Hazard modules

Hazard data exist at two levels: at a lower level dose response data give responses measured in test systems from doses of active substances. Such data can be modelled with dose response models.

At a higher level responses can be linked to effects, optionally via AOP networks, using effect representations. If benchmark responses (BMRs) have been specified, dose response models can calculate Benchmark Doses (BMDs), which are the preferred Points of departure in hazard assessments. In addition, or alternatively, external points of departure can be specified for active substances and effects.

BMDs from dose response models and/or other points of departure can be converted to hazard characterisations at the intended level (external or internal dose, without or with safety factors), using kinetic models, inter-species conversions and/or intra-species factors. Finally, hazard characterisations can be translated to relative potency factors.

• Active substances
• AOP networks
• Dose response data
• Dose response models
• Effect representations
• Hazard characterisations
• Inter-species conversions
• Intra species factors
• Points of departure
• Relative potency factors