available points of departure.
Available hazard characterisations distribution central value	HazardDosesUnbiased	Use an unbiased nominal value from the collection of available points of departure; draw randomly from this collection in the uncertainty runs.

Health effect types

Accepted Health effect types.

Table 558 Unit definition for Health effect types.

Name	Accepted names	Description
Risk	Risk	Health effect is negative (risk).
Benefit	Benefit	Health effect is positive (benefit).

Individual property type

Accepted individual property types.

Table 559 Unit definition for Individual property type.

Name	Accepted names	Description
Categorical	Categorical	Categorical e.g. blood type A, B, AB, O or region East, West, North, South.
Boolean	Boolean	Boolean e.g. yes, no, true, false. See Boolean types unit definitions.
Numeric	Numeric	Numeric, real numbers.
Nonnegative	Nonnegative	Nonnegative real numbers, positive or zero.
Integer	Integer	Integer, integer numbers.
NonnegativeInteger	NonnegativeInteger	NonnegativeInteger integer numbers, positive or zero.
Month	Month	Month. See Month types unit definitions.
DateTime	DateTime	DateTime, period.
Gender	Gender, Sex	Gender or sex. At present, these terms are used interchangeably when making selections on individual properties. See Gender types unit definitions.
Location	Location	Location, country.
Isced	Isced, Education	ISCED, education level. See Isced types unit definitions.
JobTask	JobTask, WorkTask	Job task. See JobTask types unit definitions.

Individual reference set

Methods for obtaining individuals for calculating air exposures.

Table 560 Unit definition for Individual reference set.

Name	Accepted names	Description
Use individuals from individuals module	Simulate	Use individuals from individuals module.
Use individuals from dietary exposures	UseDietaryExposures	Use individuals from dietary exposures module.

Individual reference set

Methods for obtaining individuals for calculating dust exposures.

Table 561 Unit definition for Individual reference set.

Name	Accepted names	Description
Use from individuals module	Simulate	Use individuals from individuals module.
Use individuals from dietary exposures module	UseDietaryExposures	Use individuals from dietary exposures module.

Individual reference set

Methods for obtaining individuals for calculating soil exposures.

Table 562 Unit definition for Individual reference set.

Name	Accepted names	Description
Use individuals from individuals module	Simulate	Use individuals from individuals module.
Use individuals from dietary exposures	UseDietaryExposures	Use individuals from dietary exposures module.

Individual subset types

Methods for selecting/matching survey individuals with a specified/scoped population.

Table 563 Unit definition for Individual subset types.

Name	Accepted names	Description
Match individuals selection to population definition	MatchToPopulationDefinition	Match individuals selection to population definition.
Ignore population definition (use all individuals in survey)	IgnorePopulationDefinition	Ignore population definition (use all individuals in survey).
Match individuals selection to population definition using selected properties only	MatchToPopulationDefinitionUsingSelectedProperties	Match individuals selection to population definition using selected properties only.

Intake model types

Accepted Intake model types.

Table 564 Unit definition for Intake model types.

Name	Accepted names	Description
Observed Individual Means	OIM	Observed Individual Means: just the empirical means over the observed days.
BetaBinomial Normal	BBN	BetaBinomial distribution for frequency of exposure + (transformed) Normal distribution for amounts (de Boer et al. 2009).
Logistic-Normal Normal	LNN0	Logistic-Normal distribution for frequency of exposure + (transformed) Normal distribution for amounts.
Logistic-Normal Normal with correlation	LNN	Logistic-Normal distribution for frequency of exposure + (transformed) Normal distribution for amounts. Both models are estimated taking into account the correlation between exposure frequency and amounts.
Iowa State University Foods model	ISUF	Iowa State University Foods model: semiparametric distribution for frequency of exposure + (transformed) Normal distribution for amounts (de Boer et al. 2009, Dodd (1996)).

Internal model type

Methods for translating between different (internal/external) exposure targets.

Table 565 Unit definition for Internal model type.

Name	Accepted names	Description
Use kinetic conversion factors	ConversionFactorModel, ConversionFactor	Use (low-tier) kinetic conversion factor models.
Use PBK models with fallback on kinetic conversion factors	PBKModel, PBK	Use (high-tier) PBK models with fallback on (low-tier) kinetic conversion factors.
Use PBK models	PBKModelOnly, PBKOnly	Use (high-tier) PBK models.

