Kinetic conversion factors settings

Calculation settings

Table 419 Calculation settings for module Kinetic conversion factors.

Name	Type	Description
Exposure type	ExposureType	The type of exposure considered in the assessment; acute (short term) or chronic (long-term).
Multiple substances analysis	Boolean	Specifies whether the assessment involves multiple substances.
Exposure routes	ExposureRoutes	Exposure routes included in assessment.
Restrict active substances to substances with available hazard characterisations	Boolean	Restrict assessment group membership based on presence/absence of hazard characterisations.
Use kinetic conversion factors subgroup	Boolean	Kinetic conversion factors are dependent on subgroups (e.g. based on age or gender, see dataformats KineticConversionfactorsSGs).
Target biological matrix	BiologicalMatrix	The internal target/matrices for which kinetic conversion factors are to be computed.
PBK model simulations	Numeric	Number of PBK model simulations used to derive kinetic conversion factors from PBK model simulations.
Exposure range minimum	Numeric	Minimum of the external exposure range for PBK model simulations used to derive kinetic conversion factors from PBK model simulations.
Exposure range maximum	Numeric	Maximum of the external exposure range for PBK model simulations used to derive kinetic conversion factors from PBK model simulations.
Compute between internal target conversion factors	Boolean	Compute kinetic conversion factors to extrapolate exposures/concentrations between internal targets/matrices.
Number of simulated days	Numeric	The total duration (in days) of the PBK model simulations.
Exposure events and dose generation method	ExposureEventsGenerationMethod	Generates doses and events for PBK model
Number of initial days skipped	Numeric	The initial period (or burn-in period, specified in days) that needs to be skipped when calculating the steady-state or peak internal exposures from the simulated time series.
Number of initial years skipped	Numeric	The initial period (or burn-in period, specified in years) that needs to be skipped when calculating the steady-state or peak internal exposures from the simulated time series.
Use PBK model parameter variability	Boolean	When specified, use parameter variability.
PBK simulation method	PbkSimulationMethod	Specifies in which mode to run the PBK model
Expected life time in years	Numeric	The total expected lifetime (in years) of the PBK model.
Use bodyweight adjusted exposures	Boolean	Use bodyweight adjusted exposures in PBK model simulations.
PBK output resolution time unit	PbkModelOutputResolutionTimeUnit	Time unit in which the output resolution of PBK model simulations is specified.
PBK output resolution step size	Numeric	PBK model simulation output step size/length, specifying the evaluation resolution in terms of the step length (period) between two evaluations. For example, a step length of 12 with a resolution time unit of hours is interpreted as every 12 hours.
Seed for pseudo-random number generator	Numeric	A value of 0 will use a pseudo-random seed in each run, a value > 0 will provide the same results in a repeated run.

Uncertainty settings

Table 420 Uncertainty settings for module Kinetic conversion factors.

Name	Type	Description
Resample kinetic conversion factors	Boolean	Specifies whether kinetic conversion factors are resampled.