Concentration models tiers

In addition to the possibility for users to work with their own choices for all settings, MCRA implements four tiers from two documents:

The optimistic and pessimistic basic assessments from the EFSA 2012 Guidance on the Use of Probabilistic Methodology for Modelling Dietary Exposure to Pesticide Residues (EFSA (2012)).
Tier 1 and 2 from the European Commission working document SANTE-2015-10216 rev. 7 (2018) on risk management aspects related to the assessment of cumulative exposure (EC (2018)).

Overview

Table 53 Tier overview for module Concentration models.
Name	EC 2018 Acute Tier I	EC 2018 Chronic - Tier I	EC 2018 Acute Tier II	EC 2018 Chronic Tier II	EFSA 2012 Optimistic	EFSA 2012 Acute Pessimistic	EFSA 2012 Chronic Pessimistic	EFSA 2022 Acute Tier I	EFSA 2022 Chronic Tier I	EFSA 2022 Acute Tier II	EFSA 2022 Chronic Tier II	EFSA 2023 Acute Prospective Tier II	EFSA 2023 Chronic Prospective Tier II
Default concentration model	Empirical	Empirical	Empirical	Empirical	Empirical	NonDetectSpikeLogNormal	NonDetectSpikeLogNormal	Empirical	Empirical	Empirical	Empirical	Empirical	Empirical
Include MRL fallback model	false	false	false	false	false	true	true	false	false	false	false	false	false
Restrict LOR imputation to authorised uses	false	false	false	false		false	false	false	false	false	false	false	false
Censored values replacement	ReplaceByLOR	ReplaceByLOR	ReplaceByLOR	ReplaceByLOR	ReplaceByZero	ReplaceByLOR	ReplaceByLOR	ReplaceByLOR	ReplaceByLOR	ReplaceByLOR	ReplaceByLOR	ReplaceByLOR	ReplaceByLOR
Factor f (f x LOR or f x LOD or LOD + f x (LOQ - LOD)	0.5	0.5	0.5	0.5		1	1	0.5	0.5	0.5	0.5	0.5	0.5
Sample based	true	true	true	true	true	true	true	true	true	true	true	true	true
Impute missing values from available values (if unchecked, missing values are imputed with 0)	true	true	true	true	false	true	true	true	true	true	true	true	true
Correlate imputed values with sample potency	true	true	false	false	false	true	true	true	true	false	false	false	false
Use occurrence frequencies for imputation	true	true	true	true	false			true	true	true	true	true	true
Parametric uncertainty	false	false	false	false	false	true	false	false	false	false	false	false	false
Filter samples exceeding the concentration limits	false	false	false	false		false	false	false	false	false	false	true	true
Use substance conversion rules	true	true	true	true				true	true	true	true	true	true
Substance conversion method	UseMostToxic	UseMostToxic	DrawRandom	DrawRandom				UseMostToxic	UseMostToxic	DrawRandom	DrawRandom	DrawRandom	DrawRandom
Retain all allocated substances after active substance allocation	true	true	true	true				true	true	true	true	true	true
Account for substance authorisations in substance conversions	false	false	true	true				false	false	true	true	true	true
Fix duplicate substance allocation inconsistencies	false	false	false	false				false	false	false	false	false	false
Use extrapolation rules	true	true	true	true				false	false	false	false	false	false
Threshold for extrapolation	10	10	10	10
Restrict extrapolations to equal MRLs	true	true	true	true
Restrict extrapolations to authorised uses	true	true	true	true
Impute water concentrations	true	true	true	true				true	true	true	true	true	true
Water concentration value (µg/kg)	0.1	0.1	0.05	0.05				0.1	0.1	0.05	0.05	0.05	0.05
Restrict water imputation to the five most toxic substances	true	true	true	true				true	true	true	true	true	true
Restrict water imputation to authorised uses	false	false	false	false				false	false	false	false	false	false
Restrict water imputation to approved substances	false	false	false	false				true	true	true	true	true	true
Apply occurrence pattern percentages	false	false	true	true				false	false	true	true	true	true
Scale up use frequency to 100%			true	true						true	true	true	true
Restrict use percentage up-scaling to authorised uses			true	true						true	true	true	true
MRL Factor (f x MRL)						1	1
Concentration limit filter exceedance factor												2	2
Include focal commodity concentrations												true	true
Focal commodity concentrations replacement method												ReplaceSubstances	ReplaceSubstances
Focal commodity substance occurrence percentage												20	20
Adjustment factor for the focal food/substance concentration												1	1
Use deterministic substance conversions for focal commodity												true	true

The sections below describe the settings specified by each tier in detail.