Isced type

Accepted International Standard Classification of Education (ISCED) types.

Table 566 Unit definition for Isced type.

Name	Accepted names	Description
EarlyChildhoodEducation	ECE, EarlyChildhoodEducation	Early childhood education
PrimaryEducation	PE, PrimaryEducation	Primary education
LowerSecondaryEducation	LSE, LowerSecondaryEducation	Lower secondary education
UpperSecondaryEducation	USE, UpperSecondaryEducation	Upper secondary education
PostSecondaryNonTertiaryEducation	PSNTE, PostSecondaryNonTertiaryEducation	Post-secondary non-tertiary education
ShortCycleTertiaryEducation	SCTE, ShortCycleTertiaryEducation	Short-cycle tertiary education
BachelorsOrEquivalentLevel	BOEL, BachelorsOrEquivalentLevel	Bachelor’s or equivalent level
MastersOrEquivalentLevel	MOEL, MastersOrEquivalentLevel	Master’s or equivalent level
DocteralOrEquivalentLevel	DOEL, DocteralOrEquivalentLevel	Docteral or equivalent level

Job task exposure estimate type

Accepted job exposure estimate types.

Table 567 Unit definition for Job task exposure estimate type.

Name	Accepted names	Description
8h TWA	TWA8h, 8hTWA, 8h TWA	Exposure estimate is an 8-hour time-weighted average (TWA).
LTA	LTA	Long-term average exposure estimate.

Job task exposure unit

Accepted units for job exposure activities.

Table 568 Unit definition for Job task exposure unit.

Name	Accepted names	Description
µg/cm2/day	ugPerCm2PerDay, µg/cm2/day, ug/cm2/day	Exposure expressed in micrograms per square centimeter (µg/cm2) per day.
mg/cm2/day	mgPerCm2PerDay, mg/cm2/day	Exposure expressed in milligrams per square centimeter (mg/cm2) per day.
µg/m3	ugPerM3, µg/m3	Exposure expressed in micrograms per cubic meters (µg/m3).
mg/m3	mgPerM3, mg/m3	Exposure expressed in milligrams per cubic meters (mg/m3).
µg/day	ugPerDay, µg/day, ug/day, µg/d, ug/d	Exposure expressed in micrograms per day (µg/day).
mg/day	mgPerDay, mg/day, mg/d	Exposure expressed in milligrams per day (mg/day).

Job task type

Accepted Job Task types.

Table 569 Unit definition for Job task type.

Name	Accepted names	Description
BathPlating	BP, BathPlating	Bath plating
ChromePaintApplications	CPA, ChromePaintApplications	Chrome paint applications
Machining	MA, Machining	Machining
Welding	WE, Welding	Welding
ThermalSpraying	TS, ThermalSpraying	Thermal spraying
SteelProduction	SP, SteelProduction	Steel production
MaintenanceAndLaboratoryWorkers	MALW, MaintenanceAndLaboratoryWorkers	Maintenance and laboratory workers

Kinetic conversion factor uncertainty distribution types.

Kinetic conversion factor uncertainty distribution types.

Table 570 Unit definition for Kinetic conversion factor uncertainty distribution types..

Name	Accepted names	Description
LogNormal	LogNormal	Lognormal distribution parameterised by a mean and upper p95 percentile.
Uniform	Uniform	Uniform distribution specified by a mean/median and an upper boundary.
InverseUniform	InverseUniform	Inverse uniform distribution specified by a median and an upper boundary.

Kinetic conversion method type

Methods for translating between different (internal/external) exposure targets.

Table 571 Unit definition for Kinetic conversion method type.

Name	Accepted names	Description
Use kinetic conversion factors	ConversionFactorModel, ConversionFactor	Use (low-tier) kinetic conversion factor models.
Use PBK models	PbkModel, PBKModelOnly, PBKOnly	Use (high-tier) PBK models.
Use PBK models with fallback on kinetic conversion factors	PbkWithFallback, PBKModel, PBK	Use (high-tier) PBK models with fallback on (low-tier) kinetic conversion factors.

Left-censored data handling methods

Methods for handling left-censored data (i.e., imputation/substitution).

Table 572 Unit definition for Left-censored data handling methods.

