Risk steatosis from imazalil¶
This standard action is of type: Risks
In-vitro tests may help to reduce the use of test animals. What is the impact of this for risk assess-ment? Traditional risk assessment often uses animal data to evaluate toxicological limit values, such as the acceptable daily intake (ADI). In this standard action such a traditional risk calculation for the example of steatosis as health effect and imazalil as chemical substance can be compared to a simi-lar calculation, but with the toxicological hazard characterisation based on in-vitro data from Adi-poRed measurements in human liver cells. In-vitro concentrations are assumed to represent inter-nal liver concentrations and a human physiologically based kinetic model for imazalil is used to ex-trapolate from in vitro to in vivo doses.
| Table Group | Name | Repository | Type |
|---|---|---|---|
AdverseOutcomePathwayNetworks |
AOPN-Effects-EffectRelations-181017.xlsx |
Standard Actions/Risk steatosis from imazalil |
Fixed |
Effects |
AOPN-Effects-EffectRelations-181017.xlsx |
Standard Actions/Risk steatosis from imazalil |
Fixed |
DoseResponseData |
BfR-HepaRG-AdipoRed-Single.xlsx |
Standard Actions/Risk steatosis from imazalil |
Fixed |
Concentrations |
ConcentrationsSSD_20190129.zip |
Standard Actions/Risk steatosis from imazalil |
Fixed |
Survey |
ConsumptionsNL YoungAdults&Kids.mdb |
Standard Actions/Risk steatosis from imazalil |
Fixed |
Compounds |
EuroMix Substances Inventory (v8) (PPPs).zip |
Standard Actions/Risk steatosis from imazalil |
Fixed |
KineticModels |
EuroMix-KineticModels-CosmosV6 9 substances_QSAR_vitro.xlsx |
Standard Actions/Risk steatosis from imazalil |
Fixed |
Foods |
Foods coded in FoodEx1.mdb |
Standard Actions/Risk steatosis from imazalil |
Fixed |
UnitVariability |
Foods coded in FoodEx1.mdb |
Standard Actions/Risk steatosis from imazalil |
Fixed |
FoodTranslations |
Foods translations coded in FoodEx1.mdb |
Standard Actions/Risk steatosis from imazalil |
Fixed |
HazardCharacterisations |
HazardCharacterisation Imazalil.xlsx |
Standard Actions/Risk steatosis from imazalil |
Fixed |
EffectRepresentations |
TestSystems-Responses-EffectRepresentations-181026.xlsx |
Standard Actions/Risk steatosis from imazalil |
Fixed |
Responses |
TestSystems-Responses-EffectRepresentations-181026.xlsx |
Standard Actions/Risk steatosis from imazalil |
Fixed |
TestSystems |
TestSystems-Responses-EffectRepresentations-181026.xlsx |
Standard Actions/Risk steatosis from imazalil |
Fixed |