Retrospective dietary CRA (EC 2018) - Acute / Tier I

Table 54 Tier definition for Retrospective dietary CRA (EC 2018) - Acute / Tier I.
Name	Setting	From input tier	In module
Default concentration model	Empirical
Include MRL fallback model	false
Restrict LOR imputation to authorised uses	false
Censored values replacement	ReplaceByLOR
Factor f (f x LOR or f x LOD or LOD + f x (LOQ - LOD)	0.5
Sample based	true
Impute missing values from available values (if unchecked, missing values are imputed with 0)	true
Correlate imputed values with sample potency	true
Use occurrence frequencies for imputation	true
Parametric uncertainty	false
Filter samples exceeding the concentration limits	false	Retrospective dietary CRA (EC 2018) - Acute / Tier I	Concentrations
Use substance conversion rules	true	Retrospective dietary CRA (EC 2018) - Acute / Tier I	Concentrations
Substance conversion method	UseMostToxic	Retrospective dietary CRA (EC 2018) - Acute / Tier I	Concentrations
Retain all allocated substances after active substance allocation	true	Retrospective dietary CRA (EC 2018) - Acute / Tier I	Concentrations
Account for substance authorisations in substance conversions	false	Retrospective dietary CRA (EC 2018) - Acute / Tier I	Concentrations
Fix duplicate substance allocation inconsistencies	false	Retrospective dietary CRA (EC 2018) - Acute / Tier I	Concentrations
Use extrapolation rules	true	Retrospective dietary CRA (EC 2018) - Acute / Tier I	Concentrations
Threshold for extrapolation	10	Retrospective dietary CRA (EC 2018) - Acute / Tier I	Concentrations
Restrict extrapolations to equal MRLs	true	Retrospective dietary CRA (EC 2018) - Acute / Tier I	Concentrations
Restrict extrapolations to authorised uses	true	Retrospective dietary CRA (EC 2018) - Acute / Tier I	Concentrations
Impute water concentrations	true	Retrospective dietary CRA (EC 2018) - Acute / Tier I	Concentrations
Water concentration value (µg/kg)	0.1	Retrospective dietary CRA (EC 2018) - Acute / Tier I	Concentrations
Restrict water imputation to the five most toxic substances	true	Retrospective dietary CRA (EC 2018) - Acute / Tier I	Concentrations
Restrict water imputation to authorised uses	false	Retrospective dietary CRA (EC 2018) - Acute / Tier I	Concentrations
Restrict water imputation to approved substances	false	Retrospective dietary CRA (EC 2018) - Acute / Tier I	Concentrations
Apply occurrence pattern percentages	false	Retrospective dietary CRA (EC 2018) - Acute / Tier I	Occurrence patterns

Retrospective dietary CRA (EC 2018) - Chronic / Tier I

Table 55 Tier definition for Retrospective dietary CRA (EC 2018) - Chronic / Tier I.
Name	Setting	From input tier	In module
Default concentration model	Empirical
Include MRL fallback model	false
Restrict LOR imputation to authorised uses	false
Censored values replacement	ReplaceByLOR
Factor f (f x LOR or f x LOD or LOD + f x (LOQ - LOD)	0.5
Sample based	true
Impute missing values from available values (if unchecked, missing values are imputed with 0)	true
Correlate imputed values with sample potency	true
Use occurrence frequencies for imputation	true
Parametric uncertainty	false
Filter samples exceeding the concentration limits	false	Retrospective dietary CRA (EC 2018) - Chronic / Tier I	Concentrations
Use substance conversion rules	true	Retrospective dietary CRA (EC 2018) - Chronic / Tier I	Concentrations
Substance conversion method	UseMostToxic	Retrospective dietary CRA (EC 2018) - Chronic / Tier I	Concentrations
Retain all allocated substances after active substance allocation	true	Retrospective dietary CRA (EC 2018) - Chronic / Tier I	Concentrations
Account for substance authorisations in substance conversions	false	Retrospective dietary CRA (EC 2018) - Chronic / Tier I	Concentrations
Fix duplicate substance allocation inconsistencies	false	Retrospective dietary CRA (EC 2018) - Chronic / Tier I	Concentrations
Use extrapolation rules	true	Retrospective dietary CRA (EC 2018) - Chronic / Tier I	Concentrations
Threshold for extrapolation	10	Retrospective dietary CRA (EC 2018) - Chronic / Tier I	Concentrations
Restrict extrapolations to equal MRLs	true	Retrospective dietary CRA (EC 2018) - Chronic / Tier I	Concentrations
Restrict extrapolations to authorised uses	true	Retrospective dietary CRA (EC 2018) - Chronic / Tier I	Concentrations
Impute water concentrations	true	Retrospective dietary CRA (EC 2018) - Chronic / Tier I	Concentrations
Water concentration value (µg/kg)	0.1	Retrospective dietary CRA (EC 2018) - Chronic / Tier I	Concentrations
Restrict water imputation to the five most toxic substances	true	Retrospective dietary CRA (EC 2018) - Chronic / Tier I	Concentrations
Restrict water imputation to authorised uses	false	Retrospective dietary CRA (EC 2018) - Chronic / Tier I	Concentrations
Restrict water imputation to approved substances	false	Retrospective dietary CRA (EC 2018) - Chronic / Tier I	Concentrations
Apply occurrence pattern percentages	false	Retrospective dietary CRA (EC 2018) - Chronic / Tier I	Occurrence patterns