Name	Accepted names	Description
Replace all left-censored values by zero	ReplaceByZero	All left-censored measurements are assumed to be zero’s (set to 0).
Replace all left-censored values by f * LOR	ReplaceByLOR	All left-censored measurements are substituted by f * LOR where f is a constant. Here, the term LOR (limit-of-reporting) is a generic term for LOD and LOQ. If both LOD and LOQ are available, then LOQ is used, also for non-detects (i.e., measurements reported as <LOD).
Replace non-detects by f * LOD and non-quantifications by LOD + f * (LOQ - LOD)	ReplaceByLODLOQSystem	Non-detects are replaced by f * LOD; non-quantifications are replaced by LOD + f * (LOQ - LOD), where f is a constant.
Replace non-detects by 0 and non-quantifications by f * LOQ	ReplaceByZeroLOQSystem	Non-detects are replaced by 0; non-quantifications are replaced by f * LOQ, where f is a constant.

Mean value correction types

Accepted Mean value correction types.

Table 573 Unit definition for Mean value correction types.

Name	Accepted names	Description
Unbiased	Unbiased	The mean of the lognormal is unbiased (bias correction).
Biased	Biased	The mean of the lognormal is biased (no bias correction).

Measurement result type

Specifies the type of a measurement result. E.g., a positive value, a non-detect, or missing value.

Table 574 Unit definition for Measurement result type.

Name	Accepted names	Description
VAL	VAL	Positive measurement greater than zero.
LOD	LOD	Measurement below the limit of detection (LOD).
LOQ	LOQ	Measurement below the limit of quantification (LOQ).
MV	MV	Missing value (MV).

Missing value imputation method types

Missing value imputation method types.

Table 575 Unit definition for Missing value imputation method types.

Name	Accepted names	Description
By zero	SetZero	Set missing values to zero.
Impute from data	ImputeFromData	Replace missing measurements by random other measurements of the same substance, biological matrix and sampling type.
No missing value imputation	NoImputation	No missing value imputation, all missing values remain in the data set and samples with missing values will be removed before analysis.

Modelled foods calculation source types

Accepted Modelled foods calculation source types.

Table 576 Unit definition for Modelled foods calculation source types.

Name	Accepted names	Description
Derive modelled foods from concentrations	DeriveModelledFoodsFromSampleBasedConcentrations	Derive modelled foods from sample based concentration data.
Derive modelled foods from single value concentrations	DeriveModelledFoodsFromSingleValueConcentrations	Derive modelled foods from single value concentrations.
Derive modelled foods from concentration limits	UseWorstCaseValues	Derive modelled foods from concentration limits.

Month type

Accepted months types.

Table 577 Unit definition for Month type.

Name	Accepted names
January	January, Jan, Januari, 1
February	February, Feb, Februari, 2
March	March, Mar, 3
April	April, Apr, 4
May	May, 5
June	June, Jun, 6
July	July, Jul, 7
August	August, Aug, 8
September	September, Sep, Sept, 9
October	October, Oct, 10
November	November, Nov, 11
December	December, Dec, 12

Multiple substance handling method types

Accepted Multiple substance handling method types.

Table 578 Unit definition for Multiple substance handling method types.

Name	Accepted names	Description
Combined assessment of selected substances	Cumulate	Combined assessment of selected substances.
Loop over selected substances	LoopSubstances	Loop over selected substances.

Network analysis type

Accepted Network analysis types.

Table 579 Unit definition for Network analysis type.

Name	Accepted names	Description
No network analysis	NoNetworkAnalysis	No network analysis is applied.
Apply network analysis	NetworkAnalysis	Network analysis is applied on the substance x component (U) matrix.

Nondetect imputation method types

Accepted nondetect imputation method types.

Table 580 Unit definition for Nondetect imputation method types.

Name	Accepted names	Description
Replace by LOR/LOQ/LOD	ReplaceByLimit	Non-quantifications are replaced by f * LOR or f * LOD or by LOD + f * (LOQ - LOD) where f is a constant.
Impute from censored lognormal distribution	CensoredLogNormal	Replace nondetect measurements by a random draw from the lower (left) tail of the censored lognormal distribution.

Occupational exposure calculation method

Available methods for calculating modelled occupational exposures.

Table 581 Unit definition for Occupational exposure calculation method.

Name	Accepted names	Description
Compute for single individual	SingleIndividual	Compute for single individual.
Compute for individual set	IndividualSet	Compute for a set of individuals.

Occupational exposure model type

Exposure model types for occupational exposures.

Table 582 Unit definition for Occupational exposure model type.

