Concentrations tiers

In addition to the possibility for users to work with their own choices for all settings, MCRA implements Tier 1 and 2 from the European Commission working document SANTE-2015-10216 rev. 7 (2018) on risk management aspects related to the assessment of cumulative exposure.

Overview

Table 64 Tier overview for module Concentrations.
Name EC 2018 Tier 1 EC 2018 Tier 2

Substance conversion method

UseMostToxic

DrawRandom

Retain all allocated substances after active substance allocation

true

true

Account for substance authorisations in substance conversions

false

true

Fix duplicate substance allocation inconsistencies

false

false

Use extrapolation rules

true

true

Threshold for extrapolation

10

10

Restrict extrapolations to equal MRLs

true

true

Restrict extrapolations to authorised uses

true

true

Impute water concentrations

true

true

Water concentration value (µg/kg)

0.1

0.05

Restrict water imputation to the five most toxic substances

true

true

Restrict water imputation to authorised uses

false

false

Restrict water imputation to approved substances

false

false

EC 2018 Tier 1

Table 65 Tier definition for EC 2018 Tier 1.
Name Setting

Substance conversion method

UseMostToxic

Retain all allocated substances after active substance allocation

true

Account for substance authorisations in substance conversions

false

Fix duplicate substance allocation inconsistencies

false

Use extrapolation rules

true

Threshold for extrapolation

10

Restrict extrapolations to equal MRLs

true

Restrict extrapolations to authorised uses

true

Impute water concentrations

true

Water concentration value (µg/kg)

0.1

Restrict water imputation to the five most toxic substances

true

Restrict water imputation to authorised uses

false

Restrict water imputation to approved substances

false

EC 2018 Tier 2

Table 66 Tier definition for EC 2018 Tier 2.
Name Setting

Substance conversion method

DrawRandom

Retain all allocated substances after active substance allocation

true

Account for substance authorisations in substance conversions

true

Fix duplicate substance allocation inconsistencies

false

Use extrapolation rules

true

Threshold for extrapolation

10

Restrict extrapolations to equal MRLs

true

Restrict extrapolations to authorised uses

true

Impute water concentrations

true

Water concentration value (µg/kg)

0.05

Restrict water imputation to the five most toxic substances

true

Restrict water imputation to authorised uses

false

Restrict water imputation to approved substances

false