Retrospective dietary CRA (EC 2018) - Acute / Tier II

Table 56 Tier definition for Retrospective dietary CRA (EC 2018) - Acute / Tier II.
Name	Setting	From input tier	In module
Default concentration model	Empirical
Include MRL fallback model	false
Restrict LOR imputation to authorised uses	false
Censored values replacement	ReplaceByLOR
Factor f (f x LOR or f x LOD or LOD + f x (LOQ - LOD)	0.5
Sample based	true
Impute missing values from available values (if unchecked, missing values are imputed with 0)	true
Correlate imputed values with sample potency	false
Use occurrence frequencies for imputation	true
Parametric uncertainty	false
Filter samples exceeding the concentration limits	false	Retrospective dietary CRA (EC 2018) - Acute / Tier II	Concentrations
Use substance conversion rules	true	Retrospective dietary CRA (EC 2018) - Acute / Tier II	Concentrations
Substance conversion method	DrawRandom	Retrospective dietary CRA (EC 2018) - Acute / Tier II	Concentrations
Retain all allocated substances after active substance allocation	true	Retrospective dietary CRA (EC 2018) - Acute / Tier II	Concentrations
Account for substance authorisations in substance conversions	true	Retrospective dietary CRA (EC 2018) - Acute / Tier II	Concentrations
Fix duplicate substance allocation inconsistencies	false	Retrospective dietary CRA (EC 2018) - Acute / Tier II	Concentrations
Use extrapolation rules	true	Retrospective dietary CRA (EC 2018) - Acute / Tier II	Concentrations
Threshold for extrapolation	10	Retrospective dietary CRA (EC 2018) - Acute / Tier II	Concentrations
Restrict extrapolations to equal MRLs	true	Retrospective dietary CRA (EC 2018) - Acute / Tier II	Concentrations
Restrict extrapolations to authorised uses	true	Retrospective dietary CRA (EC 2018) - Acute / Tier II	Concentrations
Impute water concentrations	true	Retrospective dietary CRA (EC 2018) - Acute / Tier II	Concentrations
Water concentration value (µg/kg)	0.05	Retrospective dietary CRA (EC 2018) - Acute / Tier II	Concentrations
Restrict water imputation to the five most toxic substances	true	Retrospective dietary CRA (EC 2018) - Acute / Tier II	Concentrations
Restrict water imputation to authorised uses	false	Retrospective dietary CRA (EC 2018) - Acute / Tier II	Concentrations
Restrict water imputation to approved substances	false	Retrospective dietary CRA (EC 2018) - Acute / Tier II	Concentrations
Apply occurrence pattern percentages	true	Retrospective dietary CRA (EC 2018) - Acute / Tier II	Occurrence patterns
Scale up use frequency to 100%	true	Retrospective dietary CRA (EC 2018) - Acute / Tier II	Occurrence patterns
Restrict use percentage up-scaling to authorised uses	true	Retrospective dietary CRA (EC 2018) - Acute / Tier II	Occurrence patterns