Name	Accepted names	Description
Use percentile point	Percentile	Constant model from selected distribution percentile.
Use distribution	Distribution	A parametric model is fitted on the provided distribution percentiles.

Output stratification variable

Supported variables to categorise individuals into distinct subgroups for stratified presentation outputs.

Table 583 Unit definition for Output stratification variable.

Name	Accepted names	Description
Sex	Sex	Stratify individuals by sex.
Occupational scenario	OccupationalScenario	Stratify by occupational scenario.
Case control	CaseControl	Stratify by occupational scenario case control.
Age	Age	Stratify individuals by age group.

PBK model compartment type

PBK model compartment type definitions.

Table 584 Unit definition for PBK model compartment type.

Name	Accepted names
Other	Other
alveolar air compartment	AlveolarAir
arterial blood compartment	ArterialBlood
arterial plasma compartment	ArterialPlasma
Blood compartment	Blood
blood plasma compartment	BloodPlasma
fat compartment	Fat
feces compartment	Feces
gut compartment	Gut
gonads compartment	Gonads
heart compartment	Heart
kidney compartment	Kidney
liver compartment	Liver
lung compartment	Lung
poorly perfused tissue compartment	PoorlyPerfusedTissue
rest-of-body compartment	RestOfBody
richly perfused tissue compartment	RichlyPerfusedTissue
skin compartment	Skin
exposed skin compartment	ExposedSkin
unexposed exposed skin compartment	UnexposedSkin
stratum corneum exposed skin compartment	StratumCorneumExposedSkin
stratum corneum unexposed skin compartment	StratumCorneumUnexposedSkin
urine compartment	Urine
uterus compartment	Uterus
venous blood compartment	VenousBlood
venous plasma compartment	VenousPlasma
viable epidermis exposed skin compartment	ViableEpidermisExposedSkin
viable epidermis unexposed skin compartment	ViableEpidermisUnexposedSkin

PBK model parameter distribution types.

Probability distribution types for PBK model parameters.

Table 585 Unit definition for PBK model parameter distribution types..

Name	Accepted names	Description
LogNormal	LogNormal	Lognormal distribution parameterised by a mean and two coefficients of variation (CVs), one representing variability around the mean and the other reprenting uncertainty of the mean.
Normal	Normal	Normal distribution parameterised by a mean and two standard deviations (SDs), one representing variability around the mean and the other reprenting uncertainty of the mean.
Logistic Normal	LogisticNormal	Logistic Normal distribution parameterised by a mean and two coefficients of variation (CVs), one representing variability around the mean and the other reprenting uncertainty of the mean.
Deterministic	Deterministic, Constant	Deterministic distribution.

PBK model parameter type

PBK model parameter type definitions.

Table 586 Unit definition for PBK model parameter type.

Name	Accepted names	Description
Other	Other
physiological parameter	Physiological
sex	Sex, Gender
age	Age	Age of individual (during simulation).
age	AgeInit	(Initial) age of individual (i.e. at start of simulation).
reference age	AgeRef	Reference age of individual (e.g. age at time of measuring the reference body weight, see reference body weight).
body weight	BodyWeight, BW
reference body weight	BodyWeightRef, BWRef	Reference body weight of individual measured at a certain age.
body surface area	BodySurfaceArea, BSA
body mass index	BodyMassIndex, BMI
height	Height
physicochemical parameter	Physicochemical
molecular weight	MolecularWeight, MW
metabolic parameter	Metabolic
partition coefficient	PartitionCoefficient, PC

PBK model species type

PBK model species type definitions.

Table 587 Unit definition for PBK model species type.

Name	Accepted names	Description
human	Human	Human
Mice	Mice	Mice

PBK output resolution time unit

Time unit for specification of the evaluation/output resolution of PBK model simulations.

Table 588 Unit definition for PBK output resolution time unit.

Name	Accepted names	Description
Use model time unit	ModelTimeUnit	Use model time resolution.
Minutes	Minutes	PBK simulation output resolution is specified in minutes.
Hours	Hours	PBK simulation output resolution is specified in hours.
Days	Days	PBK simulation output resolution is specified in days.

PBK simulation methods

PBK simulation methods.

Table 589 Unit definition for PBK simulation methods.

Name	Accepted names	Description
Standard PBK model simulation	Standard	Standard PBK model simulation, starting at current age and run simulation for specified time period.
Lifetime model simulation from birth to current age	LifetimeToCurrentAge	Run (lifetime) PBK model simulation from birth until current age.
Lifetime model simulation from birth until specified age	LifetimeToSpecifiedAge	Run (lifetime) PBK model simulation from birth until specified age.