Retrospective dietary CRA (EC 2018) - Chronic / Tier II

Table 57 Tier definition for Retrospective dietary CRA (EC 2018) - Chronic / Tier II.
Name	Setting	From input tier	In module
Default concentration model	Empirical
Include MRL fallback model	false
Restrict LOR imputation to authorised uses	false
Censored values replacement	ReplaceByLOR
Factor f (f x LOR or f x LOD or LOD + f x (LOQ - LOD)	0.5
Sample based	true
Impute missing values from available values (if unchecked, missing values are imputed with 0)	true
Correlate imputed values with sample potency	false
Use occurrence frequencies for imputation	true
Parametric uncertainty	false
Filter samples exceeding the concentration limits	false	Retrospective dietary CRA (EC 2018) - Chronic / Tier II	Concentrations
Use substance conversion rules	true	Retrospective dietary CRA (EC 2018) - Chronic / Tier II	Concentrations
Substance conversion method	DrawRandom	Retrospective dietary CRA (EC 2018) - Chronic / Tier II	Concentrations
Retain all allocated substances after active substance allocation	true	Retrospective dietary CRA (EC 2018) - Chronic / Tier II	Concentrations
Account for substance authorisations in substance conversions	true	Retrospective dietary CRA (EC 2018) - Chronic / Tier II	Concentrations
Fix duplicate substance allocation inconsistencies	false	Retrospective dietary CRA (EC 2018) - Chronic / Tier II	Concentrations
Use extrapolation rules	true	Retrospective dietary CRA (EC 2018) - Chronic / Tier II	Concentrations
Threshold for extrapolation	10	Retrospective dietary CRA (EC 2018) - Chronic / Tier II	Concentrations
Restrict extrapolations to equal MRLs	true	Retrospective dietary CRA (EC 2018) - Chronic / Tier II	Concentrations
Restrict extrapolations to authorised uses	true	Retrospective dietary CRA (EC 2018) - Chronic / Tier II	Concentrations
Impute water concentrations	true	Retrospective dietary CRA (EC 2018) - Chronic / Tier II	Concentrations
Water concentration value (µg/kg)	0.05	Retrospective dietary CRA (EC 2018) - Chronic / Tier II	Concentrations
Restrict water imputation to the five most toxic substances	true	Retrospective dietary CRA (EC 2018) - Chronic / Tier II	Concentrations
Restrict water imputation to authorised uses	false	Retrospective dietary CRA (EC 2018) - Chronic / Tier II	Concentrations
Restrict water imputation to approved substances	false	Retrospective dietary CRA (EC 2018) - Chronic / Tier II	Concentrations
Apply occurrence pattern percentages	true	Retrospective dietary CRA (EC 2018) - Chronic / Tier II	Occurrence patterns
Scale up use frequency to 100%	true	Retrospective dietary CRA (EC 2018) - Chronic / Tier II	Occurrence patterns
Restrict use percentage up-scaling to authorised uses	true	Retrospective dietary CRA (EC 2018) - Chronic / Tier II	Occurrence patterns

Retrospective dietary CRA (EFSA 2012) - Optimistic

Use the optimistic model settings according to the EFSA Guidance 2012. Concentration values are sampled using a sample-based empirical distribution. Available processing factors are applied. No unit variability model should be applied.

Table 58 Tier definition for Retrospective dietary CRA (EFSA 2012) - Optimistic.
Name	Setting
Default concentration model	Empirical
Include MRL fallback model	false
Censored values replacement	ReplaceByZero
Sample based	true
Impute missing values from available values (if unchecked, missing values are imputed with 0)	false
Correlate imputed values with sample potency	false
Use occurrence frequencies for imputation	false
Parametric uncertainty	false

Retrospective dietary CRA (EFSA 2012) - Acute / Pessimistic

Acute probabilistic exposure assessment using the pessimistic model settings according to the EFSA Guidance 2012. Only processing factors > 1 are applied. For unit variability, the Beta distribution is applied.

Table 59 Tier definition for Retrospective dietary CRA (EFSA 2012) - Acute / Pessimistic.
Name	Setting	From input tier	In module
Default concentration model	NonDetectSpikeLogNormal
Include MRL fallback model	true
Restrict LOR imputation to authorised uses	false
Censored values replacement	ReplaceByLOR
Factor f (f x LOR or f x LOD or LOD + f x (LOQ - LOD)	1
MRL Factor (f x MRL)	1
Sample based	true
Impute missing values from available values (if unchecked, missing values are imputed with 0)	true
Correlate imputed values with sample potency	true
Parametric uncertainty	true
Filter samples exceeding the concentration limits	false	Retrospective dietary CRA (EFSA 2012) - Acute / Pessimistic	Concentrations

Retrospective dietary CRA (EFSA 2012) - Chronic / Pessimistic

Chronic probabilistic exposure assessment using the pessimistic model settings according to the EFSA Guidance 2012. Only processing factors > 1 are applied.

Table 60 Tier definition for Retrospective dietary CRA (EFSA 2012) - Chronic / Pessimistic.
Name	Setting	From input tier	In module
Default concentration model	NonDetectSpikeLogNormal
Include MRL fallback model	true
Restrict LOR imputation to authorised uses	false
Censored values replacement	ReplaceByLOR
Factor f (f x LOR or f x LOD or LOD + f x (LOQ - LOD)	1
MRL Factor (f x MRL)	1
Sample based	true
Impute missing values from available values (if unchecked, missing values are imputed with 0)	true
Correlate imputed values with sample potency	true
Parametric uncertainty	false
Filter samples exceeding the concentration limits	false	Retrospective dietary CRA (EFSA 2012) - Chronic / Pessimistic	Concentrations

Retrospective dietary CRA (EFSA 2022) - Acute / Tier I

Table 61 Tier definition for Retrospective dietary CRA (EFSA 2022) - Acute / Tier I.
Name	Setting	From input tier	In module
Default concentration model	Empirical
Include MRL fallback model	false
Restrict LOR imputation to authorised uses	false
Censored values replacement	ReplaceByLOR
Factor f (f x LOR or f x LOD or LOD + f x (LOQ - LOD)	0.5
Sample based	true
Impute missing values from available values (if unchecked, missing values are imputed with 0)	true
Correlate imputed values with sample potency	true
Use occurrence frequencies for imputation	true
Parametric uncertainty	false
Filter samples exceeding the concentration limits	false	Retrospective dietary CRA (EFSA 2022) - Acute / Tier I	Concentrations
Use substance conversion rules	true	Retrospective dietary CRA (EFSA 2022) - Acute / Tier I	Concentrations
Substance conversion method	UseMostToxic	Retrospective dietary CRA (EFSA 2022) - Acute / Tier I	Concentrations
Retain all allocated substances after active substance allocation	true	Retrospective dietary CRA (EFSA 2022) - Acute / Tier I	Concentrations
Account for substance authorisations in substance conversions	false	Retrospective dietary CRA (EFSA 2022) - Acute / Tier I	Concentrations
Fix duplicate substance allocation inconsistencies	false	Retrospective dietary CRA (EFSA 2022) - Acute / Tier I	Concentrations
Use extrapolation rules	false	Retrospective dietary CRA (EFSA 2022) - Acute / Tier I	Concentrations
Impute water concentrations	true	Retrospective dietary CRA (EFSA 2022) - Acute / Tier I	Concentrations
Water concentration value (µg/kg)	0.1	Retrospective dietary CRA (EFSA 2022) - Acute / Tier I	Concentrations
Restrict water imputation to the five most toxic substances	true	Retrospective dietary CRA (EFSA 2022) - Acute / Tier I	Concentrations
Restrict water imputation to authorised uses	false	Retrospective dietary CRA (EFSA 2022) - Acute / Tier I	Concentrations
Restrict water imputation to approved substances	true	Retrospective dietary CRA (EFSA 2022) - Acute / Tier I	Concentrations
Apply occurrence pattern percentages	false	Retrospective dietary CRA (EFSA 2022) - Acute / Tier I	Occurrence patterns

Retrospective dietary CRA (EFSA 2022) - Chronic / Tier I

Table 62 Tier definition for Retrospective dietary CRA (EFSA 2022) - Chronic / Tier I.
Name	Setting	From input tier	In module
Default concentration model	Empirical
Include MRL fallback model	false
Restrict LOR imputation to authorised uses	false
Censored values replacement	ReplaceByLOR
Factor f (f x LOR or f x LOD or LOD + f x (LOQ - LOD)	0.5
Sample based	true
Impute missing values from available values (if unchecked, missing values are imputed with 0)	true
Correlate imputed values with sample potency	true
Use occurrence frequencies for imputation	true
Parametric uncertainty	false
Filter samples exceeding the concentration limits	false	Retrospective dietary CRA (EFSA 2022) - Chronic / Tier I	Concentrations
Use substance conversion rules	true	Retrospective dietary CRA (EFSA 2022) - Chronic / Tier I	Concentrations
Substance conversion method	UseMostToxic	Retrospective dietary CRA (EFSA 2022) - Chronic / Tier I	Concentrations
Retain all allocated substances after active substance allocation	true	Retrospective dietary CRA (EFSA 2022) - Chronic / Tier I	Concentrations
Account for substance authorisations in substance conversions	false	Retrospective dietary CRA (EFSA 2022) - Chronic / Tier I	Concentrations
Fix duplicate substance allocation inconsistencies	false	Retrospective dietary CRA (EFSA 2022) - Chronic / Tier I	Concentrations
Use extrapolation rules	false	Retrospective dietary CRA (EFSA 2022) - Chronic / Tier I	Concentrations
Impute water concentrations	true	Retrospective dietary CRA (EFSA 2022) - Chronic / Tier I	Concentrations
Water concentration value (µg/kg)	0.1	Retrospective dietary CRA (EFSA 2022) - Chronic / Tier I	Concentrations
Restrict water imputation to the five most toxic substances	true	Retrospective dietary CRA (EFSA 2022) - Chronic / Tier I	Concentrations
Restrict water imputation to authorised uses	false	Retrospective dietary CRA (EFSA 2022) - Chronic / Tier I	Concentrations
Restrict water imputation to approved substances	true	Retrospective dietary CRA (EFSA 2022) - Chronic / Tier I	Concentrations
Apply occurrence pattern percentages	false	Retrospective dietary CRA (EFSA 2022) - Chronic / Tier I	Occurrence patterns