Point of departure type

Accepted point of departure types.

Table 590 Unit definition for Point of departure type.

Name	Accepted names
Benchmark dose	Bmd, BMD
No observed adverse effect level	Noael, NOAEL
Lowest observed adverse effect level	Loael, LOAEL
No observed effect level	Noel, NOEL
Median lethal dose	Ld50, LD50
Benchmark dose lower confidence limit of 1%	Bmdl01, BMDL01
Benchmark dose lower confidence limit of 10%	Bmdl10, BMDL10

Point of departure types

Accepted Point of departure types.

Table 591 Unit definition for Point of departure types.

Name	Accepted names	Description
Unspecified (no conversion to common expression type)	FromReference	Do not convert non-standard point of departures.
BMD (convert all hazard characterisations as BMDs)	BMD	Convert all point of departures to bench mark doses.
NOAEL (convert all hazard characterisations as NOAELs)	NOAEL	Convert all point of departures to NOAELs.

Population alignment method

The population alignment method used for the selected exposure source.

Table 592 Unit definition for Population alignment method.

Name	Accepted names	Description
Match completely at random​	MatchRandom	Match completely at random.
Match at individual level	MatchIndividualID, MatchIndividualId	Match at individual level (on individual ID).
Match at random based on cofactors (stratified at random)	MatchCofactors	Match at random based on cofactors (stratified at random).​

Population characteristic distribution types.

Distribution types used to described population characteristics.

Table 593 Unit definition for Population characteristic distribution types..

Name	Accepted names	Description
Normal	Normal	Normal distribution parameterised by a mean and a coefficient of variation.
LogNormal	LogNormal	Lognormal distribution parameterised by a mean and a coefficient of variation.
Uniform	Uniform	Uniform distribution specified by a mean/median and a coefficient of variation.

Population characteristic type

Different characteristic types that can be used to describe a population.

Table 594 Unit definition for Population characteristic type.

Name	Accepted names	Description
IQ	IQ	Intelligence quotient.
BirthWeight	BirthWeight	Body weight of a baby at their birth.

Population size uncertainty distribution types.

Population size uncertainty distribution types.

Table 595 Unit definition for Population size uncertainty distribution types..

Name	Accepted names	Description
Normal	Normal	Normal distribution parameterised by a mean and and upper p95 percentile.
Triangular	Triangular	Triangular distribution specified by a mode and a lower and upper boundary.

Processing distribution type

Accepted processing distribution types.

Table 596 Unit definition for Processing distribution type.

Name	Accepted names	Description
Logistic Normal distribution	LogisticNormal, 1	Logisticnormal distribution.
Log Normal distribution	LogNormal, 2	Lognormal distribution.

Property level type

Accepted property level types.

Table 597 Unit definition for Property level type.

Name	Accepted names	Description
Individual	Individual	Individual level.
IndividualDay	IndividualDay	IndividualDay.

Protective clothing type

Controlled terminology for type of protective clothing.

Table 598 Unit definition for Protective clothing type.

Name	Accepted names	Description
None	None	No protective clothing
Protective clothing	ProtectiveClothing, PC, PPC	Personal protective clothing with unspecified protection level.

RPE type

Controlled terminology for type of RPE.

Table 599 Unit definition for RPE type.

Name	Accepted names	Description
None	None	None
RPE	RPE	RPE

Reference individual set

Reference individual set.

Table 600 Unit definition for Reference individual set.

Name	Accepted names	Description
Diet	Diet	Individuals from the dietary exposures module.
Consumer products	ConsumerProducts	Individuals from the consumer product exposures module.
Air	Air	Individuals from the air exposures module.
Dust	Dust	Individuals from the dust exposures module.
Soil	Soil	Individuals from the soil exposures module.
Individuals	Individuals	Individuals collected/generated in the individuals module.

Response type

Accepted response types.

Table 601 Unit definition for Response type.