Retrospective dietary CRA (EFSA 2022) - Acute / Tier II

Table 63 Tier definition for Retrospective dietary CRA (EFSA 2022) - Acute / Tier II.
Name	Setting	From input tier	In module
Default concentration model	Empirical
Include MRL fallback model	false
Restrict LOR imputation to authorised uses	false
Censored values replacement	ReplaceByLOR
Factor f (f x LOR or f x LOD or LOD + f x (LOQ - LOD)	0.5
Sample based	true
Impute missing values from available values (if unchecked, missing values are imputed with 0)	true
Correlate imputed values with sample potency	false
Use occurrence frequencies for imputation	true
Parametric uncertainty	false
Filter samples exceeding the concentration limits	false	Retrospective dietary CRA (EFSA 2022) - Acute / Tier II	Concentrations
Use substance conversion rules	true	Retrospective dietary CRA (EFSA 2022) - Acute / Tier II	Concentrations
Substance conversion method	DrawRandom	Retrospective dietary CRA (EFSA 2022) - Acute / Tier II	Concentrations
Retain all allocated substances after active substance allocation	true	Retrospective dietary CRA (EFSA 2022) - Acute / Tier II	Concentrations
Account for substance authorisations in substance conversions	true	Retrospective dietary CRA (EFSA 2022) - Acute / Tier II	Concentrations
Fix duplicate substance allocation inconsistencies	false	Retrospective dietary CRA (EFSA 2022) - Acute / Tier II	Concentrations
Use extrapolation rules	false	Retrospective dietary CRA (EFSA 2022) - Acute / Tier II	Concentrations
Impute water concentrations	true	Retrospective dietary CRA (EFSA 2022) - Acute / Tier II	Concentrations
Water concentration value (µg/kg)	0.05	Retrospective dietary CRA (EFSA 2022) - Acute / Tier II	Concentrations
Restrict water imputation to the five most toxic substances	true	Retrospective dietary CRA (EFSA 2022) - Acute / Tier II	Concentrations
Restrict water imputation to authorised uses	false	Retrospective dietary CRA (EFSA 2022) - Acute / Tier II	Concentrations
Restrict water imputation to approved substances	true	Retrospective dietary CRA (EFSA 2022) - Acute / Tier II	Concentrations
Apply occurrence pattern percentages	true	Retrospective dietary CRA (EFSA 2022) - Acute / Tier II	Occurrence patterns
Scale up use frequency to 100%	true	Retrospective dietary CRA (EFSA 2022) - Acute / Tier II	Occurrence patterns
Restrict use percentage up-scaling to authorised uses	true	Retrospective dietary CRA (EFSA 2022) - Acute / Tier II	Occurrence patterns

Retrospective dietary CRA (EFSA 2022) - Chronic / Tier II

Table 64 Tier definition for Retrospective dietary CRA (EFSA 2022) - Chronic / Tier II.
Name	Setting	From input tier	In module
Default concentration model	Empirical
Include MRL fallback model	false
Restrict LOR imputation to authorised uses	false
Censored values replacement	ReplaceByLOR
Factor f (f x LOR or f x LOD or LOD + f x (LOQ - LOD)	0.5
Sample based	true
Impute missing values from available values (if unchecked, missing values are imputed with 0)	true
Correlate imputed values with sample potency	false
Use occurrence frequencies for imputation	true
Parametric uncertainty	false
Filter samples exceeding the concentration limits	false	Retrospective dietary CRA (EFSA 2022) - Chronic / Tier II	Concentrations
Use substance conversion rules	true	Retrospective dietary CRA (EFSA 2022) - Chronic / Tier II	Concentrations
Substance conversion method	DrawRandom	Retrospective dietary CRA (EFSA 2022) - Chronic / Tier II	Concentrations
Retain all allocated substances after active substance allocation	true	Retrospective dietary CRA (EFSA 2022) - Chronic / Tier II	Concentrations
Account for substance authorisations in substance conversions	true	Retrospective dietary CRA (EFSA 2022) - Chronic / Tier II	Concentrations
Fix duplicate substance allocation inconsistencies	false	Retrospective dietary CRA (EFSA 2022) - Chronic / Tier II	Concentrations
Use extrapolation rules	false	Retrospective dietary CRA (EFSA 2022) - Chronic / Tier II	Concentrations
Impute water concentrations	true	Retrospective dietary CRA (EFSA 2022) - Chronic / Tier II	Concentrations
Water concentration value (µg/kg)	0.05	Retrospective dietary CRA (EFSA 2022) - Chronic / Tier II	Concentrations
Restrict water imputation to the five most toxic substances	true	Retrospective dietary CRA (EFSA 2022) - Chronic / Tier II	Concentrations
Restrict water imputation to authorised uses	false	Retrospective dietary CRA (EFSA 2022) - Chronic / Tier II	Concentrations
Restrict water imputation to approved substances	true	Retrospective dietary CRA (EFSA 2022) - Chronic / Tier II	Concentrations
Apply occurrence pattern percentages	true	Retrospective dietary CRA (EFSA 2022) - Chronic / Tier II	Occurrence patterns
Scale up use frequency to 100%	true	Retrospective dietary CRA (EFSA 2022) - Chronic / Tier II	Occurrence patterns
Restrict use percentage up-scaling to authorised uses	true	Retrospective dietary CRA (EFSA 2022) - Chronic / Tier II	Occurrence patterns

Prospective dietary CRA (EFSA 2023) - Acute / Tier II

Table 65 Tier definition for Prospective dietary CRA (EFSA 2023) - Acute / Tier II.
Name	Setting	From input tier	In module
Default concentration model	Empirical
Include MRL fallback model	false
Restrict LOR imputation to authorised uses	false
Censored values replacement	ReplaceByLOR
Factor f (f x LOR or f x LOD or LOD + f x (LOQ - LOD)	0.5
Sample based	true
Impute missing values from available values (if unchecked, missing values are imputed with 0)	true
Correlate imputed values with sample potency	false
Use occurrence frequencies for imputation	true
Parametric uncertainty	false
Filter samples exceeding the concentration limits	true	Prospective dietary CRA (EFSA 2023) - Acute / Tier II	Concentrations
Concentration limit filter exceedance factor	2	Prospective dietary CRA (EFSA 2023) - Acute / Tier II	Concentrations
Use substance conversion rules	true	Prospective dietary CRA (EFSA 2023) - Acute / Tier II	Concentrations
Substance conversion method	DrawRandom	Prospective dietary CRA (EFSA 2023) - Acute / Tier II	Concentrations
Retain all allocated substances after active substance allocation	true	Prospective dietary CRA (EFSA 2023) - Acute / Tier II	Concentrations
Account for substance authorisations in substance conversions	true	Prospective dietary CRA (EFSA 2023) - Acute / Tier II	Concentrations
Fix duplicate substance allocation inconsistencies	false	Prospective dietary CRA (EFSA 2023) - Acute / Tier II	Concentrations
Use extrapolation rules	false	Prospective dietary CRA (EFSA 2023) - Acute / Tier II	Concentrations
Impute water concentrations	true	Prospective dietary CRA (EFSA 2023) - Acute / Tier II	Concentrations
Water concentration value (µg/kg)	0.05	Prospective dietary CRA (EFSA 2023) - Acute / Tier II	Concentrations
Restrict water imputation to the five most toxic substances	true	Prospective dietary CRA (EFSA 2023) - Acute / Tier II	Concentrations
Restrict water imputation to authorised uses	false	Prospective dietary CRA (EFSA 2023) - Acute / Tier II	Concentrations
Restrict water imputation to approved substances	true	Prospective dietary CRA (EFSA 2023) - Acute / Tier II	Concentrations
Include focal commodity concentrations	true	Prospective dietary CRA (EFSA 2023) - Acute / Tier II	Concentrations
Focal commodity concentrations replacement method	ReplaceSubstances	Prospective dietary CRA (EFSA 2023) - Acute / Tier II	Concentrations
Focal commodity substance occurrence percentage	20	Prospective dietary CRA (EFSA 2023) - Acute / Tier II	Concentrations
Adjustment factor for the focal food/substance concentration	1	Prospective dietary CRA (EFSA 2023) - Acute / Tier II	Concentrations
Use deterministic substance conversions for focal commodity	true	Prospective dietary CRA (EFSA 2023) - Acute / Tier II	Concentrations
Apply occurrence pattern percentages	true	Prospective dietary CRA (EFSA 2023) - Acute / Tier II	Occurrence patterns
Scale up use frequency to 100%	true	Prospective dietary CRA (EFSA 2023) - Acute / Tier II	Occurrence patterns
Restrict use percentage up-scaling to authorised uses	true	Prospective dietary CRA (EFSA 2023) - Acute / Tier II	Occurrence patterns