Name	Accepted names	Description
Continuous multiplicative	ContinuousMultiplicative	Response values are positive real numbers, e.g., weight, size.
Continuous additive	ContinuousAdditive	Response values are real numbers, e.g., weight change, temperature.
Binary	Binary	Response values have binary outcomes (yes/no, true/false, success/failure, 0/1, etc.).
Quantal	Quantal, Binomial	Response is measured in terms of number of successes out of N possible.
Quantal group	QuantalGroup	Individual responses are measured as binary values, which may be grouped to form a quantal response.
Count	Count	Number of items (cells, molecules, deaths, etc.) in given interval/area/volume.
Ordinal	Ordinal	Relative scores (or graded scores) useable only for ranking.

Risk characterisation ratio

The form of the ratio for expressing risk based on an exposure estimate and a hazard threshold value. This can be either exposure/hazard or hazard/exposure.

Table 602 Unit definition for Risk characterisation ratio.

Name	Accepted names	Description
hazard/exposure	HazardExposureRatio	Express risk as the ratio hazard/exposure (e.g., MOE(T)).
exposure/hazard	ExposureHazardRatio	Express risk as the ratio exposure/hazard (e.g., HI,HQ, RPI).

Riskmetric calculation types

Accepted Riskmetric calculation types.

Table 603 Unit definition for Riskmetric calculation types.

Name	Accepted names	Description
RPF weighted	RPFWeighted	Calculates risk as a single ratio involving cumulative RPF-weighted exposures.
Sum of risk characterisation ratios	SumRatios	Calculate risk as sum of ratios of exposure and hazard.

Selected exposure routes

Selected exposure routes for inclusion in exposure calculations.

Table 604 Unit definition for Selected exposure routes.

Name	Accepted names	Description
Dermal exposure	Dermal	Dermal exposure.
Inhalation exposure	Inhalation	Inhalation exposure.

Sex type

Controlled vocabulary for biological sex (at birth).

Table 605 Unit definition for Sex type.

Name	Accepted names	Description
Female	Female, F, Femme, Frau	Female
Male	Male, M, Homme, Mann	Male

Shift types.

Controlled vocabulary for shift types.

Table 606 Unit definition for Shift types..

Name	Accepted names	Description
Pre-shift	PreShift	Pre-shift.
Post-shift	PostShift	Post-shift.

Shorter than lifetime residue generation method

Methods for generating residues for shorter than lifetime exposure calculations.

Table 607 Unit definition for Shorter than lifetime residue generation method.

Name	Accepted names	Description
Use means	UseMeans	Use means as in chronic exposure calculations.
Random per consumption	RandomPerConsumption	Use random values per consumption, as in acute exposure calculations.

Single value dietary exposures calculation method types

Accepted Single value dietary exposures calculation method types.

Table 608 Unit definition for Single value dietary exposures calculation method types.

Name	Accepted names	Description
IESTI	IESTI	IESTI.
IESTI new	IESTINew	IESTI new.
TMDI	TMDI	Theoretical Maximum Daily Intake.
IEDI	IEDI	International Estimated Daily Intake.
Rees–Day model (I)	NEDI1	Rees–Day model (I).
Rees–Day model (II)	NEDI2	Rees–Day model (II).

Single value risk calculation method types

Accepted Single value risk calculation method types.

Table 609 Unit definition for Single value risk calculation method types.

Name	Accepted names	Description
From single value dietary exposures	FromSingleValues	From single value dietary exposures and hazard characterisations.
As percentile from risks distribution	FromIndividualRisks	As percentile from risks distribution.

Soil concentration uncertainty distribution types.

Soil concentration uncertainty distribution types.

Table 610 Unit definition for Soil concentration uncertainty distribution types..

Name	Accepted names	Description
LogNormal	LogNormal	Lognormal distribution parameterised by a mean and a coefficient of variation.

Soilingestion uncertainty distribution types.

Soil ingestion uncertainty distribution types.

Table 611 Unit definition for Soilingestion uncertainty distribution types..

Name	Accepted names	Description
LogNormal	LogNormal	Lognormal distribution parameterised by a mean and a coefficient of variation.
Uniform	Uniform	Uniform distribution specified by a mean/median and a coefficient of variation.

Standardise blood methods

Accepted Standardise blood methods.

Table 612 Unit definition for Standardise blood methods.

Name	Accepted names	Description
Standardise by total lipid measured via gravimetric analysis	GravimetricAnalysis	Standardise by total lipid measured via gravimetric analysis.
Standardise by total lipid measured via enzymatic summation	EnzymaticSummation	Standardise by total lipid measured via enzymatic summation.
Standardise by derived total lipid content of Triglycerides/Cholesterol (Bernert et al. 2007)	BernertMethod	Standardise by derived total lipid content (Bernert et al. 2007).

Standardise/normalise urine concentration method

Accepted Standardise urine concentration methods based on creatinine.

Table 613 Unit definition for Standardise/normalise urine concentration method.

Name	Accepted names	Description
Normalise by specific gravity	SpecificGravity	Normalise by specific gravity. Levine and Fahy (1945).
Standardise by creatinine concentration	CreatinineStandardisation	Standardise by creatinine concentration.
Normalise by specific gravity derived from creatinine, adults (Carrieri et al. 2001)	SpecificGravityCreatinineAdjustment	A specific gravity adjustment is applied by multiplying a creatinine adjusted concentration with a factor (default 1.48 for adults 18 - 68 year).
Normalise by specific gravity derived from nonlinear modelling of creatinine, children 6 - 14 yr (Busgang et al. 2023, model 1)	SpecificGravityCreatinineNonlinearModelOne	A specific gravity adjustment is applied by nonlinear modelling of a creatinine adjusted concentration, using model 1 of table 3 of Busgang et al. 2023 (children 6 - 14 year).
Normalise by specific gravity derived from nonlinear modelling of creatinine, children 6 - 14 yr, age and gender dependent (Busgang et al. 2023, model 2)	SpecificGravityCreatinineNonlinearModelTwo	A specific gravity adjustment is applied by nonlinear modelling of a creatinine adjusted concentration, using the age and gender dependent model 2 of table 3 of Busgang et al. 2023 (children 6 - 14 year).

Substance group selection method types

Accepted Substance group selection method types.

Table 614 Unit definition for Substance group selection method types.

Name	Accepted names	Description
All substances	IncludeAll	Include all substances of the substances table and use hazard characterisation imputation for missing hazard data.
Restrict to available hazard data	RestrictHazardDoseRpf	Restrict to the substances with available hazard data (either in the form of dose response models or RPFs).
Restrict to available hazard data and possible membership	RestrictHazardDoseRpfAndProbableMembership	Consider only the substances with available hazard data and non-zero membership (i.e., P(AG) > 0).
Restrict to available hazard data and certain membership	RestrictHazardDoseRpfAndCertainMembership	Consider only substances with certain assessment group membership (i.e., P(AG) = 1) and for which a hazard characterisation is available.
Restrict to non-zero membership	RestrictProbableMembership	Consider all substances, use TTC based on the Cramer class for the substances for which no limit dose or RPF is defined.
Restrict to certain membership	RestrictCertainMembership	Consider only the substances with certain assessment group membership (i.e., P(AG) = 1).

Substance translation allocation method types

Accepted Substance translation allocation method types.

Table 615 Unit definition for Substance translation allocation method types.

Name	Accepted names	Description
Random allocation	DrawRandom	Random allocation.
Allocate most potent	UseMostToxic	Allocate most potent active substance.
Allocate least potent	UseLeastToxic	Allocate least potent active substance.
Nominal estimate	NominalEstimates	Allocate nominal estimate (weighted average allocation).
Allocate to all	AllocateToAll	Allocate for each active substance independently as if all concentrations were allocated to this active substance.

Target dose selection method types

Accepted Target dose selection method types.

Table 616 Unit definition for Target dose selection method types.

Name	Accepted names	Description
Select most toxic	MostToxic	Choose the most toxic (default).
Take aggregate	Aggregate	Choose an aggregated hazard characterisation when there there are multiple available candidates in nominal runs.
Random draw	Draw	Draw a random hazard characterisation.

Target level type

The exposure target level indicates whether an exposure/dose is assumed to be an internal (target) concentration, an external dose, or an internal (systemic) dose.

Table 617 Unit definition for Target level type.

Name	Accepted names	Description
External dose	External, ExternalDose	The administered or external dose, often referred to as exposure or intake.
Internal (systemic) dose	Systemic, InternalDose	The absorbed dose is the amount of chemical that is systemically available and can be regarded as the fraction of the external dose that is absorbed and enters the general circulation.
Internal (target) concentration	Internal, InternalConcentration	Internal dose or target dose (tissue dose) is the amount of chemical present in a specific target of interest, i.c. a concentration.

Test system type

Accepted test system types.

Table 618 Unit definition for Test system type.