Prospective dietary CRA (EFSA 2023) - Chronic / Tier II

Table 66 Tier definition for Prospective dietary CRA (EFSA 2023) - Chronic / Tier II.
Name	Setting	From input tier	In module
Default concentration model	Empirical
Include MRL fallback model	false
Restrict LOR imputation to authorised uses	false
Censored values replacement	ReplaceByLOR
Factor f (f x LOR or f x LOD or LOD + f x (LOQ - LOD)	0.5
Sample based	true
Impute missing values from available values (if unchecked, missing values are imputed with 0)	true
Correlate imputed values with sample potency	false
Use occurrence frequencies for imputation	true
Parametric uncertainty	false
Filter samples exceeding the concentration limits	true	Prospective dietary CRA (EFSA 2023) - Chronic / Tier II	Concentrations
Concentration limit filter exceedance factor	2	Prospective dietary CRA (EFSA 2023) - Chronic / Tier II	Concentrations
Use substance conversion rules	true	Prospective dietary CRA (EFSA 2023) - Chronic / Tier II	Concentrations
Substance conversion method	DrawRandom	Prospective dietary CRA (EFSA 2023) - Chronic / Tier II	Concentrations
Retain all allocated substances after active substance allocation	true	Prospective dietary CRA (EFSA 2023) - Chronic / Tier II	Concentrations
Account for substance authorisations in substance conversions	true	Prospective dietary CRA (EFSA 2023) - Chronic / Tier II	Concentrations
Fix duplicate substance allocation inconsistencies	false	Prospective dietary CRA (EFSA 2023) - Chronic / Tier II	Concentrations
Use extrapolation rules	false	Prospective dietary CRA (EFSA 2023) - Chronic / Tier II	Concentrations
Impute water concentrations	true	Prospective dietary CRA (EFSA 2023) - Chronic / Tier II	Concentrations
Water concentration value (µg/kg)	0.05	Prospective dietary CRA (EFSA 2023) - Chronic / Tier II	Concentrations
Restrict water imputation to the five most toxic substances	true	Prospective dietary CRA (EFSA 2023) - Chronic / Tier II	Concentrations
Restrict water imputation to authorised uses	false	Prospective dietary CRA (EFSA 2023) - Chronic / Tier II	Concentrations
Restrict water imputation to approved substances	true	Prospective dietary CRA (EFSA 2023) - Chronic / Tier II	Concentrations
Include focal commodity concentrations	true	Prospective dietary CRA (EFSA 2023) - Chronic / Tier II	Concentrations
Focal commodity concentrations replacement method	ReplaceSubstances	Prospective dietary CRA (EFSA 2023) - Chronic / Tier II	Concentrations
Focal commodity substance occurrence percentage	20	Prospective dietary CRA (EFSA 2023) - Chronic / Tier II	Concentrations
Adjustment factor for the focal food/substance concentration	1	Prospective dietary CRA (EFSA 2023) - Chronic / Tier II	Concentrations
Use deterministic substance conversions for focal commodity	true	Prospective dietary CRA (EFSA 2023) - Chronic / Tier II	Concentrations
Apply occurrence pattern percentages	true	Prospective dietary CRA (EFSA 2023) - Chronic / Tier II	Occurrence patterns
Scale up use frequency to 100%	true	Prospective dietary CRA (EFSA 2023) - Chronic / Tier II	Occurrence patterns
Restrict use percentage up-scaling to authorised uses	true	Prospective dietary CRA (EFSA 2023) - Chronic / Tier II	Occurrence patterns