Name	Accepted names	Description
In vivo	InVivo	In vivo
Cell line	CellLine	CellLine
Primary cells	PrimaryCells, StemCells, Embryo	PrimaryCells
Tissue	Tissue	Tissue
Organ	Organ	Organ

Testing method types

Accepted testing method types.

Table 619 Unit definition for Testing method types.

Name	Accepted names	Description
Backward	Backward	Backward selection starts with selecting a model with a function of the highest degree. Then, the degree of the function is decreased by one and the model is tested again. This process is repeated until decreasing the degree does not improve the model fit anymore.
Forward	Forward	Forward selections starts with selecting a model with a function of the lowest degree. Then, the degree of the function is increased by one and the model is tested again. This process is repeated until increasing the degree does not improve the model fit anymore.

Time unit

Supported time units.

Table 620 Unit definition for Time unit.

Name	Accepted names	Description
seconds	Seconds, sec	Seconds
minutes	Minutes, min	In minutes
hours	Hours, h	In hours
days	Days, d	days

Transform types

Accepted Transform types.

Table 621 Unit definition for Transform types.

Name	Accepted names	Description
Logarithmic	Logarithmic	Exposure amounts are transformed to normality using a logarithmic transformation.
No transformation	NoTransform	Exposure amounts are not transformed.
Power	Power	Exposure amounts are transformed to normality using a Box-Cox power transformation.

Uncertainty types

Accepted Uncertainty types.

Table 622 Unit definition for Uncertainty types.

Name	Accepted names	Description
Empirical	Empirical	Data are taken as such.
Parametric	Parametric	A parametric model is fitted to the data.

Unit variability correlation types

Accepted Unit variability correlation types.

Table 623 Unit definition for Unit variability correlation types.

Name	Accepted names	Description
No correlation	NoCorrelation	The unit residue values for unit portions (consumption amount/unitweight) are randomly drawn, explicitly ignoring any correlation between unit residues.
Full correlation	FullCorrelation	The unit residue values for unit portions (consumption amount/unitweight) are randomly drawn, explicitly introducing correlation between unit residues, e.g. high (small) values occur more frequently together.

Unit variability model types

Accepted Unit variability model types.

Table 624 Unit definition for Unit variability model types.

Name	Accepted names	Description
Beta distribution	BetaDistribution	Requires knowledge of the number of units in a composite sample, and of the variability between units (realistic or conservative estimates). Under the beta model, the simulated unit values are drawn from a bounded distribution on the interval.
Lognormal distribution	LogNormalDistribution	Requires only knowledge of the variability between units (realistic or conservative estimates). The lognormal distribution is considered as an appropriate model for many empirical positive concentration distributions (unbounded distribution).
Bernoulli distribution	BernoulliDistribution	Requires only knowledge of the number of units in a composite sample (results are always conservative). The bernoulli model is a limiting case of the beta model, which can be used if no information on unit variability is available, but only the number of units in a composite sample is known.

Unit variability types

Accepted Unit variability types.

Table 625 Unit definition for Unit variability types.

Name	Accepted names	Description
Variation coefficient	VariationCoefficient	Standard deviation divided by the mean.
Variability factor	VariabilityFactor	Defined as 97.5th percentile divided by the mean.

Unit weight value type

Accepted unit weight types.

Table 626 Unit definition for Unit weight value type.

Name	Accepted names	Description
Unit weight RAC	UnitWeightRac, UnitWeightRAC, RAC, UnitWeightRawAgriculturalCommodity	Unit weight raw agricultural commodity (RAC).
Unit Weight EP	UnitWeightEp, EP, UnitWeightEP, UnitWeightEdiblePortion	Unit weight edible portion (EP).

Value qualifier

Supported value qualifiers.

Table 627 Unit definition for Value qualifier.

Name	Accepted names
=	Equals, =
<	LessThan, lt, <

Ventilatory flow rate variability distribution types.

Ventilatory flow rate variability distribution types.

Table 628 Unit definition for Ventilatory flow rate variability distribution types..

Name	Accepted names	Description
LogNormal	LogNormal	Lognormal distribution parameterised by a mean and a coefficient of variation.

Within bin exposure representation method

Method used for selecting the value within a bin that should represent the exposure for the bin.

Table 629 Unit definition for Within bin exposure representation method.

Name	Accepted names	Description
Minimum in bin	MinimumInBin	Minimum exposure value within the bin.
Maximum in bin	MaximumInBin	Maximum exposure value within the bin.
Average in bin	AverageInBin	Average exposure value within the bin.